PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER
Vang, Amanda G, Ben-Sasson, Shlomo Z, Dong, Hongli, Kream, Barbara, DeNinno, Michael P, Claffey, Michelle M, Housley, William, Clark, Robert B, Epstein, Paul M, Brocke, Stefan
Published in PloS one (09.08.2010)
Published in PloS one (09.08.2010)
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Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response
McClure, Kim F, Darout, Etzer, Guimarães, Cristiano R. W, DeNinno, Michael P, Mascitti, Vincent, Munchhof, Michael J, Robinson, Ralph P, Kohrt, Jeffrey, Harris, Anthony R, Moore, Dianna E, Li, Bryan, Samp, Lacey, Lefker, Bruce A, Futatsugi, Kentaro, Kung, Daniel, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Salter, Eben, Hornby, Sam, Kalgutkar, Amit S, Chen, Yue
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
DeNinno, Michael P., Andrews, Melissa, Bell, Andrew S., Chen, Yue, Eller-Zarbo, Cynthia, Eshelby, Nan, Etienne, John B., Moore, Dianna E., Palmer, Michael J., Visser, Michael S., Yu, Li J., Zavadoski, William J., Michael Gibbs, E.
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Synthesis of Fused Bicyclic Piperidines: Potential Bioactive Templates for Medicinal Chemistry
Zhou, Jinglan, Campbell-Conroy, Erica L, Silina, Alina, Uy, Johnny, Pierre, Fabrice, Hurley, Dennis J, Hilgraf, Nicole, Frieman, Bryan A, DeNinno, Michael P
Published in Journal of organic chemistry (02.01.2015)
Published in Journal of organic chemistry (02.01.2015)
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From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
Futatsugi, Kentaro, Mascitti, Vincent, Guimarães, Cristiano R.W., Morishita, Nao, Cai, Cuiman, DeNinno, Michael P., Gao, Hua, Hamilton, Michael D., Hank, Richard, Harris, Anthony R., Kung, Daniel W., Lavergne, Sophie Y., Lefker, Bruce A., Lopaze, Michael G., McClure, Kim F., Munchhof, Michael J., Preville, Cathy, Robinson, Ralph P., Wright, Stephen W., Bonin, Paul D., Cornelius, Peter, Chen, Yue, Kalgutkar, Amit S.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes
DeNinno, Michael P., Wright, Stephen W., Etienne, John B., Olson, Thanh V., Rocke, Benjamin N., Corbett, Jeffrey W., Kung, Daniel W., DiRico, Kenneth J., Andrews, Kim M., Millham, Michele L., Parker, Janice C., Esler, William, van Volkenburg, Maria, Boyer, David D., Houseknecht, Karen L., Doran, Shawn D.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Journal Article
1,5-Substituted nipecotic amides: Selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability
DeNinno, Michael P., Wright, Stephen W., Visser, Michael S., Etienne, John B., Moore, Dianna E., Olson, Thanh V., Rocke, Benjamin N., Andrews, Melissa P., Zarbo, Cynthia, Millham, Michele L., Boscoe, Brian P., Boyer, David D., Doran, Shawn D., Houseknecht, Karen L.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes
YU, Li J, YUE CHEN, DENINNO, Michael P, O'CONNELL, Thomas N, HOP, Cornelis E. C. A
Published in Drug metabolism and disposition (01.04.2005)
Published in Drug metabolism and disposition (01.04.2005)
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Stereoselective total syntheses of the naturally occurring enantiomers of N-acetylneuraminic acid and 3-deoxy-D-manno-2-octulosonic acid. A new and stereospecific approach to sialo and 3-deoxy-D-manno-2-octulosonic acid conjugates
Danishefsky, Samuel J, DeNinno, Michael P, Chen, Shu Hui
Published in Journal of the American Chemical Society (01.06.1988)
Published in Journal of the American Chemical Society (01.06.1988)
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Journal Article
Differing cardioprotective efficacy of the Na+/Ca2+ exchanger inhibitors SEA0400 and KB-R7943
Magee, William P, Deshmukh, Gayatri, Deninno, Michael P, Sutt, Jill C, Chapman, Justin G, Tracey, W. Ross
Published in American journal of physiology. Heart and circulatory physiology (01.03.2003)
Published in American journal of physiology. Heart and circulatory physiology (01.03.2003)
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A method for the selective reduction of carbohydrate 4,6- O-benzylidene acetals
DeNinno, Michael P., Etienne, John B., Duplantier, Kimberly C.
Published in Tetrahedron letters (01.01.1995)
Published in Tetrahedron letters (01.01.1995)
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3‘-Aminoadenosine-5‘-uronamides: Discovery of the First Highly Selective Agonist at the Human Adenosine A3 Receptor
DeNinno, Michael P, Masamune, Hiroko, Chenard, Lois K, DiRico, Kenneth J, Eller, Cynthia, Etienne, John B, Tickner, Jeanene E, Kennedy, Scott P, Knight, Delvin R, Kong, Jimmy, Oleynek, Joseph J, Tracey, W. Ross, Hill, Roger J
Published in Journal of medicinal chemistry (30.01.2003)
Published in Journal of medicinal chemistry (30.01.2003)
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Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor
DeNinno, Michael P, Schoenleber, Robert, Perner, Richard J, Lijewski, Linda, Asin, Karen E, Britton, Donald R, MacKenzie, Robert, Kebabian, John W
Published in Journal of medicinal chemistry (01.08.1991)
Published in Journal of medicinal chemistry (01.08.1991)
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Journal Article
The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor
DENINNO, Michael P, MASAMUNE, Hiroko, OLEYNEK, Joseph J, TRACEY, W. Ross, HILL, Roger J, CHENARD, Lois K, DIRICO, Kenneth J, ELLER, Cynthia, ETIENNE, John B, TICKNER, Jeanene E, KENNEDY, Scott P, KNIGHT, Delvin R, KONG, Jimmy
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Comparison of synthetic saponin cholesterol absorption inhibitors in rabbits: evidence for a non-stoichiometric, intestinal mechanism of action
Morehouse, L.A, Bangerter, F.W, DeNinno, M.P, Inskeep, P.B, McCarthy, P.A, Pettini, J.L, Savoy, Y.E, Sugarman, E.D, Wilkins, R.W, Wilson, T.C
Published in Journal of lipid research (01.03.1999)
Published in Journal of lipid research (01.03.1999)
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