The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade
Schaer, David A., Beckmann, Richard P., Dempsey, Jack A., Huber, Lysiane, Forest, Amelie, Amaladas, Nelusha, Li, Yanxia, Wang, Ying Cindy, Rasmussen, Erik R., Chin, Darin, Capen, Andrew, Carpenito, Carmine, Staschke, Kirk A., Chung, Linda A., Litchfield, Lacey M., Merzoug, Farhana F., Gong, Xueqian, Iversen, Philip W., Buchanan, Sean, de Dios, Alfonso, Novosiadly, Ruslan D., Kalos, Michael
Published in Cell reports (Cambridge) (13.03.2018)
Published in Cell reports (Cambridge) (13.03.2018)
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Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors
Zhu, Guoxin, Conner, Scott E, Zhou, Xun, Shih, Chuan, Li, Tiechao, Anderson, Bryan D, Brooks, Harold B, Campbell, Robert Morris, Considine, Eileen, Dempsey, Jack A, Faul, Margaret M, Ogg, Cathy, Patel, Bharvin, Schultz, Richard M, Spencer, Charles D, Teicher, Beverly, Watkins, Scott A
Published in Journal of medicinal chemistry (22.05.2003)
Published in Journal of medicinal chemistry (22.05.2003)
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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy
Du, Jian, Yan, Lei, Torres, Raquel, Gong, Xueqian, Bian, Huimin, Marugán, Carlos, Boehnke, Karsten, Baquero, Carmen, Hui, Yu-Hua, Chapman, Sonya C, Yang, Yanzhu, Zeng, Yi, Bogner, Sarah M, Foreman, Robert T, Capen, Andrew, Donoho, Gregory P, Van Horn, Robert D, Barnard, Darlene S, Dempsey, Jack A, Beckmann, Richard P, Marshall, Mark S, Chio, Li-Chun, Qian, Yuewei, Webster, Yue W, Aggarwal, Amit, Chu, Shaoyou, Bhattachar, Shobha, Stancato, Louis F, Dowless, Michele S, Iversen, Phillip W, Manro, Jason R, Walgren, Jennie L, Halstead, Bartley W, Dieter, Matthew Z, Martinez, Ricardo, Bhagwat, Shripad V, Kreklau, Emiko L, Lallena, Maria Jose, Ye, Xiang S, Patel, Bharvin K R, Reinhard, Christoph, Plowman, Gregory D, Barda, David A, Henry, James R, Buchanan, Sean G, Campbell, Robert M
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7- a]pyrrolo[3,4- c]carbazoles
Engler, Thomas A., Furness, Kelly, Malhotra, Sushant, Sanchez-Martinez, Concha, Shih, Chuan, Xie, Walter, Zhu, Guoxin, Zhou, Xun, Conner, Scott, Faul, Margaret M., Sullivan, Kevin A., Kolis, Stanley P., Brooks, Harold B., Patel, Bharvin, Schultz, Richard M., DeHahn, Tammy B., Kirmani, Kashif, Spencer, Charles D., Watkins, Scott A., Considine, Eileen L., Dempsey, Jack A., Ogg, Catherine A., Stamm, Nancy B., Anderson, Bryan D., Campbell, Robert M., Vasudevan, Vasu, Lytle, Michelle L.
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib
Blosser, Wayne D, Dempsey, Jack A, McNulty, Ann M, Rao, Xi, Ebert, Philip J, Lowery, Caitlin D, Iversen, Philip W, Webster, Yue Wang, Donoho, Gregory P, Gong, Xueqian, Merzoug, Farhana F, Buchanan, Sean, Boehnke, Karsten, Yu, Chunping, You, Xin Tian, Beckmann, Richard P, Wu, Wenjuan, McNeely, Samuel C, Lin, Aimee Bence, Martinez, Ricardo
Published in Oncotarget (21.01.2020)
Published in Oncotarget (21.01.2020)
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Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
Sanchez-Martinez, Concha, Shih, Chuan, Zhu, Guoxin, Li, Tiechao, Brooks, Harold B, Patel, Bharvin K R, Schultz, Richard M, DeHahn, Tammy B, Spencer, Charles D, Watkins, Scott A, Ogg, Catherine A, Considine, Eileen, Dempsey, Jack A, Zhang, Faming
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Journal Article
Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors
Zhu, Guoxin, Conner, Scott E., Zhou, Xun, Chan, Ho-Kit, Shih, Chuan, Engler, Thomas A., Al-awar, Rima S., Brooks, Harold B., Watkins, Scott A., Spencer, Charles D., Schultz, Richard M., Dempsey, Jack A., Considine, Eileen L., Patel, Bharvin R., Ogg, Catherine A., Vasudevan, Vasu, Lytle, Michelle L.
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors
SANCHEZ-MARTINEZ, Concha, SHIH, Chuan, BROOKS, Harold B, PATEL, Bharvin K. R, SCHULTZ, Richard M, DEHAHN, Tammy B, SPENCER, Charles D, WATKINS, Scott A, CONSIDINE, Eileen, DEMPSEY, Jack A, OGG, Catherine A, CAMPBELL, Robert M, FAUL, Margaret M, ANDERSON, Bryan A, WAGNER, Jill, GUOXIN ZHU, PAAL, Michael, SOMOZA, Carmen, TIECHAO LI, KUMRICH, Christine A, WINNEROSKI, Leonard L, ZHOU XUN
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Journal Article
Synthesis of quinolinyl/isoquinolinyl[ a]pyrrolo [3,4- c] carbazoles as cyclin D1/CDK4 inhibitors
Zhu, Guoxin, Conner, Scott, Zhou, Xun, Shih, Chuan, Brooks, Harold B., Considine, Eileen, Dempsey, Jack A., Ogg, Cathy, Patel, Bharvin, Schultz, Richard M., Spencer, Charles D., Teicher, Beverly, Watkins, Scott A.
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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Journal Article
Abstract 2535: Enhanced gene expression of replication fork and other E2F targets genes is associated with sensitivity and, paradoxically, also with acquired drug resistance, to the Chk1 inhibitor prexasertib
Blosser, Wayne D., Dempsey, Jack A., McNulty, Ann M., Wu, Wenjuan, Ebert, Philip J., Ting, Jason C., Webster, Yue W., Stewart, Trent R., Gong, Xueqian, Merzoug, Farhana F., Buchanan, Sean, Martinez, Ricardo
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract A12: The CDK4/CDK6 inhibitor abemaciclib inhibits transcriptional targets which facilitate growth in ER+ breast cancer cells
McNulty, Ann M., Burke, Teresa, Dempsey, Jack A., Marchal, Christophe C., Schade, Andrew E., Szpurka, Hadrian P., Dowless, Michele S., Stephens, Jennifer, Edmondson, Denise, Stayrook, Keith, Caldwell, William C., Buchanan, Sean, Merzoug, Farhana F., Beckmann, Richard P.
Published in Molecular cancer research (01.11.2016)
Published in Molecular cancer research (01.11.2016)
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Journal Article
Studies on cyclin-dependent kinase inhibitors: Indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
SANCHEZ-MARTINEZ, Concha, CHUAN SHIH, OGG, Catherine A, CONSIDINE, Eileen, DEMPSEY, Jack A, FAMING ZHANG, GUOXIN ZHU, TIECHAO LI, BROOKS, Harold B, PATEL, Bharvin K. R, SCHULTZ, Richard M, DEHAHN, Tammy B, SPENCER, Charles D, WATKINS, Scott A
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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