Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer
Hornburg, Milena, Desbois, Mélanie, Lu, Shan, Guan, Yinghui, Lo, Amy A., Kaufman, Susan, Elrod, Ashley, Lotstein, Alina, DesRochers, Teresa M., Munoz-Rodriguez, Jose L., Wang, Xingwei, Giltnane, Jennifer, Mayba, Oleg, Turley, Shannon J., Bourgon, Richard, Daemen, Anneleen, Wang, Yulei
Published in Cancer cell (12.07.2021)
Published in Cancer cell (12.07.2021)
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IL-18 Induces PD-1: Dependent Immunosuppression in Cancer
TERME, Magali, ULLRICH, Evelyn, PREVOST-BLONDEL, Armelle, KATO, Masashi, SCHULTZE, Joachim L, TARTOUR, Eric, KROEMER, Guido, CHAPUT, Nathalie, ZITVOGEL, Laurence, AYMERIC, Laetitia, MEINHARDT, Kathrin, DESBOIS, Mélanie, DELAHAYE, Nicolas, VIAUD, Sophie, RYFFEL, Bernard, YAGITA, Hideo, KAPLANSKI, Gilles
Published in Cancer research (Chicago, Ill.) (15.08.2011)
Published in Cancer research (Chicago, Ill.) (15.08.2011)
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Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25
Hannani, Dalil, Vétizou, Marie, Enot, David, Rusakiewicz, Sylvie, Chaput, Nathalie, Klatzmann, David, Desbois, Melanie, Jacquelot, Nicolas, Vimond, Nadège, Chouaib, Salem, Mateus, Christine, Allison, James P, Ribas, Antoni, Wolchok, Jedd D, Yuan, Jianda, Wong, Philip, Postow, Michael, Mackiewicz, Andrzej, Mackiewicz, Jacek, Schadendorff, Dirk, Jaeger, Dirk, Korman, Alan J, Bahjat, Keith, Maio, Michele, Calabro, Luana, Teng, Michele WL, Smyth, Mark J, Eggermont, Alexander, Robert, Caroline, Kroemer, Guido, Zitvogel, Laurence
Published in Cell research (01.02.2015)
Published in Cell research (01.02.2015)
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Journal Article
IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists
Desbois, Mélanie, Le Vu, Pauline, Coutzac, Clélia, Marcheteau, Elie, Béal, Coralie, Terme, Magali, Gey, Alain, Morisseau, Sébastien, Teppaz, Géraldine, Boselli, Lisa, Jacques, Yannick, Béchard, David, Tartour, Eric, Cassard, Lydie, Chaput, Nathalie
Published in The Journal of immunology (1950) (01.07.2016)
Published in The Journal of immunology (1950) (01.07.2016)
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Journal Article
IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment
Desbois, Mélanie, Béal, Coralie, Charrier, Mélinda, Besse, Benjamin, Meurice, Guillaume, Cagnard, Nicolas, Jacques, Yannick, Béchard, David, Cassard, Lydie, Chaput, Nathalie
Published in Journal for immunotherapy of cancer (01.06.2020)
Published in Journal for immunotherapy of cancer (01.06.2020)
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Journal Article
Oxazaphosphorines combined with immune checkpoint blockers: dose-dependent tuning between immune and cytotoxic effects
Delahousse, Julia, Skarbek, Charles, Desbois, Mélanie, Perfettini, Jean-Luc, Chaput, Nathalie, Paci, Angelo
Published in Journal for immunotherapy of cancer (11.08.2020)
Published in Journal for immunotherapy of cancer (11.08.2020)
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Journal Article
Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
Coutzac, Clélia, Jouniaux, Jean-Mehdi, Paci, Angelo, Schmidt, Julien, Mallardo, Domenico, Seck, Atmane, Asvatourian, Vahe, Cassard, Lydie, Saulnier, Patrick, Lacroix, Ludovic, Woerther, Paul-Louis, Vozy, Aurore, Naigeon, Marie, Nebot-Bral, Laetitia, Desbois, Mélanie, Simeone, Ester, Mateus, Christine, Boselli, Lisa, Grivel, Jonathan, Soularue, Emilie, Lepage, Patricia, Carbonnel, Franck, Ascierto, Paolo Antonio, Robert, Caroline, Chaput, Nathalie
Published in Nature communications (01.05.2020)
Published in Nature communications (01.05.2020)
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Journal Article
Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
Desbois, Mélanie, Udyavar, Akshata R., Ryner, Lisa, Kozlowski, Cleopatra, Guan, Yinghui, Dürrbaum, Milena, Lu, Shan, Fortin, Jean-Philippe, Koeppen, Hartmut, Ziai, James, Chang, Ching-Wei, Keerthivasan, Shilpa, Plante, Marie, Bourgon, Richard, Bais, Carlos, Hegde, Priti, Daemen, Anneleen, Turley, Shannon, Wang, Yulei
