Refining Hepatocyte Models to Capture the Impact of CYP2D610 Utilizing a PITCh System
Negoro, Ryosuke, Ouchi, Ayu, Deguchi, Sayaka, Takayama, Kazuo, Fujita, Takuya
Published in Biological & pharmaceutical bulletin (08.08.2024)
Published in Biological & pharmaceutical bulletin (08.08.2024)
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Journal Article
Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells
Hashimoto, Rina, Sakamoto, Ayaka, Deguchi, Sayaka, Yi, Renxing, Sano, Emi, Hotta, Akitsu, Takahashi, Kazutoshi, Yamanaka, Shinya, Takayama, Kazuo
Published in Molecular therapy. Nucleic acids (03.12.2021)
Published in Molecular therapy. Nucleic acids (03.12.2021)
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Journal Article
Application of perfluoropolyether elastomers in microfluidic drug metabolism assays
Wang, Mengyang, Tsuda, Masahiro, Deguchi, Sayaka, Higuchi, Yuriko, So, Kanako, Torisawa, Yu-suke, Takayama, Kazuo, Yamashita, Fumiyoshi
Published in International journal of pharmaceutics (05.11.2022)
Published in International journal of pharmaceutics (05.11.2022)
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Journal Article
Establishment of MDR1-knockout human induced pluripotent stem cell line
Negoro, Ryosuke, Kawai, Kanae, Ichikawa, Moe, Deguchi, Sayaka, Takayama, Kazuo, Mizuguchi, Hiroyuki
Published in Drug metabolism and pharmacokinetics (01.06.2020)
Published in Drug metabolism and pharmacokinetics (01.06.2020)
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Journal Article
Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells
Deguchi, Sayaka, Yamashita, Tomoki, Igai, Keisuke, Harada, Kazuo, Toba, Yukiko, Hirata, Kazumasa, Takayama, Kazuo, Mizuguchi, Hiroyuki
Published in Drug metabolism and disposition (01.06.2019)
Published in Drug metabolism and disposition (01.06.2019)
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Journal Article
Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells
Hashimoto, Rina, Sakamoto, Ayaka, Deguchi, Sayaka, Yi, Renxing, Sano, Emi, Hotta, Akitsu, Takahashi, Kazutoshi, Yamanaka, Shinya, Takayama, Kazuo
Published in Molecular therapy. Nucleic acids (01.12.2021)
Published in Molecular therapy. Nucleic acids (01.12.2021)
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Journal Article
SARS‐CoV‐2 research using human pluripotent stem cells and organoids
Deguchi, Sayaka, Serrano‐Aroca, Ángel, Tambuwala, Murtaza M., Uhal, Bruce D., Brufsky, Adam M., Takayama, Kazuo
Published in Stem cells translational medicine (01.11.2021)
Published in Stem cells translational medicine (01.11.2021)
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Journal Article
Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes
Deguchi, Sayaka, Tsuda, Masahiro, Kosugi, Kaori, Sakamoto, Ayaka, Mimura, Natsumi, Negoro, Ryosuke, Sano, Emi, Nobe, Takuro, Maeda, Kazuya, Kusuhara, Hiroyuki, Mizuguchi, Hiroyuki, Yamashita, Fumiyoshi, Torisawa, Yu-suke, Takayama, Kazuo
Published in ACS biomaterials science & engineering (09.08.2021)
Published in ACS biomaterials science & engineering (09.08.2021)
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Journal Article
Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies
Kawai, Kanae, Negoro, Ryosuke, Ichikawa, Moe, Yamashita, Tomoki, Deguchi, Sayaka, Harada, Kazuo, Hirata, Kazumasa, Takayama, Kazuo, Mizuguchi, Hiroyuki
Published in Molecular therapy. Methods & clinical development (12.06.2020)
Published in Molecular therapy. Methods & clinical development (12.06.2020)
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Journal Article
In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology
Deguchi, Sayaka, Shintani, Tomohiro, Harada, Kazuo, Okamoto, Toru, Takemura, Akinori, Hirata, Kazumasa, Ito, Kousei, Takayama, Kazuo, Mizuguchi, Hiroyuki
Published in Hepatology communications (01.08.2021)
Published in Hepatology communications (01.08.2021)
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Journal Article
Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips
Deguchi, Sayaka, Kosugi, Kaori, Hashimoto, Rina, Sakamoto, Ayaka, Yamamoto, Masaki, Krol, Rafal P, Gee, Peter, Negoro, Ryosuke, Noda, Takeshi, Yamamoto, Takuya, Torisawa, Yu-Suke, Nagao, Miki, Takayama, Kazuo
Published in PNAS nexus (01.03.2023)
Published in PNAS nexus (01.03.2023)
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Journal Article
Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells
Sano, Emi, Deguchi, Sayaka, Sakamoto, Ayaka, Mimura, Natsumi, Hirabayashi, Ai, Muramoto, Yukiko, Noda, Takeshi, Yamamoto, Takuya, Takayama, Kazuo
Published in iScience (21.05.2021)
Published in iScience (21.05.2021)
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Journal Article
Tolloid‐Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling
Kiso, Ayumi, Toba, Yukiko, Tsutsumi, Susumu, Deguchi, Sayaka, Igai, Keisuke, Koshino, Saki, Tanaka, Yasuhito, Takayama, Kazuo, Mizuguchi, Hiroyuki
Published in Hepatology communications (01.02.2020)
Published in Hepatology communications (01.02.2020)
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Journal Article
Generation of Tetrafluoroethylene–Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies
Sano, Emi, Deguchi, Sayaka, Matsuoka, Naoki, Tsuda, Masahiro, Wang, Mengyang, Kosugi, Kaori, Mori, Chihiro, Yagi, Keisuke, Wada, Aya, Yamasaki, Shinsuke, Kawai, Tsuyoshi, Yodogawa, Masahide, Mizuguchi, Hiroyuki, Nakazawa, Norihito, Yamashita, Fumiyoshi, Torisawa, Yu-suke, Takayama, Kazuo
Published in ACS omega (28.09.2021)
Published in ACS omega (28.09.2021)
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Journal Article
Organ-on-a-chip models for elucidating the cellular biology of infectious diseases
Yokoi, Fuki, Deguchi, Sayaka, Takayama, Kazuo
Published in Biochimica et biophysica acta. Molecular cell research (01.08.2023)
Published in Biochimica et biophysica acta. Molecular cell research (01.08.2023)
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Journal Article