Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P5 receptor agonist chemotype
Stoit, Axel R., Lange, Jos H.M., Coolen, Hein K.A.C., Rensink, Annemieke, van den Hoogenband, Adri, den Hartog, Arnold P., van Schaik, Sjoerd, Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Journal Article
Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Lange, Jos H. M, Coolen, Hein K. A. C, van Stuivenberg, Herman H, Dijksman, Jessica A. R, Herremans, Arnoud H. J, Ronken, Eric, Keizer, Hiskias G, Tipker, Koos, McCreary, Andrew C, Veerman, Willem, Wals, Henri C, Stork, Bob, Verveer, Peter C, den Hartog, Arnold P, de Jong, Natasja M. J, Adolfs, Tiny J. P, Hoogendoorn, Jan, Kruse, Chris G
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Journal Article
Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Journal Article
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonists
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, DEN HARTOG, Arnold P, WALS, Henri C, HOOGENDOORN, Jan, VAN STUIVENBERG, Herman H, VAN VLIET, Bernard J, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, VAN VLIET, Bernard J, WALS, Henri C, KUIL, Gijs D, BORST, Alice J. M, MULDER, Arie, DEN HARTOG, Arnold P, ZILAOUT, Hicham, GOUTIER, Wouter, VAN STUIVENBERG, Herman H
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1H-indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition
Smid, Pieter, Coolen, Hein K. A. C, Keizer, Hiskias G, van Hes, Rolf, de Moes, Jan-Peter, den Hartog, Arnold P, Stork, Bob, Plekkenpol, Rob H, Niemann, Leonarda C, Stroomer, Cees N. J, Tulp, Martin Th. M, van Stuivenberg, Herman H, McCreary, Andrew C, Hesselink, Mayke B, Herremans, Arnoud H. J, Kruse, Chris G
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Journal Article
7-Azaindole derivatives as potential partial nicotinic agonists
Stoit, Axel R., den Hartog, Arnold P., Mons, Harry, van Schaik, Sjoerd, Barkhuijsen, Nynke, Stroomer, Cees, Coolen, Hein K.A.C., Reinders, Jan Hendrik, Adolfs, Tiny J.P., van der Neut, Martina, Keizer, Hiskias, Kruse, Chris G.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P(5) receptor agonist chemotype
Stoit, Axel R., Lange, Jos H. M., Coolen, Hein K. A. C., Rensink, Annemieke, van den Hoogenband, Adri, den Hartog, Arnold P., van Schaik, Sjoerd, Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Get full text
Journal Article
Optimization of N ′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT 6 antagonistic binding pocket
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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Journal Article
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P 5 receptor agonist chemotype
Stoit, Axel R, Lange, Jos H M, Coolen, Hein K A C, Rensink, Annemieke, van den Hoogenband, Adri, den Hartog, Arnold P, van Schaik, Sjoerd, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Get full text
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Journal Article
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB 1 receptor antagonists
Lange, Jos H.M., van der Neut, Martina A.W., den Hartog, Arnold P., Wals, Henri C., Hoogendoorn, Jan, van Stuivenberg, Herman H., van Vliet, Bernard J., Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB 2 receptor antagonists with high binding efficiencies
Lange, Jos H.M., van der Neut, Martina A.W., Wals, Henri C., Kuil, Gijs D., Borst, Alice J.M., Mulder, Arie, den Hartog, Arnold P., Zilaout, Hicham, Goutier, Wouter, van Stuivenberg, Herman H., van Vliet, Bernard J.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
Get full text
Journal Article
Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1 H -indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D 2 Receptor Antagonism with Potent Serotonin Reuptake Inhibition
Smid, Pieter, Coolen, Hein K. A. C., Keizer, Hiskias G., van Hes, Rolf, de Moes, Jan-Peter, den Hartog, Arnold P., Stork, Bob, Plekkenpol, Rob H., Niemann, Leonarda C., Stroomer, Cees N. J., Tulp, Martin Th. M., van Stuivenberg, Herman H., McCreary, Andrew C., Hesselink, Mayke B., Herremans, Arnoud H. J., Kruse, Chris G.
Published in Journal of medicinal chemistry (01.11.2005)
Published in Journal of medicinal chemistry (01.11.2005)
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Journal Article
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists
Lange, Jos H M, van der Neut, Martina A W, den Hartog, Arnold P, Wals, Henri C, Hoogendoorn, Jan, van Stuivenberg, Herman H, van Vliet, Bernard J, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists
Lange, Jos H M, Coolen, Hein K A C, van Stuivenberg, Herman H, Dijksman, Jessica A R, Herremans, Arnoud H J, Ronken, Eric, Keizer, Hiskias G, Tipker, Koos, McCreary, Andrew C, Veerman, Willem, Wals, Henri C, Stork, Bob, Verveer, Peter C, den Hartog, Arnold P, de Jong, Natasja M J, Adolfs, Tiny J P, Hoogendoorn, Jan, Kruse, Chris G
Published in Journal of medicinal chemistry (29.01.2004)
Get full text
Published in Journal of medicinal chemistry (29.01.2004)
Journal Article
Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB 1 Cannabinoid Receptor Antagonists
Lange, Jos H. M., Coolen, Hein K. A. C., van Stuivenberg, Herman H., Dijksman, Jessica A. R., Herremans, Arnoud H. J., Ronken, Eric, Keizer, Hiskias G., Tipker, Koos, McCreary, Andrew C., Veerman, Willem, Wals, Henri C., Stork, Bob, Verveer, Peter C., den Hartog, Arnold P., de Jong, Natasja M. J., Adolfs, Tiny J. P., Hoogendoorn, Jan, Kruse, Chris G.
Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
Get full text
Journal Article