Epigenetic programming underpins B cell dysfunction in human SLE
Scharer, Christopher D., Blalock, Emily L., Mi, Tian, Barwick, Benjamin G., Jenks, Scott A., Deguchi, Tsuneo, Cashman, Kevin S., Neary, Bridget E., Patterson, Dillon G., Hicks, Sakeenah L., Khosroshahi, Arezou, Eun-Hyung Lee, F., Wei, Chungwen, Sanz, Iñaki, Boss, Jeremy M.
Published in Nature immunology (01.08.2019)
Published in Nature immunology (01.08.2019)
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Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
Kazuki, Yasuhiro, Kobayashi, Kaoru, Hirabayashi, Masumi, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Takiguchi, Masato, Satoh, Daisuke, Kuze, Jiro, Sakuma, Tetsushi, Kaneko, Takehito, Mashimo, Tomoji, Osamura, Minori, Hashimoto, Mari, Wakatsuki, Riko, Hirashima, Rika, Fujiwara, Ryoichi, Deguchi, Tsuneo, Kurihara, Atsushi, Tsukazaki, Yasuko, Senda, Naoto, Yamamoto, Takashi, Scheer, Nico, Oshimura, Mitsuo
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2019)
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The Comprehensive Characterization of B7-H3 Expression in the Tumor Microenvironment of Lung Squamous Cell Carcinoma: A Retrospective Study
Asakawa, Ayaka, Yoshimoto, Ryoto, Kobayashi, Maki, Izumi, Nanae, Maejima, Takanori, Deguchi, Tsuneo, Kubota, Kazuishi, Takahashi, Hisashi, Yamada, Miyuki, Ishibashi, Sachiko, Onishi, Iichiroh, Kinowaki, Yuko, Kurata, Morito, Kobayashi, Masashi, Ishibashi, Hironori, Okubo, Kenichi, Ohashi, Kenichi, Kitagawa, Masanobu, Yamamoto, Kouhei
Published in Cancers (01.06.2024)
Published in Cancers (01.06.2024)
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Characterization of uremic toxin transport by organic anion transporters in the kidney
Deguchi, Tsuneo, Kusuhara, Hiroyuki, Takadate, Akira, Endou, Hitoshi, Otagiri, Masaki, Sugiyama, Yuichi
Published in Kidney international (01.01.2004)
Published in Kidney international (01.01.2004)
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Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes
Kobayashi, Kaoru, Deguchi, Tsuneo, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Nakamura, Kazuomi, Kurihara, Atsushi, Oshimura, Mitsuo, Kazuki, Yasuhiro
Published in Pharmacology research & perspectives (01.12.2022)
Published in Pharmacology research & perspectives (01.12.2022)
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In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions
Makino, Chie, Watanabe, Akiko, Deguchi, Tsuneo, Shiozawa, Hideyuki, Schreck, Ilona, Rozehnal, Veronika, Ishizuka, Tomoko, Watanabe, Nobuaki, Ando, Osamu, Murayama, Norie, Yamazaki, Hiroshi
Published in Xenobiotica (03.08.2019)
Published in Xenobiotica (03.08.2019)
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Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain
Ohtsuki, Sumio, Asaba, Hiroshi, Takanaga, Hitomi, Deguchi, Tsuneo, Hosoya, Ken‐ichi, Otagiri, Masaki, Terasaki, Tetsuya
Published in Journal of neurochemistry (01.10.2002)
Published in Journal of neurochemistry (01.10.2002)
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Rat Organic Anion Transporter 3 (rOAT3) Is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial Cells
Mori, Shinobu, Takanaga, Hitomi, Ohtsuki, Sumio, Deguchi, Tsuneo, Kang, Young-Sook, Hosoya, Ken-ichi, Terasaki, Tetsuya
Published in Journal of cerebral blood flow and metabolism (01.04.2003)
