In vivo demonstration that α-synuclein oligomers are toxic
Winner, Beate, Jappelli, Roberto, Maji, Samir K, Desplats, Paula A, Boyer, Leah, Aigner, Stefan, Hetzer, Claudia, Loher, Thomas, Vilar, Marçal, Campioni, Silvia, Tzitzilonis, Christos, Soragni, Alice, Jessberger, Sebastian, Mira, Helena, Consiglio, Antonella, Pham, Emiley, Masliah, Eliezer, Gage, Fred H, Riek, Roland
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2011)
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Journal Article
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
Desplats, Paula, Lee, He-Jin, Bae, Eun-Jin, Patrick, Christina, Rockenstein, Edward, Crews, Leslie, Spencer, Brian, Masliah, Eliezer, Lee, Seung-Jae
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2009)
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Journal Article
Role of α‐synuclein penetration into the membrane in the mechanisms of oligomer pore formation
Tsigelny, Igor F., Sharikov, Yuriy, Wrasidlo, Wolfgang, Gonzalez, Tania, Desplats, Paula A., Crews, Leslie, Spencer, Brian, Masliah, Eliezer
Published in The FEBS journal (01.03.2012)
Published in The FEBS journal (01.03.2012)
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Journal Article
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
Crews, Leslie, Spencer, Brian, Desplats, Paula, Patrick, Christina, Paulino, Amy, Rockenstein, Edward, Hansen, Lawrence, Adame, Anthony, Galasko, Douglas, Masliah, Eliezer
Published in PloS one (19.02.2010)
Published in PloS one (19.02.2010)
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Journal Article
Molecular and pathologic insights from latent HIV-1 infection in the human brain
Desplats, Paula, Dumaop, Wilmar, Smith, David, Adame, Anthony, Everall, Ian, Letendre, Scott, Ellis, Ronald, Cherner, Mariana, Grant, Igor, Masliah, Eliezer
Published in Neurology (09.04.2013)
Published in Neurology (09.04.2013)
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Journal Article
Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
Whittaker, Daniel S., Akhmetova, Laila, Carlin, Daniel, Romero, Haylie, Welsh, David K., Colwell, Christopher S., Desplats, Paula
Published in Cell metabolism (03.10.2023)
Published in Cell metabolism (03.10.2023)
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Journal Article
HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Thomas, Elizabeth A, Coppola, Giovanni, Desplats, Paula A, Tang, Bin, Soragni, Elisabetta, Burnett, Ryan, Gao, Fuying, Fitzgerald, Kelsey M, Borok, Jenna F, Herman, David, Geschwind, Daniel H, Gottesfeld, Joel M
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2008)
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Journal Article
Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples
Spencer, Brian, Rank, Logan, Metcalf, Jeff, Desplats, Paula
Published in Scientific reports (06.03.2018)
Published in Scientific reports (06.03.2018)
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Journal Article
Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington's Disease Patients
Gutierrez, Ashley, Corey-Bloom, Jody, Thomas, Elizabeth A, Desplats, Paula
Published in Frontiers in molecular neuroscience (23.01.2020)
Published in Frontiers in molecular neuroscience (23.01.2020)
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Journal Article
TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease
Bender, Andreas, Desplats, Paula, Spencer, Brian, Rockenstein, Edward, Adame, Anthony, Elstner, Matthias, Laub, Christoph, Mueller, Sarina, Koob, Andrew O, Mante, Michael, Pham, Emily, Klopstock, Thomas, Masliah, Eliezer
Published in PloS one (23.04.2013)
Published in PloS one (23.04.2013)
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Journal Article
Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model
Spencer, Brian, Desplats, Paula A, Overk, Cassia R, Valera-Martin, Elvira, Rissman, Robert A, Wu, Chengbiao, Mante, Michael, Adame, Anthony, Florio, Jazmin, Rockenstein, Edward, Masliah, Eliezer
Published in The Journal of neuroscience (27.07.2016)
Published in The Journal of neuroscience (27.07.2016)
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Journal Article
A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis
Spencer, Brian, Verma, Inder, Desplats, Paula, Morvinski, Dinorah, Rockenstein, Ed, Adame, Anthony, Masliah, Eliezer
Published in The Journal of biological chemistry (20.06.2014)
Published in The Journal of biological chemistry (20.06.2014)
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Journal Article
Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary
Haspel, Jeffrey A, Anafi, Ron, Brown, Marishka K, Cermakian, Nicolas, Depner, Christopher, Desplats, Paula, Gelman, Andrew E, Haack, Monika, Jelic, Sanja, Kim, Brian S, Laposky, Aaron D, Lee, Yvonne C, Mongodin, Emmanuel, Prather, Aric A, Prendergast, Brian J, Reardon, Colin, Shaw, Albert C, Sengupta, Shaon, Szentirmai, Éva, Thakkar, Mahesh, Walker, Wendy E, Solt, Laura A
Published in JCI insight (16.01.2020)
Published in JCI insight (16.01.2020)
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Journal Article
DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood
Henderson-Smith, Adrienne, Fisch, Kathleen M., Hua, Jianping, Liu, Ganqiang, Ricciardelli, Eugenia, Jepsen, Kristen, Huentelman, Mathew, Stalberg, Gabriel, Edland, Steven D., Scherzer, Clemens R., Dunckley, Travis, Desplats, Paula
Published in Epigenetics (03.04.2019)
Published in Epigenetics (03.04.2019)
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Journal Article
Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence
Desplats, Paula, Dumaop, Wilmar, Cronin, Peter, Gianella, Sara, Woods, Steven, Letendre, Scott, Smith, David, Masliah, Eliezer, Grant, Igor
Published in PloS one (23.07.2014)
Published in PloS one (23.07.2014)
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Journal Article
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
Tsigelny, Igor F, Crews, Leslie, Desplats, Paula, Shaked, Gideon M, Sharikov, Yuriy, Mizuno, Hideya, Spencer, Brian, Rockenstein, Edward, Trejo, Margarita, Platoshyn, Oleksandr, Yuan, Jason X-J, Masliah, Eliezer
Published in PloS one (04.09.2008)
Published in PloS one (04.09.2008)
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Journal Article
Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model
Winner, Beate, Desplats, Paula, Hagl, Christian, Klucken, Jochen, Aigner, Robert, Ploetz, Sonja, Laemke, Jörn, Karl, Alexandra, Aigner, Ludwig, Masliah, Eliezer, Buerger, Erich, Winkler, Jürgen
Published in Experimental neurology (01.10.2009)
Published in Experimental neurology (01.10.2009)
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Journal Article
MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy
Valera, Elvira, Spencer, Brian, Mott, Jennifer, Trejo, Margarita, Adame, Anthony, Mante, Michael, Rockenstein, Edward, Troncoso, Juan C, Beach, Thomas G, Masliah, Eliezer, Desplats, Paula
Published in Frontiers in molecular neuroscience (17.10.2017)
Published in Frontiers in molecular neuroscience (17.10.2017)
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Journal Article
Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease
BIN TANG, BECANOVIC, Kristina, DESPLATS, Paula A, SPENCER, Brian, HILL, Austin M, CONNOLLY, Colum, MASLIAH, Eliezer, LEAVITT, Blair R, THOMAS, Elizabeth A
Published in Human molecular genetics (15.07.2012)
Published in Human molecular genetics (15.07.2012)
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