Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350
Raboisson, Pierre, de Kock, Herman, Rosenquist, Åsa, Nilsson, Magnus, Salvador-Oden, Lourdes, Lin, Tse-I, Roue, Natalie, Ivanov, Vladimir, Wähling, Horst, Wickström, Kristina, Hamelink, Elizabeth, Edlund, Michael, Vrang, Lotta, Vendeville, Sandrine, Van de Vreken, Wim, McGowan, David, Tahri, Abdellah, Hu, Lili, Boutton, Carlo, Lenz, Oliver, Delouvroy, Frederic, Pille, Geert, Surleraux, Dominique, Wigerinck, Piet, Samuelsson, Bertil, Simmen, Kenneth
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor
LIN, Tse-I, LENZ, Oliver, VRANG, Lotta, DE KOCK, Herman, WIGERINCK, Piet, RABOISSON, Pierre, SIMMEN, Kenneth, FANNING, Gregory, VERBINNEN, Thierry, DELOUVROY, Frédéric, SCHOLLIERS, Annick, VERMEIREN, Katrien, ROSENQUIST, Asa, EDLUND, Michael, SAMUELSSON, Bertil
Published in Antimicrobial Agents and Chemotherapy (01.04.2009)
Published in Antimicrobial Agents and Chemotherapy (01.04.2009)
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Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors
Raboisson, Pierre, Lenz, Oliver, Lin, Tse-I, Surleraux, Dominique, Chakravarty, Sarvajit, Scholliers, Annick, Vermeiren, Katrien, Delouvroy, Frederic, Verbinnen, Thierry, Simmen, Kenneth
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors
NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
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1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus
NYANGUILE, Origène, DEVOGELAERE, Benoit, VANDERCRUYSSEN, Geneviève, VERMEIREN, Katrien, MOSTMANS, Wendy, DEHERTOGH, Pascale, DELOUVROY, Frédéric, VENDEVILLE, Sandrine, VANDYCK, Koen, DOCKX, Koen, CLEIREN, Ema, RABOISSON, Pierre, VIJGEN, Leen, SIMMEN, Kenneth A, FANNING, Gregory C, VAN DEN BROECK, Walter, PAUWELS, Frederik, CUMMINGS, Maxwell D, DE BONDT, Hendrik L, VOS, Ann M, BERKE, Jan M, LENZ, Oliver
Published in Journal of Virology (01.03.2010)
Published in Journal of Virology (01.03.2010)
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Synthesis and evaluation of novel HCV replication inhibitors
McGowan, David C., Khamlichi, Mourad D., De Groot, Alex, Pauwels, Frederik, Delouvroy, Frédéric, Van Emelen, Kristof, Simmen, Kenneth, Raboisson, Pierre
Published in Molecular diversity (01.05.2017)
Published in Molecular diversity (01.05.2017)
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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase
McGowan, David, Nyanguile, Origène, Cummings, Maxwell D., Vendeville, Sandrine, Vandyck, Koen, Van den Broeck, Walter, Boutton, Carlo W., De Bondt, Hendrik, Quirynen, Ludo, Amssoms, Katie, Bonfanti, Jean-François, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Hu, Lili, Delouvroy, Frédéric, Vermeiren, Katrien, Vandercruyssen, Geneviève, Van der Helm, Liesbet, Cleiren, Erna, Mostmans, Wendy, Lory, Pedro, Pille, Geert, Van Emelen, Kristof, Fanning, Gregory, Pauwels, Frederik, Lin, Tse-I, Simmen, Kenneth, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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ambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process performance to product quality attributes
Delouvroy, Frédéric, Siriez, Gaetan, Tran, An-Vy, Mukankurayija, Larissa, Kochanowski, Nadine, Malphettes, Laetitia
Published in BMC proceedings (14.12.2015)
Published in BMC proceedings (14.12.2015)
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Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors
Raboisson, Pierre, Lin, Tse-I, Kock, Herman de, Vendeville, Sandrine, Vreken, Wim Van de, McGowan, David, Tahri, Abdellah, Hu, Lili, Lenz, Oliver, Delouvroy, Frederic, Surleraux, Dominique, Wigerinck, Piet, Nilsson, Magnus, Rosenquist, Åsa, Samuelsson, Bertil, Simmen, Kenneth
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors
VENDEVILLE, Sandrine, NILSSON, Magnus, ENEROTH, Anders, WIKSTROM, Kristina, VRANG, Lotta, EDLUND, Michael, LINDSTRÖM, Stefan, VAN DE VREKEN, Wim, MCGOWAN, David, TAHRI, Abdellah, LILI HU, LENZ, Oliver, DE KOCK, Herman, DELOUVROY, Frederic, VAN DOOREN, Marleen, KINDERMANS, Natalie, SURLERAUX, Dominique, WIGERINCK, Piet, ROSENQUIST, Asa, SAMUELSSON, Bertil, SIMMENA, Kenneth, RABOISSON, Pierre, LINA, Tse-I, ANTONOV, Dmitry, CLASSON, Björn, AYESA, Susana, IVANOV, Vladimir, JOHANSSON, Per-Ola, KAHNBERG, Pia
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Evaluation of the advanced micro-scale bioreactor (ambr™) as a highthroughput tool for cell culture process development
Delouvroy, Frédéric, Le Reverend, Guillaume, Fessler, Boris, Mathy, Gregory, Harmsen, Mareike, Kochanowski, Nadine, Malphettes, Laetitia
Published in BMC proceedings (04.12.2013)
Published in BMC proceedings (04.12.2013)
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