MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition
Fell, Matthew J, Mirescu, Christian, Basu, Kallol, Cheewatrakoolpong, Boonlert, DeMong, Duane E, Ellis, J Michael, Hyde, Lynn A, Lin, Yinghui, Markgraf, Carrie G, Mei, Hong, Miller, Michael, Poulet, Frederique M, Scott, Jack D, Smith, Michelle D, Yin, Zhizhang, Zhou, Xiaoping, Parker, Eric M, Kennedy, Matthew E, Morrow, John A
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
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Journal Article
Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease
Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
A Novel Method for the Preparation of 4‑Arylimidazolones
DeMong, Duane E, Ng, Irene, Miller, Michael W, Stamford, Andrew W
Published in Organic letters (07.06.2013)
Published in Organic letters (07.06.2013)
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Journal Article
Asymmetric Synthesis of (2S,3R)-Capreomycidine and the Total Synthesis of Capreomycin IB
DeMong, Duane E, Williams, Robert M
Published in Journal of the American Chemical Society (16.07.2003)
Published in Journal of the American Chemical Society (16.07.2003)
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Journal Article
Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs
Chen, Helen Y., Plummer, Christopher W., Xiao, Dong, Chobanian, Harry R., DeMong, Duane, Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Souza, Sarah, Tatosian, Daniel A., Chen, Qing, Hafey, Michael J., Houle, Robert, Nolting, Andrew F., Orr, Robert, Ehrhart, Juliann, Weinglass, Adam B., Tschirret-Guth, Richard, Howard, Andrew D., Colletti, Steven L.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Journal Article
Synthesis, Structure−Activity Relationship and in Vivo Antiinflammatory Efficacy of Substituted Dipiperidines as CCR2 Antagonists
Xia, Mingde, Hou, Cuifen, DeMong, Duane E, Pollack, Scott R, Pan, Meng, Brackley, James A, Jain, Nareshkumar, Gerchak, Chrissy, Singer, Monica, Malaviya, Ravi, Matheis, Michele, Olini, Gil, Cavender, Druie, Wachter, Michael
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Journal Article
Asymmetric Synthesis of (+)-Hypusine
Jain, Rajendra P, Albrecht, Brian K, DeMong, Duane E, Williams, Robert M
Published in Organic letters (27.12.2001)
Published in Organic letters (27.12.2001)
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Journal Article
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins
Fryszkowska, Anna, An, Chihui, Alvizo, Oscar, Banerjee, Goutami, Canada, Keith A., Cao, Yang, DeMong, Duane, Devine, Paul N., Duan, Da, Elgart, David M., Farasat, Iman, Gauthier, Donald R., Guidry, Erin N., Jia, Xiujuan, Kong, Jongrock, Kruse, Nikki, Lexa, Katrina W., Makarov, Alexey A., Mann, Benjamin F., Milczek, Erika M., Mitchell, Vesna, Nazor, Jovana, Neri, Claudia, Orr, Robert K., Orth, Peter, Phillips, Eric M., Riggins, James N., Schafer, Wes A., Silverman, Steven M., Strulson, Christopher A., Subramanian, Nandhitha, Voladri, Rama, Yang, Hao, Yang, Jie, Yi, Xiang, Zhang, Xiyun, Zhong, Wendy
Published in Science (American Association for the Advancement of Science) (17.06.2022)
Published in Science (American Association for the Advancement of Science) (17.06.2022)
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Journal Article
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
ChemInform Abstract: A Novel Method for the Preparation of 4-Arylimidazolones
DeMong, Duane E., Ng, Irene, Miller, Michael W., Stamford, Andrew W.
