Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I
Schulte, Marius, Frick, Klaudia, Gnandt, Emmanuel, Jurkovic, Sascha, Burschel, Sabrina, Labatzke, Ramona, Aierstock, Karoline, Fiegen, Dennis, Wohlwend, Daniel, Gerhardt, Stefan, Einsle, Oliver, Friedrich, Thorsten
Published in Nature communications (11.06.2019)
Published in Nature communications (11.06.2019)
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Journal Article
An Electrostatic Steering Mechanism of Cdc42 Recognition by Wiskott-Aldrich Syndrome Proteins
Hemsath, Lars, Dvorsky, Radovan, Fiegen, Dennis, Carlier, Marie-France, Ahmadian, Mohammad Reza
Published in Molecular cell (28.10.2005)
Published in Molecular cell (28.10.2005)
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Journal Article
Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
Fiegen, Dennis, Haeusler, Lars-Christian, Blumenstein, Lars, Herbrand, Ulrike, Dvorsky, Radovan, Vetter, Ingrid R., Ahmadian, Mohammad R.
Published in The Journal of biological chemistry (06.02.2004)
Published in The Journal of biological chemistry (06.02.2004)
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Journal Article
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
Rübbelke, Martin, Fiegen, Dennis, Bauer, Margit, Binder, Florian, Hamilton, James, King, Jim, Thamm, Sven, Nar, Herbert, Zeeb, Markus
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2020)
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Journal Article
A hybrid screening approach for very small fragments - X-ray and Computational Screening on FKBP51
Draxler, Sebastian Wolfgang, Bauer, Margit, Eickmeier, Christian, Nadal, Simon, Nar, Herbert, Rangel, Daniel, Seeliger, Daniel, Zeeb, Markus, Fiegen, Dennis
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Journal Article
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule
Tautermann, Christofer S, Binder, Florian, Büttner, Frank H, Eickmeier, Christian, Fiegen, Dennis, Gross, Ulrike, Grundl, Marc A, Heilker, Ralf, Hobson, Scott, Hoerer, Stefan, Luippold, Andreas, Mack, Volker, Montel, Florian, Peters, Stefan, Bhattacharya, Supriyo, Vaidehi, Nagarajan, Schnapp, Gisela, Thamm, Sven, Zeeb, Markus
Published in Journal of medicinal chemistry (10.01.2019)
Published in Journal of medicinal chemistry (10.01.2019)
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Journal Article
Redox-gated NADH oxidation of respiratory complex I
Jurkovic, Sascha, Frick, Klaudia, Schulte, Marius, Labatzke, Ramona, Aierstock, Karoline, Fiegen, Dennis, Gerhardt, Stefan, Einsle, Oliver, Friedrich, Thorsten
Published in Biochimica et biophysica acta. Bioenergetics (01.08.2016)
Published in Biochimica et biophysica acta. Bioenergetics (01.08.2016)
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Journal Article
MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput
Simon, Roman P., Winter, Martin, Kleiner, Carola, Wehrle, Lucie, Karnath, Michael, Ries, Robert, Zeeb, Markus, Schnapp, Gisela, Fiegen, Dennis, Häbe, Tim T., Runge, Frank, Bretschneider, Tom, Luippold, Andreas H., Bischoff, Daniel, Reindl, Wolfgang, Büttner, Frank H.
Published in SLAS discovery (01.01.2021)
Published in SLAS discovery (01.01.2021)
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Journal Article
A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state
Schnapp, Gisela, Neubauer, Heike, Büttner, Frank H., Handschuh, Sandra, Lingard, Iain, Heilker, Ralf, Klinder, Klaus, Prestle, Jürgen, Walter, Rainer, Wolff, Michael, Zeeb, Markus, Debaene, Francois, Nar, Herbert, Fiegen, Dennis
Published in Communications chemistry (10.06.2020)
Published in Communications chemistry (10.06.2020)
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Journal Article
Crystal structure of Rnd3/RhoE: functional implications
Fiegen, Dennis, Blumenstein, Lars, Stege, Patricia, Vetter, Ingrid R, Ahmadian, Mohammad Reza
Published in FEBS letters (14.08.2002)
Published in FEBS letters (14.08.2002)
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Journal Article
Crystal structure of Rnd3/RhoE: functional implications 1
Fiegen, Dennis, Blumenstein, Lars, Stege, Patricia, Vetter, Ingrid R, Ahmadian, Mohammad Reza
Published in FEBS letters (14.08.2002)
Published in FEBS letters (14.08.2002)
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Journal Article
Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b
Haeusler, Lars Christian, Hemsath, Lars, Fiegen, Dennis, Blumenstein, Lars, Herbrand, Ulrike, Stege, Patricia, Dvorsky, Radovan, Ahmadian, Mohammad Reza
Published in Methods in enzymology (2006)
Published in Methods in enzymology (2006)
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Journal Article
1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO [3,4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS
FIEGEN, DENNIS, FUCHS, KLAUS, DOERNER-CIOSSEK, CORNELIA, SCHAENZLE, GERHARD, EICKMEIER, CHRISTIAN, FOX, THOMAS, HEINE, NIKLAS, ROSENBROCK, HOLGER, GIOVANNINI, RICCARDO
Year of Publication 28.01.2021
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Year of Publication 28.01.2021
Patent
piperazino-diidroteinopirimidinas substituídas com heterociclo
Pascale Pouzet, Peter Nickolaus, RALF ANDERSKEWITZ, Rolf Goeggel, Christoph Hoenke, Dennis Fiegen, Domnic Martyres, Horst Dollinger, Klaus Klinder, Thomas Fox
Year of Publication 24.09.2019
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Year of Publication 24.09.2019
Patent