An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
Kurtz, Caroline B, Millet, Yves A, Puurunen, Marja K, Perreault, Mylène, Charbonneau, Mark R, Isabella, Vincent M, Kotula, Jonathan W, Antipov, Eugene, Dagon, Yossi, Denney, William S, Wagner, David A, West, Kip A, Degar, Andrew J, Brennan, Aoife M, Miller, Paul F
Published in Science translational medicine (16.01.2019)
Published in Science translational medicine (16.01.2019)
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AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients
Kaufman, Allegra, Abuqayyas, Lubna, Denney, William S., Tillman, Erik J., Rolph, Tim
Published in Cell reports. Medicine (21.07.2020)
Published in Cell reports. Medicine (21.07.2020)
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Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study
Leu, Jocelyn H, Vermeulen, An, Abbes, Claudia, Arroyo, Santiago, Denney, William S, Ling, Leona E
Published in Frontiers in neuroscience (01.02.2024)
Published in Frontiers in neuroscience (01.02.2024)
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Pharmacokinetics and pharmacodynamics of PF‐05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects
Denney, William S., Sonnenberg, Gabriele E., Carvajal‐Gonzalez, Santos, Tuthill, Theresa, Jackson, V. Margaret
Published in British journal of clinical pharmacology (01.02.2017)
Published in British journal of clinical pharmacology (01.02.2017)
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The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers
Perreault, Mylène, Means, Jillian, Gerson, Erik, James, Michael, Cotton, Sean, Bergeron, Christopher G., Simon, Mark, Carlin, Dylan Alexander, Schmidt, Nathan, Moore, Theodore C., Blasbalg, Julie, Sondheimer, Neal, Ndugga-Kabuye, Kenneth, Denney, William S., Isabella, Vincent M., Lubkowicz, David, Brennan, Aoife, Hava, David L.
Published in Cell host & microbe (13.03.2024)
Published in Cell host & microbe (13.03.2024)
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Variability and Lability of Ammonia Levels in Healthy Volunteers and Patients With Cirrhosis: Implications for Trial Design and Clinical Practice
Bajaj, Jasmohan S, Bloom, Patricia Pringle, Chung, Raymond T, Hassanein, Tarek I, Padilla-Martinez, Marielys, Kayali, Zeid, Rockey, Don C, Sasso, Roula, Muthukumar, Alagar R, Lee, William M, Denney, William S, Gavis, Edith A, Anderson, Cami, Blankstein, Larry, Brennan, Aoife M, Puurunen, Marja K, Lawitz, Eric
Published in The American journal of gastroenterology (01.05.2020)
Published in The American journal of gastroenterology (01.05.2020)
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Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs
Siebenga, Pieter S., Amerongen, Guido, Okkerse, Pieter, Denney, William S., Dua, Pinky, Butt, Richard P., Hay, Justin L., Groeneveld, Geert J.
Published in European journal of pain (01.07.2019)
Published in European journal of pain (01.07.2019)
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An updated Alzheimer’s disease progression model: incorporating non-linearity, beta regression, and a third-level random effect in NONMEM
Conrado, Daniela J., Denney, William S., Chen, Danny, Ito, Kaori
Published in Journal of pharmacokinetics and pharmacodynamics (01.12.2014)
Published in Journal of pharmacokinetics and pharmacodynamics (01.12.2014)
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Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow
Okorie, Uzoma M., Denney, William S., Chatterjee, Manash S., Neeves, Keith B., Diamond, Scott L.
Published in Blood (01.04.2008)
Published in Blood (01.04.2008)
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Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
Charbonneau, Mark R., Denney, William S., Horvath, Nicholas G., Cantarella, Pasquale, Castillo, Mary J., Puurunen, Marja K., Brennan, Aoife M.
Published in Communications biology (22.07.2021)
Published in Communications biology (22.07.2021)
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Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses
Shane, Sarah E., Langston, Vernon C., Wills, Robert W., Denney, William S., Knych, Heather, Fontenot, Robin L., Meyer, Robert E., Natalini, Claudio C.
Published in Journal of veterinary pharmacology and therapeutics (01.07.2021)
Published in Journal of veterinary pharmacology and therapeutics (01.07.2021)
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Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial
Vockley, Jerry, Sondheimer, Neal, Puurunen, Marja, Diaz, George A, Ginevic, Ilona, Grange, Dorothy K, Harding, Cary, Northrup, Hope, Phillips, 3rd, John A, Searle, Shawn, Thomas, Janet A, Zori, Roberto, Denney, William S, Ernst, Sharon L, Humphreys, Kristina, McWhorter, Nicole, Kurtz, Caroline, Brennan, Aoife M
Published in Nature metabolism (01.10.2023)
Published in Nature metabolism (01.10.2023)
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Translational Development of Microbiome‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates
Kurtz, Caroline, Denney, William S., Blankstein, Larry, Guilmain, Sarah E., Machinani, Suman, Kotula, Jonathan, Saha, Saurabh, Miller, Paul, Brennan, Aoife M.
Published in Clinical and translational science (01.03.2018)
Published in Clinical and translational science (01.03.2018)
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Comparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis
Woodward, Matthew R., Kardon, Adam, Manners, Jody, Schleicher, Samantha, Pergakis, Melissa B., Ciryam, Prajwal, Podell, Jamie, Denney Zimmerman, William, Galvagno, Samuel M., Butt, Bilal, Pritchard, Jennifer, Parikh, Gunjan Y., Gilmore, Emily J., Badjatia, Neeraj, Morris, Nicholas A.
Published in Epilepsy & behavior reports (01.01.2024)
Published in Epilepsy & behavior reports (01.01.2024)
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Transitions of Care Coordination Intervention Identifies Barriers to Discharge in Hospitalized Stroke Patients
Zimmerman, William Denney, Grenier, Rachel E., Palka, Sydney V., Monacci, Kelsey J., Lantzy, Amanda K., Leutbecker, Jacqueline A., Geng, Xue, Denny, Mary Carter
Published in Frontiers in neurology (17.05.2021)
Published in Frontiers in neurology (17.05.2021)
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Inhibition of capsaicin‐induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK‐0974)
Sinclair, Simon R., Kane, Stefanie A., Van der Schueren, Bart J., Xiao, Alan, Willson, Kenneth J., Boyle, Janet, De Lepeleire, Inge, Xu, Yang, Hickey, Lisa, Denney, William S., Li, Chi‐Chung, Palcza, John, Vanmolkot, Floris H. M., Depré, Marleen, Van Hecken, Anne, Murphy, M. Gail, Ho, Tony W., De Hoon, Jay N.
Published in British journal of clinical pharmacology (01.01.2010)
Published in British journal of clinical pharmacology (01.01.2010)
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Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients
Reitman, Marc L, Dishy, Victor, Moreau, Allison, Denney, William S, Liu, Chengcheng, Kraft, Walter K, Mejia, Alex V, Matson, Mark A, Stoch, S Aubrey, Wagner, John A, Lai, Eseng
Published in Journal of clinical pharmacology (01.09.2012)
Published in Journal of clinical pharmacology (01.09.2012)
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Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator
Sharma, Raman, Litchfield, John, Atkinson, Karen, Eng, Heather, Amin, Neeta B, Denney, William S, Pettersen, John C, Goosen, Theunis C, Di, Li, Lee, Esther, Pfefferkorn, Jeffrey A, Dalvie, Deepak K, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.11.2014)
Published in Drug metabolism and disposition (01.11.2014)
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