Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection
DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
Get full text
Journal Article
Antiviral Drug Discovery for the Treatment of COVID-19 Infections
Ng, Teresa I, Correia, Ivan, Seagal, Jane, DeGoey, David A, Schrimpf, Michael R, Hardee, David J, Noey, Elizabeth L, Kati, Warren M
Published in Viruses (04.05.2022)
Published in Viruses (04.05.2022)
Get full text
Journal Article
Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A
DeGoey, David A., Randolph, John T., Liu, Dachun, Pratt, John, Hutchins, Charles, Donner, Pamela, Krueger, A. Chris, Matulenko, Mark, Patel, Sachin, Motter, Christopher E., Nelson, Lissa, Keddy, Ryan, Tufano, Michael, Caspi, Daniel D., Krishnan, Preethi, Mistry, Neeta, Koev, Gennadiy, Reisch, Thomas J., Mondal, Rubina, Pilot-Matias, Tami, Gao, Yi, Beno, David W. A., Maring, Clarence J., Molla, Akhter, Dumas, Emily, Campbell, Andrew, Williams, Laura, Collins, Christine, Wagner, Rolf, Kati, Warren M.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Development of a sensitive high-throughput enzymatic assay capable of measuring sub-nanomolar inhibitors of SARS-CoV2 Mpro
Kovar, Peter, Richardson, Paul L, Korepanova, Alla, Afanador, Gustavo A, Stojkovic, Vladimir, Li, Tao, Schrimpf, Michael R, Ng, Teresa I, Degoey, David A, Gopalakrishnan, Sujatha M, Chen, Jun
Published in SLAS discovery (01.09.2024)
Published in SLAS discovery (01.09.2024)
Get full text
Journal Article
Implications of the Conformationally Flexible, Macrocyclic Structure of the First-Generation, Direct-Acting Anti-Viral Paritaprevir on Its Solid Form Complexity and Chameleonic Behavior
Sheikh, Ahmad Y., Mattei, Alessandra, Miglani Bhardwaj, Rajni, Hong, Richard S., Abraham, Nathan S., Schneider-Rauber, Gabriela, Engstrom, Kenneth M., Diwan, Moiz, Henry, Rodger F., Gao, Yi, Juarez, Vivian, Jordan, Erin, DeGoey, David A., Hutchins, Charles W.
Published in Journal of the American Chemical Society (27.10.2021)
Published in Journal of the American Chemical Society (27.10.2021)
Get full text
Journal Article
Enantioselective Synthesis of Antiinfluenza Compound A-315675
DeGoey, David A, Chen, Hui-Ju, Flosi, William J, Grampovnik, David J, Yeung, Clinton M, Klein, Larry L, Kempf, Dale J
Published in Journal of organic chemistry (09.08.2002)
Published in Journal of organic chemistry (09.08.2002)
Get full text
Journal Article
Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530)
Randolph, John T, Voight, Eric A, Greszler, Stephen N, Uno, Brice E, Newton, James N, Gleason, Kenneth M, Stolarik, DeAnne, Van Handel, Cecilia, Bow, Daniel A. J, DeGoey, David A
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
Get full text
Journal Article
Desymmetrization of pibrentasvir for efficient prodrug synthesis
Voight, Eric A, Greszler, Stephen N, Hartung, John, Ji, Jianguo, Klix, Russell C, Randolph, John T, Shelat, Bhadra H, Waters, Jan E, DeGoey, David A
Published in Chemical science (Cambridge) (28.07.2021)
Published in Chemical science (Cambridge) (28.07.2021)
Get full text
Journal Article
Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection: Miniperspective
DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
Get full text
Journal Article
Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742
Dekhtyar, Tatyana, Ng, Teresa I, Lu, Liangjun, Masse, Sherie, DeGoey, David A, Flosi, William J, Grampovnik, David J, Klein, Larry L, Kempf, Dale J, Molla, Akhteruzzaman
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Get full text
Journal Article
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain
Patel, Meena V., Peltier, Hillary M., Matulenko, Mark A., Koenig, John R., C. Scanio, Marc J., Gum, Rebecca J., El-Kouhen, Odile F., Fricano, Meagan M., Lundgaard, Greta L., Neelands, Torben, Zhang, Xu-Feng, Zhan, Cenchen, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Hudzik, Thomas, Gintant, Gary, Martin, Ruth, McGaraughty, Steve, Xu, Jun, Bow, Daniel, Kalvass, John C., Kym, Philip R., DeGoey, David A., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (01.06.2022)
Published in Bioorganic & medicinal chemistry (01.06.2022)
Get full text
Journal Article
Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors
Randolph, John T., Li, Tongmei, Chris Krueger, A., Heyman, Howard R., Chen, Hui-Ju, Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle, Krishnan, Preethi, Wagner, Rolf, DeGoey, David A.
