FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model
Deuschle, Ulrich, Schüler, Julia, Schulz, Andreas, Schlüter, Thomas, Kinzel, Olaf, Abel, Ulrich, Kremoser, Claus
Published in PloS one (09.10.2012)
Published in PloS one (09.10.2012)
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Journal Article
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice
Hambruch, Eva, Miyazaki-Anzai, Shinobu, Hahn, Ulrike, Matysik, Silke, Boettcher, Alfred, Perović-Ottstadt, Sanja, Schlüter, Thomas, Kinzel, Olaf, Krol, Helen Desiree, Deuschle, Ulrich, Burnet, Michael, Levi, Moshe, Schmitz, Gerd, Miyazaki, Makoto, Kremoser, Claus
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
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Journal Article
Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation
Takahashi, Tetsuyuki, Deuschle, Ulrich, Taira, Shu, Nishida, Takeshi, Fujimoto, Makoto, Hijikata, Takao, Tsuneyama, Koichi
Published in Hepatology international (01.05.2018)
Published in Hepatology international (01.05.2018)
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Journal Article
The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoprotein
Deuschle, Ulrich, Birkel, Manfred, Hambruch, Eva, Hornberger, Martin, Kinzel, Olaf, Perović‐Ottstadt, Sanja, Schulz, Andreas, Hahn, Ulrike, Burnet, Michael, Kremoser, Claus
Published in International journal of cancer (01.06.2015)
Published in International journal of cancer (01.06.2015)
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Journal Article
Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol
Otte, Kerstin, Kranz, Harald, Kober, Ingo, Thompson, Paul, Hoefer, Michael, Haubold, Bernhard, Remmel, Bettina, Voss, Hartmut, Kaiser, Carmen, Albers, Michael, Cheruvallath, Zaccharias, Jackson, David, Casari, Georg, Koegl, Manfred, Pääbo, Svante, Mous, Jan, Kremoser, Claus, Deuschle, Ulrich
Published in Molecular and Cellular Biology (01.02.2003)
Published in Molecular and Cellular Biology (01.02.2003)
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Journal Article
Presenilins Are Processed by Caspase-type Proteases
Loetscher, Hansruedi, Deuschle, Ulrich, Brockhaus, Manfred, Reinhardt, Dieter, Nelboeck, Peter, Mous, Jan, Grünberg, Jürgen, Haass, Christian, Jacobsen, Helmut
Published in The Journal of biological chemistry (15.08.1997)
Published in The Journal of biological chemistry (15.08.1997)
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Journal Article
A Novel Principle for Partial Agonism of Liver X Receptor Ligands
Albers, Michael, Blume, Beatrix, Schlueter, Thomas, Wright, Matthew B., Kober, Ingo, Kremoser, Claus, Deuschle, Ulrich, Koegl, Manfred
Published in The Journal of biological chemistry (24.02.2006)
Published in The Journal of biological chemistry (24.02.2006)
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Journal Article
The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction
Schwabl, Philipp, Hambruch, Eva, Seeland, Berit A, Hayden, Hubert, Wagner, Michael, Garnys, Lukas, Strobel, Bastian, Schubert, Tim-Lukas, Riedl, Florian, Mitteregger, Dieter, Burnet, Michael, Starlinger, Patrick, Oberhuber, Georg, Deuschle, Ulrich, Rohr-Udilova, Nataliya, Podesser, Bruno K, Peck-Radosavljevic, Markus, Reiberger, Thomas, Kremoser, Claus, Trauner, Michael
Published in Journal of hepatology (01.04.2017)
Published in Journal of hepatology (01.04.2017)
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Journal Article
PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study
Hambruch, Eva, Gege, Christian, Kinzel, Olaf, Hauser, Katharina, Birkel, Manfred, Deuschle, Ulrich, Kremoser, Claus
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
Development of Cilofexor, an intestinally-biased Farnesoid X Receptor agonist, for the treatment of fatty liver disease
Hollenback, David, Hambruch, Eva, Fink, Gero, Birkel, Manfred, Schulz, Andreas, Hornberger, Martin, Liu, Kathy, Staiger, Kelly MacLennan, Krol, Helen Desiree, Deuschle, Ulrich, Steeneck, Christoph, Kinzel, Olaf, Liles, John T, Budas, Grant, Watkins, William J, Kremoser, Claus
Published in The Journal of pharmacology and experimental therapeutics (26.02.2024)
Published in The Journal of pharmacology and experimental therapeutics (26.02.2024)
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Journal Article
Abstract 1210: Targeting the IDO1-Kynurenine-AhR pathway for cancer immunotherapy
Pinto, Sheena, Steeneck, Christoph, Albers, Michael, Anderhub, Simon, Birkel, Manfred, Buselic-Wölfel, Larisa, Eisenhardt, Gisela, Kremoser, Claus, Hoffmann, Thomas, Deuschle, Ulrich
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Reprogramming of the ERRα and ERα target gene landscape triggers tamoxifen resistance in breast cancer
Thewes, Verena, Simon, Ronald, Schroeter, Petra, Schlotter, Magdalena, Anzeneder, Tobias, Büttner, Reinhard, Benes, Vladimir, Sauter, Guido, Burwinkel, Barbara, Nicholson, Robert I, Sinn, Hans-Peter, Schneeweiss, Andreas, Deuschle, Ulrich, Zapatka, Marc, Heck, Stefanie, Lichter, Peter
Published in Cancer research (Chicago, Ill.) (15.02.2015)
Published in Cancer research (Chicago, Ill.) (15.02.2015)
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Journal Article
Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties
Kinzel, Olaf, Steeneck, Christoph, Schlüter, Thomas, Schulz, Andreas, Gege, Christian, Hahn, Ulrike, Hambruch, Eva, Hornberger, Martin, Spalwisz, Adriana, Frick, Katharina, Perović-Ottstadt, Sanja, Deuschle, Ulrich, Burnet, Michael, Kremoser, Claus
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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Journal Article
아민 또는 아민을 함유하는 LXR 조절제
DEUSCHLE ULRICH, KREMOSER CLAUS, GEGE CHRISTIAN, BIRKEL MANFRED, HAMBRUCH EVA
Year of Publication 09.04.2020
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Year of Publication 09.04.2020
Patent
간 X-수용체 (LXR) 조절제
DEUSCHLE ULRICH, KREMOSER CLAUS, GEGE CHRISTIAN, BIRKEL MANFRED, HAMBRUCH EVA
Year of Publication 11.12.2019
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Year of Publication 11.12.2019
Patent
Regulation of coliphage T3 and T7 RNA polymerases by the lac represser-operator system
Giordano, Thomas J., Deuschle, Ulrich, Bujard, Hermann, McAllister, William T.
Published in Gene (01.12.1989)
Published in Gene (01.12.1989)
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Journal Article
바이사이클릭 코어 모이어티를 갖는 신규한 LXR 조절제
KREMOSER CLAUS, DEUSCHLE ULRICH, GEGE CHRISTIAN, BIRKEL MANFRED, HAMBRUCH EVA, KINZEL OLAF
Year of Publication 09.03.2021
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Year of Publication 09.03.2021
Patent