Search Results - "DEVIN M. SWANSON" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist

Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist

by Swanson, Devin M, Dubin, Adrienne E, Shah, Chandra, Nasser, Nadia, Chang, Leon, Dax, Scott L, Jetter, Michele, Breitenbucher, J. Guy, Liu, Changlu, Mazur, Curt, Lord, Brian, Gonzales, Lisa, Hoey, Kenway, Rizzolio, Michele, Bogenstaetter, Michael, Codd, Ellen E, Lee, Doo H, Zhang, Sui-Po, Chaplan, Sandra R, Carruthers, Nicholas I
Published in Journal of medicinal chemistry (24.03.2005)

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Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs

Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs

by Bhattacharya, Anindya, Scott, Brian P, Nasser, Nadia, Ao, Hong, Maher, Michael P, Dubin, Adrienne E, Swanson, Devin M, Shankley, Nigel P, Wickenden, Alan D, Chaplan, Sandra R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)

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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

by Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)

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Aplysamine-1 and related analogs as histamine H3 receptor antagonists

Aplysamine-1 and related analogs as histamine H3 receptor antagonists

by SWANSON, Devin M, WILSON, Sandy J, BOGGS, Jamin D, WEI XIAO, APODACA, Richard, BARBIER, Ann J, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I
Published in Bioorganic & medicinal chemistry letters (15.02.2006)

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Identification of (R)‑(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro‑1H‑imidazo[4,5‑c]pyridin-5(4H)‑yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

Identification of (R)‑(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro‑1H‑imidazo[4,5‑c]pyridin-5(4H)‑yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

by Swanson, Devin M, Savall, Brad M, Coe, Kevin J, Schoetens, Freddy, Koudriakova, Tatiana, Skaptason, Judith, Wall, Jessica, Rech, Jason, Deng, Xiahou, De Angelis, Meri, Everson, Anita, Lord, Brian, Wang, Qi, Ao, Hong, Scott, Brian, Sepassi, Kia, Lovenberg, Timothy W, Carruthers, Nicholas I, Bhattacharya, Anindya, Letavic, Michael A
Published in Journal of medicinal chemistry (22.09.2016)

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Discovery of Imidazo[1,2‑a]pyrazines and Pyrazolo[1,5‑c]pyrimidines as TARP γ‑8 Selective AMPAR Negative Modulators

Discovery of Imidazo[1,2‑a]pyrazines and Pyrazolo[1,5‑c]pyrimidines as TARP γ‑8 Selective AMPAR Negative Modulators

by Savall, Brad M, Wu, Dongpei, Swanson, Devin M, Seierstad, Mark, Wu, Nyantsz, Vives Martinez, Jorge, García Olmos, Beatriz, Lord, Brian, Coe, Kevin, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (14.03.2019)

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Lead Optimization of 5‑Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ‑8

Lead Optimization of 5‑Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ‑8

by Ravula, Suchitra, Savall, Brad M, Wu, Nyantsz, Lord, Brian, Coe, Kevin, Wang, Kai, Seierstad, Mark, Swanson, Devin M, Ziff, Jeannie, Nguyen, Minh, Leung, Perry, Rynberg, Ray, La, David, Pippel, Daniel J, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (09.08.2018)

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In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

by Shoblock, James R., Welty, Natalie, Nepomuceno, Diane, Lord, Brian, Aluisio, Leah, Fraser, Ian, Motley, S. Timothy, Sutton, Steve W., Morton, Kirsten, Galici, Ruggero, Atack, John R., Dvorak, Lisa, Swanson, Devin M., Carruthers, Nicholas I., Dvorak, Curt, Lovenberg, Timothy W., Bonaventure, Pascal
Published in Psychopharmacology (01.02.2010)

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Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

by Letavic, Michael A, Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J, Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I, Dugovic, Christine, Fraser, Ian C, Kramer, Michelle L, Lord, Brian, Lovenberg, Timothy W, Li, Lilian Y, Ly, Kiev S, Mcallister, Heather, Mani, Neelakandha S, Morton, Kirsten L, Ndifor, Anthony, Nepomuceno, S. Diane, Pandit, Chennagiri R, Sands, Steven B, Shah, Chandra R, Shelton, Jonathan E, Snook, Sandra S, Swanson, Devin M, Xiao, Wei
Published in ACS medicinal chemistry letters (09.04.2015)

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Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists

Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists

by SWANSON, Devin M, SHAH, Chandra R, WILSON, Sandy J, BARBIER, Ann J, BONAVENTURE, Pascal, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, LORD, Brian, MORTON, Kirsten, DVORAK, Lisa K, MAZUR, Curt, APODACA, Richard, WEI XIAO, BOGGS, Jamin D, FEINSTEIN, Mark
Published in European journal of medicinal chemistry (01.11.2009)

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The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor

The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor

by Swanson, Devin M., Wong, Victoria D., Jablonowski, Jill A., Shah, Chandra, Rudolph, Dale A., Dvorak, Curt A., Seierstad, Mark, Dvorak, Lisa K., Morton, Kirsten, Nepomuceno, Diane, Atack, John R., Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)