Published in ChemInform (01.10.2013)
Published in ChemInform (01.10.2013)
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Journal Article
Abstract PR017: Discovery and clinical evaluation of a potent and selective A2A/2B dual receptor antagonist
DeMong, Duane, Ranganath, Sheila, Cumming, Jared, Larsen, Matthew, Zhang, Yonglian, Plummer, Christopher, Ali, Amjad, Palmieri, Anthony, Barry, Evan, Daublain, Pierre, Gupta, Pranav, Chatterjee, Manash, Giranda, Vincent, Presland, Jeremy, Schneider, Sebastian, Ciaccio, Paul, Tatosian, Daniel, Sather, Aaron, Turnbull, Ben, Silverman, Steven, Chobanian, Harry, Krishnamurthy, Harini, Wnek, Richard, Afshar, Roshi, Crowley, Stephen, Miller, Alita, Ayers, Mark, Whitehead, Alan, Hinton, Marlene, Chiang, Derek, Orr, Robert, Chrencik, Jill
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
mGluR2-음성 알로스테릭 조정제로서의 크로만, 이소크로만 및 디히드로이소벤조푸란 유도체, 조성물, 및 그의 용도
ARASAPPAN ASHOK, HOYT SCOTT B, SEBHAT IYASSU K, DEMONG DUANE, WILKENING ROBERT R
Year of Publication 24.05.2019
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Year of Publication 24.05.2019
Patent
The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist
DeMong, Duane, Dai, Xing, Hwa, Joyce, Miller, Michael, Lin, Sue-Ing, Kang, Ling, Stamford, Andrew, Greenlee, William, Yu, Wensheng, Wong, Michael, Lavey, Brian, Kozlowski, Joseph, Zhou, Guowei, Yang, De-Yi, Patel, Bhuneshwari, Soriano, Aileen, Zhai, Ying, Sondey, Christopher, Zhang, Hongtao, Lachowicz, Jean, Grotz, Diane, Cox, Kathleen, Morrison, Richard, Andreani, Teresa, Cao, Yang, Liang, Mark, Meng, Tao, McNamara, Paul, Wong, Jesse, Bradley, Prudence, Feng, Kung-I, Belani, Jitendra, Chen, Ping, Dai, Peng, Gauuan, Jolicia, Lin, Peishan, Zhao, He
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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아데노신 수용체 길항제로서의 7-, 8- 및 10-치환된 아미노 트리아졸로 퀴나졸린 유도체, 제약 조성물 및 그의 용도
WANG HUIJUN, SWAMINATHAN UMA, ALI AMJAD, LARSEN MATTHEW A, LIU PING, PAN JIANPING, DENG QIAOLIN, MANSOOR UMAR FARUK, LIU KUN, CUMMING JARED, DEMONG DUANE, ZHANG YONGLIAN, PLUMMER CHRISTOPHER W, SATHER AARON, GRAHAM THOMAS H, HENNESSY ELISABETH
Year of Publication 06.08.2021
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Year of Publication 06.08.2021
Patent
아데노신 수용체 길항제로서의 9-치환된 아미노 트리아졸로 퀴나졸린 유도체, 제약 조성물 및 그의 용도
WANG HUIJUN, SWAMINATHAN UMA, ALI AMJAD, LARSEN MATTHEW A, LIU PING, PAN JIANPING, DENG QIAOLIN, MANSOOR UMAR FARUK, LIU KUN, CUMMING JARED, DEMONG DUANE, PLUMMER CHRISTOPHER W, SATHER AARON, ZHANG YONGLIAN, GRAHAM THOMAS H, HOOVER ANDREW J, HENNESSY ELISABETH
Year of Publication 04.08.2021
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Year of Publication 04.08.2021
Patent
치환된 아미노 트리아졸로피리미딘 및 아미노 트리아졸로피라진 아데노신 수용체 길항제, 제약 조성물 및 그의 용도
WANG HUIJUN, ALI AMJAD, DENG QIAOLIN, CUMMING JARED, KUANG RONGZE, DEMONG DUANE, RICO DUQUE JENNY LORENA, BRILL ZACHARY G, PLUMMER CHRISTOPHER W, ZHANG YONGLIAN, GRAHAM THOMAS H, LIM YEON HEE, ZHAO KAKE
Year of Publication 28.07.2021
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Year of Publication 28.07.2021
Patent
STING 효능제로서의 벤조티오펜 및 관련 화합물
CASH BRANDON D, CUMMING JARED N, JEWELL JAMES P, LARSEN MATTHEW A, DEMONG DUANE E, ALTMAN MICHAEL D, LIM JONGWON, HENDERSON TIMOTHY J, LU MIN, CHILDERS MATTHEW LLOYD, OTTE RYAN D, HAIDLE ANDREW MARC, TROTTER BENJAMIN WESLEY
Year of Publication 11.12.2020
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Year of Publication 11.12.2020
Patent