A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors
Yu, Yang, Xu, Tingyang, Li, Jiawen, Qiu, Yaping, Rong, Yu, Gong, Zhen, Cheng, Xuemin, Dong, Liming, Liu, Wei, Li, Jin, Dou, Dengfeng, Huang, Junzhou
Published in ACS omega (07.09.2021)
Published in ACS omega (07.09.2021)
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Inhibition of noroviruses by piperazine derivatives
Dou, Dengfeng, He, Guijia, Mandadapu, Sivakoteswara Rao, Aravapalli, Sridhar, Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Amino Acid-Derived 1,2-Benzisothiazolinone Derivatives as Novel Small-Molecule Antifungal Inhibitors: Identification of Potential Genetic Targets
ALEX, Deepu, GAY-ANDRIEU, Francoise, MAY, Jared, THAMPI, Linta, DENGFENG DOU, MOONEY, Aileen, GROUTAS, William, CALDERONE, Richard
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
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Antifungal activity of a series of 1,2-benzisothiazol-3(2 H)-one derivatives
Dou, Dengfeng, Alex, Deepu, Du, Bingfan, Tiew, Kok-Chuan, Aravapalli, Sridhar, Mandadapu, Sivakoteswara Rao, Calderone, Richard, Groutas, William C.
Published in Bioorganic & medicinal chemistry (01.10.2011)
Published in Bioorganic & medicinal chemistry (01.10.2011)
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Potent inhibition of Norwalk virus by cyclic sulfamide derivatives
Dou, Dengfeng, Tiew, Kok-Chuan, He, Guijia, Mandadapu, Sivakoteswara Rao, Aravapalli, Sridhar, Alliston, Kevin R., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Published in Bioorganic & medicinal chemistry (15.10.2011)
Published in Bioorganic & medicinal chemistry (15.10.2011)
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Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives
Tiew, Kok-Chuan, Dou, Dengfeng, Teramoto, Tadahisa, Lai, Huiguo, Alliston, Kevin R., Lushington, Gerald H., Padmanabhan, R., Groutas, William C.
Published in Bioorganic & medicinal chemistry (01.02.2012)
Published in Bioorganic & medicinal chemistry (01.02.2012)
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Dual function inhibitors of relevance to chronic obstructive pulmonary disease
Dou, Dengfeng, He, Guijia, Alliston, Kevin R., Groutas, William C.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3
Dou, Dengfeng, He, Guijia, Li, Yi, Lai, Zhong, Wei, Liuqing, Alliston, Kevin R., Lushington, Gerald H., Eichhorn, David M., Groutas, William C.
Published in Bioorganic & medicinal chemistry (01.02.2010)
Published in Bioorganic & medicinal chemistry (01.02.2010)
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X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives
Huang, Weijun, Yamamoto, Yasufumi, Li, Yi, Dou, Dengfeng, Alliston, Kevin R, Hanzlik, Robert P, Williams, Todd D, Groutas, William C
Published in Journal of medicinal chemistry (10.04.2008)
Published in Journal of medicinal chemistry (10.04.2008)
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Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase
Dou, Dengfeng, He, Guijia, Kuang, Rongze, Fu, Qingfong, Venkataraman, Radhika, Groutas, William C.
Published in Bioorganic & medicinal chemistry (15.09.2010)
Published in Bioorganic & medicinal chemistry (15.09.2010)
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Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA
Chen, Qiuxia, Li, You, Lin, Chunrong, Chen, Liu, Luo, Hao, Xia, Shuai, Liu, Chuan, Cheng, Xuemin, Liu, Chengzhong, Li, Jin, Dou, Dengfeng
Published in Nucleic acids research (08.07.2022)
Published in Nucleic acids research (08.07.2022)
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Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach
Chen, Qiuxia, Liu, Chuan, Wang, Wei, Meng, Xiaoyun, Cheng, Xuemin, Li, Xianyang, Cai, Longying, Luo, Linfu, He, Xu, Qu, Huan, Luo, Jing, Wei, Hong, Gao, Sen, Liu, Guansai, Wan, Jinqiao, Israel, David I., Li, Jin, Dou, Dengfeng
Published in ACS chemical biology (20.01.2023)
Published in ACS chemical biology (20.01.2023)
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Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs
Liu, Chuan, Chen, Zhonghui, Chen, Tao, Song, Hongmei, Shen, Jianbo, Yuan, Xiaoxi, Xia, Shuai, Liu, Qian, Chen, Qiuxia, Tian, Qiang, Meng, Xiaoyun, Han, Zhu, Dong, Xiaofei, Yang, Yu, Cai, Longying, Cheng, Xuemin, Jia, Yangyang, Liu, Guansai, Li, Jin, Ge, Junyou, Dou, Dengfeng
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening
Hartman, George, Humphries, Paul, Hughes, Robert, Ho, Andrew, Montgomery, Rusty, Deshpande, Aditi, Mahanta, Maitriyee, Tronnes, Sarah, Cowdin, Samantha, He, Xu, Liu, Fangchao, Zhang, Lifang, Liu, Chuan, Dou, Dengfeng, Li, Jin, Spasic, Aleksander, Coll, Rebecca, Marleaux, Michael, Hochheiser, Inga V., Geyer, Matthias, Rubin, Paul, Fortney, Kristen, Wilhelmsen, Kevin
Published in Bioorganic & medicinal chemistry letters (01.04.2024)
Published in Bioorganic & medicinal chemistry letters (01.04.2024)
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Neutrophil elastase inhibitors
Groutas, William C, Dou, Dengfeng, Alliston, Kevin R
Published in Expert opinion on therapeutic patents (01.03.2011)
Published in Expert opinion on therapeutic patents (01.03.2011)
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