Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF 1) receptor antagonist with improved pharmacokinetic properties
Tellew, John E., Lanier, Marion, Moorjani, Manisha, Lin, Emily, Luo, Zhiyong, Slee, Deborah H., Zhang, Xiaohu, Hoare, Sam R.J., Grigoriadis, Dimitri E., Denis, Yves St, Fabio, Romano Di, Modugno, Enza Di, Saunders, John, Williams, John P.
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Discovery Process and Characterization of Novel Carbohydrazide Derivatives as Potent and Selective GHSR1a Antagonists
Sabbatini, Fabio Maria, Di Fabio, Romano, Corsi, Mauro, Cavanni, Paolo, Bromidge, Steve M., St-Denis, Yves, D'Adamo, Lucilla, Contini, Stefania, Rinaldi, Marilisa, Guery, Sebastien, Savoia, Chiara, Mundi, Claudia, Perini, Benedetta, Carpenter, Andrew J., Dal Forno, Giovanna, Faggioni, Federico, Tessari, Michela, Pavone, Francesca, Di Francesco, Carla, Buson, Alberto, Mattioli, Mario, Perdona', Elisabetta, Melotto, Sergio
Published in ChemMedChem (03.09.2010)
Published in ChemMedChem (03.09.2010)
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK1 receptor antagonists
SABBATINI, Fabio M, DI FABIO, Romano, DENIS, Yves St, COSTA, Silvano, CORSI, Mauro, GRIFFANTE, Cristiana, PENTASSUGLIA, Giorgio, ZONZINI, Laura, MELOTTO, Sergio, ALVARO, Giuseppe, CAPELLI, Anna M, PIPPO, Lara, PERDONA, Elisabetta
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Palladium-Catalyzed Heteroaromatic Couplings Mediated by Microwave Irradiation
Panunzio, Mauro, Tamanini, Emiliano, St-Denis, Yves, Maria Sabbatini, Fabio, Di Fabio, Romano, Xia, Zhining
Published in Synthetic communications (01.12.2007)
Published in Synthetic communications (01.12.2007)
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Heteroaryl-Substituted 4-(1H-pyrazol-1-yl)-5,6-dihydro-1H-pyrrolo[2,3-d]pyrimidine Derivatives as Potent and Selective Corticotropin-Releasing Factor Receptor-1 Antagonists
Sabbatini, Fabio Maria, Di Fabio, Romano, St-Denis, Yves, Capelli, Anna-Maria, Castiglioni, Emiliano, Contini, Stefania, Donati, Daniele, Fazzolari, Elettra, Gentile, Gabriella, Micheli, Fabrizio, Pavone, Francesca, Rinaldi, Marilisa, Pasquarello, Alessandra, Zampori, Maria Grazia, Di Felice, Pina, Zarantonello, Paola, Arban, Roberto, Perini, Benedetta, Vitulli, Giovanni, Benedetti, Roberto, Oliosi, Beatrice, Worby, Angela
Published in ChemMedChem (15.02.2008)
Published in ChemMedChem (15.02.2008)
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Cyclopenta[d]pyrimidines and Dihydropyrrolo[2,3-d]pyrimidines as Potent and Selective Corticotropin-Releasing Factor 1 Receptor Antagonists
Arban, Roberto, Benedetti, Roberto, Bonanomi, Giorgio, Capelli, Anna-Maria, Castiglioni, Emiliano, Contini, Stefania, Degiorgis, Fabio, Di Felice, Pina, Donati, Daniele, Fazzolari, Elettra, Gentile, Gabriella, Marchionni, Chiara, Marchioro, Carla, Messina, Flavia, Micheli, Fabrizio, Oliosi, Beatrice, Pavone, Francesca, Pasquarello, Alessandra, Perini, Benedetta, Rinaldi, Marilisa, Sabbatini, Fabio M., Vitulli, Giovanni, Zarantonello, Paola, Di Fabio, Romano, St-Denis, Yves
Published in ChemMedChem (16.04.2007)
Published in ChemMedChem (16.04.2007)
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The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1
Cody, Wayne L., Cai, Cuiman, Doherty, Annette M., Edmunds, Jeremy J., He, John X., Narasimhan, Lakshmi S., Plummer, Janet S., Rapundalo, Stephen T., Rubin, J. Ronald, Van Huis, Chad A., St-Denis, Yves, Winocour, Peter D., Siddiqui, M. Arshad
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
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Novel substituted tetrahydrotriazaacenaphthylene derivatives as potent CRF1 receptor antagonists
GENTILE, Gabriella, DI FABIO, Romano, PAVONE, Francesca, SABBATINI, Fabio Maria, ST-DENIS, Yves, GRAZIA ZAMPORI, Maria, VITULLI, Giovanni, WORBY, Angela
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