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AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS

AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS

by CHEN GANG, FABRICE LOIC JOURDAN, CYNTHIA G B BERRY, SUCHITRA RAVULA, DEVIN M SWANSON, TERRY PATRICK LEBOLD, MICHAEL K AMERIKS, BRADLEY M SAVALL, WU DONGPEI, DAVID WEI LIN, MIGUEL ANGEL PENA PINON, ZHANG WEI
Year of Publication 18.03.2021

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Patent

4-Methyl-6,7-dihydro-4 H -triazolo[4,5- c ]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

4-Methyl-6,7-dihydro-4 H -triazolo[4,5- c ]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

by Letavic, Michael A., Savall, Brad M., Allison, Brett D., Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A., Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I., Ceusters, Marc, Coe, Kevin J., Dvorak, Curt A., Fraser, Ian C., Gelin, Christine F., Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W., Otieno, Monicah A., Schoetens, Freddy, Swanson, Devin M., Wang, Qi, Wickenden, Alan D., Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)

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Journal Article

Identification of ( R )-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1 H -imidazo[4,5- c ]pyridin-5(4 H )-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

Identification of ( R )-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1 H -imidazo[4,5- c ]pyridin-5(4 H )-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

by Swanson, Devin M., Savall, Brad M., Coe, Kevin J., Schoetens, Freddy, Koudriakova, Tatiana, Skaptason, Judith, Wall, Jessica, Rech, Jason, Deng, Xiahou, De Angelis, Meri, Everson, Anita, Lord, Brian, Wang, Qi, Ao, Hong, Scott, Brian, Sepassi, Kia, Lovenberg, Timothy W., Carruthers, Nicholas I., Bhattacharya, Anindya, Letavic, Michael A.
Published in Journal of medicinal chemistry (22.09.2016)

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Journal Article

Heterocyclic replacement of the central phenyl core of diamine-based histamine H 3 receptor antagonists

Heterocyclic replacement of the central phenyl core of diamine-based histamine H 3 receptor antagonists

by Swanson, Devin M., Shah, Chandra R., Lord, Brian, Morton, Kirsten, Dvorak, Lisa K., Mazur, Curt, Apodaca, Richard, Xiao, Wei, Boggs, Jamin D., Feinstein, Mark, Wilson, Sandy J., Barbier, Ann J., Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in European journal of medicinal chemistry (01.11.2009)

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Journal Article

The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y sub(2) receptor

The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y sub(2) receptor

by Swanson, Devin M, Wong, Victoria D, Jablonowski, Jill A, Shah, Chandra, Rudolph, Dale A, Dvorak, Curt A, Seierstad, Mark, Dvorak, Lisa K, Morton, Kirsten, Nepomuceno, Diane, Atack, John R, Bonaventure, Pascal, Lovenberg, Timothy W, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (15.09.2011)

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Journal Article

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperaz in-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y sub(2) receptor

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperaz in-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y sub(2) receptor

by Shoblock, James R, Welty, Natalie, Nepomuceno, Diane, Lord, Brian, Aluisio, Leah, Fraser, Ian, Motley, STimothy, Sutton, Steve W, Morton, Kirsten, Galici, Ruggero, Atack, John R, Dvorak, Lisa, Swanson, Devin M, Carruthers, Nicholas I, Dvorak, Curt, Lovenberg, Timothy W, Bonaventure, Pascal
Published in Psychopharmacology (01.02.2010)

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Journal Article

In vitro and in vivo characterization of JNJ-31020028 N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide, a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

In vitro and in vivo characterization of JNJ-31020028 N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide, a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

by SHOBLOCK, James R, WELTY, Natalie, ATACK, John R, DVORAK, Lisa, SWANSON, Devin M, CARRUTHERS, Nicholas I, DVORAK, Curt, LOVENBERG, Timothy W, BONAVENTURE, Pascal, NEPOMUCENO, Diane, LORD, Brian, ALUISIO, Leah, FRASER, Ian, TIMOTHY MOTLEY, S, SUTTON, Steve W, MORTON, Kirsten, GALICI, Ruggero
Published in Psychopharmacologia (2010)

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Journal Article

Aplysamine-1 and related analogs as histamine H 3 receptor antagonists

Aplysamine-1 and related analogs as histamine H 3 receptor antagonists

by Swanson, Devin M., Wilson, Sandy J., Boggs, Jamin D., Xiao, Wei, Apodaca, Richard, Barbier, Ann J., Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)

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Journal Article

Aplysamine-1 and related analogs as histamine H sub(3) receptor antagonists

Aplysamine-1 and related analogs as histamine H sub(3) receptor antagonists

by Swanson, Devin M, Wilson, Sandy J, Boggs, Jamin D, Xiao, Wei, Apodaca, Richard, Barbier, Ann J, Lovenberg, Timothy W, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (01.02.2006)

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