Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy
Jiang, Hong, Hegde, Samarth, DeNardo, David G.
Published in Cancer Immunology, Immunotherapy (01.08.2017)
Published in Cancer Immunology, Immunotherapy (01.08.2017)
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A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, Erik, Astsaturov, Igor, Cukierman, Edna, DeNardo, David G., Egeblad, Mikala, Evans, Ronald M., Fearon, Douglas, Greten, Florian R., Hingorani, Sunil R., Hunter, Tony, Hynes, Richard O., Jain, Rakesh K., Janowitz, Tobias, Jorgensen, Claus, Kimmelman, Alec C., Kolonin, Mikhail G., Maki, Robert G., Powers, R. Scott, Puré, Ellen, Ramirez, Daniel C., Scherz-Shouval, Ruth, Sherman, Mara H., Stewart, Sheila, Tlsty, Thea D., Tuveson, David A., Watt, Fiona M., Weaver, Valerie, Weeraratna, Ashani T., Werb, Zena
Published in Nature reviews. Cancer (01.03.2020)
Published in Nature reviews. Cancer (01.03.2020)
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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G
Published in Nature medicine (01.08.2016)
Published in Nature medicine (01.08.2016)
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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
Hegde, Samarth, Krisnawan, Varintra E., Herzog, Brett H., Zuo, Chong, Breden, Marcus A., Knolhoff, Brett L., Hogg, Graham D., Tang, Jack P., Baer, John M., Mpoy, Cedric, Lee, Kyung Bae, Alexander, Katherine A., Rogers, Buck E., Murphy, Kenneth M., Hawkins, William G., Fields, Ryan C., DeSelm, Carl J., Schwarz, Julie K., DeNardo, David G.
Published in Cancer cell (16.03.2020)
Published in Cancer cell (16.03.2020)
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Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
DeNardo, David G., Andreu, Pauline, Coussens, Lisa M.
Published in Cancer and metastasis reviews (01.06.2010)
Published in Cancer and metastasis reviews (01.06.2010)
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Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
Nywening, Timothy M, MD, Wang-Gillam, Andrea, MD, Sanford, Dominic E, MD, Belt, Brian A, MA, Panni, Roheena Z, MD, Cusworth, Brian M, BA, Toriola, Adetunji T, MD, Nieman, Rebecca K, MS, Worley, Lori A, BS, Yano, Motoyo, MD, Fowler, Kathryn J, MD, Lockhart, A Craig, MD, Suresh, Rama, MD, Tan, Benjamin R, MD, Lim, Kian-Huat, MD, Fields, Ryan C, MD, Strasberg, Steven M, Prof, Hawkins, William G, Prof, DeNardo, David G, PhD, Goedegebuure, S Peter, PhD, Linehan, David C, Dr Prof
Published in The lancet oncology (01.05.2016)
Published in The lancet oncology (01.05.2016)
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CD4 + T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages
DeNardo, David G., Barreto, Jairo B., Andreu, Pauline, Vasquez, Lesley, Tawfik, David, Kolhatkar, Nikita, Coussens, Lisa M.
Published in Cancer cell (04.08.2009)
Published in Cancer cell (04.08.2009)
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Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.
Published in Nature communications (08.06.2016)
Published in Nature communications (08.06.2016)
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CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
Zhu, Yu, Knolhoff, Brett L, Meyer, Melissa A, Nywening, Timothy M, West, Brian L, Luo, Jingqin, Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C, DeNardo, David G
Published in Cancer research (Chicago, Ill.) (15.09.2014)
Published in Cancer research (Chicago, Ill.) (15.09.2014)
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Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression
Zhu, Yu, Herndon, John M., Sojka, Dorothy K., Kim, Ki-Wook, Knolhoff, Brett L., Zuo, Chong, Cullinan, Darren R., Luo, Jingqin, Bearden, Audrey R., Lavine, Kory J., Yokoyama, Wayne M., Hawkins, William G., Fields, Ryan C., Randolph, Gwendalyn J., DeNardo, David G.
Published in Immunity (Cambridge, Mass.) (15.08.2017)
Published in Immunity (Cambridge, Mass.) (15.08.2017)
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Rethinking immune checkpoint blockade: ‘Beyond the T cell’
Liu, Xiuting, Hogg, Graham D, DeNardo, David G
Published in Journal for immunotherapy of cancer (01.01.2021)
Published in Journal for immunotherapy of cancer (01.01.2021)
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Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
Nywening, Timothy M, Belt, Brian A, Cullinan, Darren R, Panni, Roheena Z, Han, Booyeon J, Sanford, Dominic E, Jacobs, Ryan C, Ye, Jian, Patel, Ankit A, Gillanders, William E, Fields, Ryan C, DeNardo, David G, Hawkins, William G, Goedegebuure, Peter, Linehan, David C
Published in Gut (01.06.2018)
Published in Gut (01.06.2018)
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Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
MITCHEM, Jonathan B, BRENNAN, Donal J, HEWITT, Stephen, MALLYA UDUPI, Girish, GALLAGHER, William M, WEGNER, Craig, WEST, Brian L, WANG-GILLAM, Andrea, GOEDEGEBUURE, Peter, LINEHAN, David C, DENARDO, David G, KNOLHOFF, Brett L, BELT, Brian A, YU ZHU, SANFORD, Dominic E, BELAYGOROD, Larisa, CARPENTER, Danielle, COLLINS, Lynne, PIWNICA-WORMS, David
Published in Cancer research (Chicago, Ill.) (01.02.2013)
Published in Cancer research (Chicago, Ill.) (01.02.2013)
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Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
Meyer, Melissa A., Baer, John M., Knolhoff, Brett L., Nywening, Timothy M., Panni, Roheena Z., Su, Xinming, Weilbaecher, Katherine N., Hawkins, William G., Ma, Cynthia, Fields, Ryan C., Linehan, David C., Challen, Grant A., Faccio, Roberta, Aft, Rebecca L., DeNardo, David G.
Published in Nature communications (28.03.2018)
Published in Nature communications (28.03.2018)
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Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies
Panni, Roheena Z, Herndon, John M, Zuo, Chong, Hegde, Samarth, Hogg, Graham D, Knolhoff, Brett L, Breden, Marcus A, Li, Xiaobo, Krisnawan, Varintra E, Khan, Samia Q, Schwarz, Julie K, Rogers, Buck E, Fields, Ryan C, Hawkins, William G, Gupta, Vineet, DeNardo, David G
Published in Science translational medicine (03.07.2019)
Published in Science translational medicine (03.07.2019)
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Journal Article
Immune cells as mediators of solid tumor metastasis
DeNardo, David G., Johansson, Magnus, Coussens, Lisa M.
Published in Cancer and metastasis reviews (01.03.2008)
Published in Cancer and metastasis reviews (01.03.2008)
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Journal Article
Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner
Volk-Draper, Lisa, Hall, Kelly, Griggs, Caitlin, Rajput, Sandeep, Kohio, Pascaline, DeNardo, David, Ran, Sophia
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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