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Dihydropyrrole[2,3-d]pyridine Derivatives as Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping of the Receptor Binding Pocket by in Silico Docking Studies
Di Fabio, Romano, Arban, Roberto, Bernasconi, Giovanni, Braggio, Simone, Blaney, Frank E, Capelli, Anna M, Castiglioni, Emiliano, Donati, Daniele, Fazzolari, Elettra, Ratti, Emiliangelo, Feriani, Aldo, Contini, Stefania, Gentile, Gabriella, Ghirlanda, Damiano, Sabbatini, Fabio M, Andreotti, Daniele, Spada, Simone, Marchioro, Carla, Worby, Angela, St-Denis, Yves
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK sub(1) receptor antagonists
Sabbatini, Fabio M, Di Fabio, Romano, Griffante, Cristiana, Pentassuglia, Giorgio, Zonzini, Laura, Melotto, Sergio, Alvaro, Giuseppe, Capelli, Anna M, Pippo, Lara, Perdona', Elisabetta, St Denis, Yves, Costa, Silvano, Corsi, Mauro
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK 1 receptor antagonists
Sabbatini, Fabio M., Fabio, Romano Di, Griffante, Cristiana, Pentassuglia, Giorgio, Zonzini, Laura, Melotto, Sergio, Alvaro, Giuseppe, Capelli, Anna M., Pippo, Lara, Perdona’, Elisabetta, Denis, Yves St, Costa, Silvano, Corsi, Mauro
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Discovery of NBI-77860/GSKS61679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties
TELLEW, John E, LANIER, Marion, DI FABIO, Romano, DI MODUGNO, Enza, SAUNDERS, John, WILLIAMS, John P, MOORJANI, Manisha, LIN, Emily, ZHIYONG LUO, SLEE, Deborah H, XIAOHU ZHANG, HOARE, Sam R. J, GRIGORIADIS, Dimitri E, DENIS, Yves St
Published in Bioorganic & medicinal chemistry letters (2010)
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Published in Bioorganic & medicinal chemistry letters (2010)
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Novel substituted tetrahydrotriazaacenaphthylene derivatives as potent CRF 1 receptor antagonists
Gentile, Gabriella, Di Fabio, Romano, Pavone, Francesca, Sabbatini, Fabio Maria, St-Denis, Yves, Zampori, Maria Grazia, Vitulli, Giovanni, Worby, Angela
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Heteroaryl‐Substituted 4‐(1 H ‐pyrazol‐1‐yl)‐5,6‐dihydro‐1 H ‐pyrrolo[2,3‐ d ]pyrimidine Derivatives as Potent and Selective Corticotropin‐Releasing Factor Receptor‐1 Antagonists
Sabbatini, Fabio Maria, Di Fabio, Romano, St‐Denis, Yves, Capelli, Anna‐Maria, Castiglioni, Emiliano, Contini, Stefania, Donati, Daniele, Fazzolari, Elettra, Gentile, Gabriella, Micheli, Fabrizio, Pavone, Francesca, Rinaldi, Marilisa, Pasquarello, Alessandra, Zampori, Maria Grazia, Di Felice, Pina, Zarantonello, Paola, Arban, Roberto, Perini, Benedetta, Vitulli, Giovanni, Benedetti, Roberto, Oliosi, Beatrice, Worby, Angela
Published in ChemMedChem (15.02.2008)
Published in ChemMedChem (15.02.2008)
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Novel bicyclic lactam inhibitors of thrombin: Highly potent and selective inhibitors
ST-DENIS, Yves, LEVESQUE, Sophie, BACHAND, Benoit, EDMUNDS, Jeremy J, LEBLOND, Lorraine, PREVILLE, Patrice, TARAZI, Micheline, WINOCOUR, Peter D, SIDDIQUI, M. Arshad
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists
Sabbatini, Fabio M, Di Fabio, Romano, Griffante, Cristiana, Pentassuglia, Giorgio, Zonzini, Laura, Melotto, Sergio, Alvaro, Giuseppe, Capelli, Anna M, Pippo, Lara, Perdona', Elisabetta, St Denis, Yves, Costa, Silvano, Corsi, Mauro
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: Transition state inhibitors
BACHAND, Benoit, TARAZI, Micheline, ST-DENIS, Yves, EDMUNDS, Jeremy J, WINOCOUR, Peter D, LEBLOND, Lorraine, SIDDIQUI, M. Arshad
Published in Bioorganic & medicinal chemistry letters (12.02.2001)
Published in Bioorganic & medicinal chemistry letters (12.02.2001)
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Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues
Lévesque, Sophie, St-Denis, Yves, Bachand, Benoit, Préville, Patrice, Leblond, Lorraine, Winocour, Peter D, Edmunds, Jeremy J, Rubin, J.R, Siddiqui, M.Arshad
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
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