Published in Nature communications (04.11.2020)
Published in Nature communications (04.11.2020)
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Journal Article
711 IGM-7354 is an anti-PD-L1 IgM antibody and IL-15 cytokine fusion that enhances NK and CD8+ T cell proliferation and tumor cytotoxicity plus potently reverses T cell exhaustion
Giffon, Thierry, Desbois, Melanie, Ng, Dean, Yakkundi, Poonam, Manlusoc, Marigold, Oyasu, Miho, Rosete, Rodnie, Machado, Daniel, Calhoun, Susan, Kothambawala, Tasnim, Saini, Avneesh, Wang, Beatrice, Kotturi, Maya, Keyt, Bruce, Sinclair, Angus
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR+ NK cell levels correlate with disease outcome
Chaput, Nathalie, Flament, Caroline, Locher, Clara, Desbois, Mélanie, Rey, Annie, Rusakiewicz, Sylvie, Poirier-Colame, Vichnou, Pautier, Patricia, Le Cesne, Axel, Soria, Jean-Charles, Paci, Angelo, Rosenzwajg, Michelle, Klatzmann, David, Eggermont, Alexander, Robert, Caroline, Zitvogel, Laurence
Published in Oncoimmunology (01.02.2013)
Published in Oncoimmunology (01.02.2013)
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Journal Article
Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors
RUSAKIEWICZ, Sylvie, SEMERARO, Michaela, CHAIGNEAU, Loic, LE BRUN-LY, Valérie, DUBREUIL, Patrice, CREMER, Isabelle, CAIGNARD, Anne, POIRIER-COLAME, Vichnou, CHABA, Kariman, FLAMENT, Caroline, HALAMA, Niels, JÄGER, Dirk, SARABI, Matthieu, EGGERMONT, Alexander, BONVALOT, Sylvie, COMMO, Frédéric, TERRIER, Philippe, OPOLON, Paule, EMILE, Jean-François, COINDRE, Jean-Michel, KROEMER, Guido, CHAPUT, Nathalie, LE CESNE, Axel, DESBOIS, Mélanie, BLAY, Jean-Yves, ZITVOGEL, Laurence, LOCHER, Clara, MENDEZ, Rosa, VIMOND, Nadège, CONCHA, Angel, GARRIDO, Federico, ISAMBERT, Nicolas
Published in Cancer research (Chicago, Ill.) (15.06.2013)
Published in Cancer research (Chicago, Ill.) (15.06.2013)
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Journal Article
Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells
TERME, Magalj, ULIRICHL, Evelyn, LIEPING CHEN, MECHERI, Salaheddine, KAPLANSKI, Gilles, PREVOST-BLONDEL, Armelle, KATO, Masashi, SCHULTZE, Joachim L, TARTOUR, Eric, KROEMER, Guido, DEGLI-ESPOSTI, Mariapia, CHAPUT, Nathalie, AYMERIC, Laetitia, ZITVOGEL, Laurence, MEINHARDT, Kathrin, COUDERT, Jerome D, DESBOIS, Melanie, GHIRINGHELLI, François, VIAUD, Sophie, RYFFEL, Bernard, YAGITA, Hideo
Published in Cancer research (Chicago, Ill.) (01.06.2012)
Published in Cancer research (Chicago, Ill.) (01.06.2012)
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Journal Article
Natural killer cells in non-hematopoietic malignancies
Desbois, Mélanie, Rusakiewicz, Sylvie, Locher, Clara, Zitvogel, Laurence, Chaput, Nathalie
Published in Frontiers in immunology (01.01.2012)
Published in Frontiers in immunology (01.01.2012)
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Journal Article
Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity
Wang, Beatrice T., Kothambawala, Tasnim, Hart, Kevin C., Chen, Xingjie, Desbois, Melanie, Calhoun, Susan E., Yakkundi, Poonam, Rosete, Rodnie A., Cao, Yuan, Cha, Katie, Matthew, Thomas J., Wang, Ling, Hinton, Paul R., Leabman, Maya K., Hernandez, Genevive, Kotturi, Maya F., Humke, Eric W., Sinclair, Angus M., Keyt, Bruce A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 463: Integrated digital pathology and transcriptome analysis identifies molecular mediators of T cell exclusion in ovarian cancer
Desbois, Melanie, Udyavar, Akshata, Ryner, Lisa, Kozlowski, Cleopatra, Guan, Yinghui, Dürrbaum, Milena, Lu, Shan, Fortin, Jean-Philippe, Koeppen, Hartmut, Ziai, James, Chang, Ching-Wei, Lo, Amy, Keerthivasan, Shilpa, Plante, Marie, Bourgon, Richard, Bais, Carlos, Hegde, Priti, Daemen, Anneleen, Turley, Shannon, Wang, Yulei
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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