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
Get full text
Journal Article
Synthesis and evaluation of 2′-dihalo ribonucleotide prodrugs with activity against hepatitis C virus
Chris Krueger, A., Chen, Hui-Ju, Randolph, John T., Brown, Brian S., Halvorsen, Geoff T., Heyman, Howard R., Li, Tongmei, Marvin, Christopher C., Shanley, Jason P., Voight, Eric A., Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle L., Krishnan, Preethi, Henry, Rodger F., Wagner, Rolf, DeGoey, David A.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
Get full text
Journal Article
Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A
DeGoey, David A., Betebenner, David A., Grampovnik, David J., Liu, Dachun, Pratt, John K., Tufano, Michael D., He, Wenping, Krishnan, Preethi, Pilot-Matias, Tami J., Marsh, Kennan C., Molla, Akhteruzzaman, Kempf, Dale J., Maring, Clarence J.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Get full text
Journal Article
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
Frost, Jennifer M, DeGoey, David A, Shi, Lei, Gum, Rebecca J, Fricano, Meagan M, Lundgaard, Greta L, El-Kouhen, Odile F, Hsieh, Gin C, Neelands, Torben, Matulenko, Mark A, Daanen, Jerome F, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Zhan, Cenchen, Zhang, Xu-Feng, Kort, Michael E
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
Get full text
Journal Article
Practical Preclinical Model for Assessing the Potential for Unconjugated Hyperbilirubinemia Produced by Human Immunodeficiency Virus Protease Inhibitors
KEMPF, Dale J, WARING, Jeffrey F, MARSH, Kennan, MORFITT, David C, WERNER, Paige, EBERT, Brian, MITTEN, Michael, NGUYEN, Bach, RANDOLPH, John T, DEGOEY, David A, KLEIN, Larry L
Published in Antimicrobial Agents and Chemotherapy (01.02.2006)
Published in Antimicrobial Agents and Chemotherapy (01.02.2006)
Get full text
Journal Article
Water-Soluble Prodrugs of the Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir
DeGoey, David A, Grampovnik, David J, Flosi, William J, Marsh, Kennan C, Wang, Xiu C, Klein, Larry L, McDaniel, Keith F, Liu, Yaya, Long, Michelle A, Kati, Warren M, Molla, Akhteruzzaman, Kempf, Dale J
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
Get full text
Journal Article
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Krueger, A. Chris, Randolph, John T., DeGoey, David A., Donner, Pamela L., Flentge, Charles A., Hutchinson, Douglas K., Liu, Dachun, Motter, Christopher E., Rockway, Todd W., Wagner, Rolf, Beno, David W.A., Koev, Gennadiy, Lim, Hock B., Beyer, Jill M., Mondal, Rubina, Liu, Yaya, Kati, Warren M., Longenecker, Kenton L., Molla, Akhteruzzaman, Stewart, Kent D., Maring, Clarence J.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Get full text
Journal Article
P1-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors with Potent Antiviral Activity against Drug-Resistant Viruses
DeGoey, David A, Grampovnik, David J, Chen, Hui-Ju, Flosi, William J, Klein, Larry L, Dekhtyar, Tatyana, Stoll, Vincent, Mamo, Mulugeta, Molla, Akhteruzzaman, Kempf, Dale J
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
Get full text
Journal Article