Published in Journal of cerebral blood flow and metabolism (01.04.2003)
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Journal Article
Renal Clearance of Endogenous Hippurate Correlates with Expression Levels of Renal Organic Anion Transporters in Uremic Rats
Deguchi, Tsuneo, Takemoto, Mizue, Uehara, Nao, Lindup, W Edward, Suenaga, Ayaka, Otagiri, Masaki
Published in The Journal of pharmacology and experimental therapeutics (01.08.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2005)
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Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation
Uto, Yoshikazu, Ogata, Tsuneaki, Kiyotsuka, Yohei, Miyazawa, Yuriko, Ueno, Yuko, Kurata, Hitoshi, Deguchi, Tsuneo, Yamada, Makiko, Watanabe, Nobuaki, Takagi, Toshiyuki, Wakimoto, Satoko, Okuyama, Ryo, Konishi, Masahiro, Kurikawa, Nobuya, Kono, Keita, Osumi, Jun
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
Uto, Yoshikazu, Ogata, Tsuneaki, Harada, Jun, Kiyotsuka, Yohei, Ueno, Yuko, Miyazawa, Yuriko, Kurata, Hitoshi, Deguchi, Tsuneo, Watanabe, Nobuaki, Takagi, Toshiyuki, Wakimoto, Satoko, Okuyama, Ryo, Abe, Manabu, Kurikawa, Nobuya, Kawamura, Sayako, Yamato, Michiko, Osumi, Jun
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Renal Disposition of a Furan Dicarboxylic Acid and Other Uremic Toxins in the Rat
Tsutsumi, Yasuhiro, Deguchi, Tsuneo, Takano, Mikihisa, Takadate, Akira, Lindup, W Edward, Otagiri, Masaki
Published in The Journal of pharmacology and experimental therapeutics (01.11.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2002)
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BUCOLOME, A POTENT BINDING INHIBITOR FOR FUROSEMIDE, ALTERS THE PHARMACOKINETICS AND DIURETIC EFFECT OF FUROSEMIDE: POTENTIAL FOR USE OF BUCOLOME TO RESTORE DIURETIC RESPONSE IN NEPHROTIC SYNDROME
TAKAMURA, Norito, MARUYAMA, Toru, CHOSA, Etsuo, KAWAI, Keiichi, TSUTSUMI, Yasuhiro, URYU, Yukie, YAMASAKI, Keishi, DEGUCHI, Tsuneo, OTAGIRI, Masaki
Published in Drug metabolism and disposition (01.04.2005)
Published in Drug metabolism and disposition (01.04.2005)
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Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells
MORI, Shinobu, TAKANAGA, Hitomi, OHTSUKI, Sumio, DEGUCHI, Tsuneo, KANG, Young-Sook, HOSOYA, Ken-Ichi, TERASAKI, Tetsuya
Published in Journal of cerebral blood flow and metabolism (01.04.2003)
Published in Journal of cerebral blood flow and metabolism (01.04.2003)
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Journal Article
Epigenetic programming underpins B cell dysfunction in human SLE
Scharer, Christopher, Blalock, Emily, Mi, Tian, Barwick, Benjamin, Jenks, Scott, Neary, Bridget, Patterson, Dillon, Deguchi, Tsuneo, Lee, Eun-Hyung, Wei, Chungwen, Sanz, Ignacio, Boss, Jeremy M
Published in The Journal of immunology (1950) (01.05.2019)
Published in The Journal of immunology (1950) (01.05.2019)
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The Baseline Gut Microbiota Enterotype Directs Lifestyle-Induced Amelioration of Pollen Allergy Severity: A Self Controlled Case-Series Study
Watanabe, Satoshi, Fukushima, Takayoshi, Matsuo, Yusuke, Morimoto, Takahito, Deguchi, Tsuneo, Fukumuro, Keisuke, Sawai, Yu
Published in Applied Microbiology (Basel) (10.11.2022)
Published in Applied Microbiology (Basel) (10.11.2022)
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