Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Journal Article
브루톤 티로신 키나제 억제제 및 이의 사용 방법
CHEN WEI, XIAO KUN, TICHENOR MARK S, ARORA NIDHI, ZHANG FEIHUANG, WEI JIANMEI, KREUTTER KEVIN, WIENER JOHN J. M, EDWARDS JAMES P, ZHANG ZHENG, BACANI GENESIS M, CAI MIN, DECKHUT CHARLOTTE POOLEY, VENABLE JENNIFER D, ZHU YAOPING, BEMBENEK SCOTT D, GHOSH BRAHMANANDA, WU YAO, BARBAY JOSEPH KENT, LI GANG, HAO BAOYU
Year of Publication 23.08.2018
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Year of Publication 23.08.2018
Patent
브루톤 티로신 키나제의 억제제로서의 폴리사이클릭 화합물
CHEN WEI, XIAO KUN, TICHENOR MARK S, ARORA NIDHI, ZHANG FEIHUANG, WEI JIANMEI, KREUTTER KEVIN, WIENER JOHN J. M, EDWARDS JAMES P, BACANI GENESIS M, CAI MIN, DECKHUT CHARLOTTE POOLEY, VENABLE JENNIFER D, ZHU YAOPING, BEMBENEK SCOTT D, GHOSH BRAHMANANDA, WU YAO, BARBAY JOSEPH KENT, LI GANG
Year of Publication 22.08.2018
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Year of Publication 22.08.2018
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Inhibitors of Bruton's tyrosine kinase and method of their use
Bembenek, Scott D, Kreutter, Kevin D, Wiener, John J. M, Bacani, Genesis M, Arora, Nidhi, Ghosh, Brahmananda, Tichenor, Mark S, Edwards, James P, Barbay, Joseph Kent, Deckhut, Charlotte Pooley, Wei, Jianmei, Venable, Jennifer D
Year of Publication 20.08.2024
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Year of Publication 20.08.2024
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BENZIMIDAZOLES AS MODULATORS OF IL-17
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Year of Publication 07.08.2024
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Year of Publication 07.08.2024
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INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE
Bembenek, Scott D, ARORA, Nidhi, Kreutter, Kevin D, Bacani, Genesis M, Wiener, John J.M, Ghosh, Brahmananda, Tichenor, Mark S, Edwards, James P, Barbay, Joseph Kent, Deckhut, Charlotte Pooley, Wei, Jianmei, Venable, Jennifer D
Year of Publication 30.03.2023
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Year of Publication 30.03.2023
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BENZIMIDAZOLES AS MODULATORS OF IL-17
KEITH, JOHN, WOODS, CRAIG R, BEHENNA, DOUGLAS C, TANIS, VIRGINIA M, JACKSON, PAUL F, DECKHUT, CHARLOTTE POOLEY, MARTIN, CONNOR, MEDUNA, STEVEN P, BEMBENEK, SCOTT, RHORER, TIMOTHY B, MCCARVER, STEFAN, SHIH, AMY Y, XUE, XIAOHUA, LOSKOT, STEVEN A, GOLDBERG, STEVEN D
Year of Publication 30.03.2023
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Year of Publication 30.03.2023
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INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
VENABLE, JENNIFER D, WU, YAO, ZHANG, FEIHUANG, CAI, MIN, BEMBENEK, SCOTT D, XIAO, KUN, ZHU, YAOPING, EDWARDS, JAMES P, BACANI, GENESIS M, DECKHUT, CHARLOTTE POOLEY, WEI, JIANMEI, LI, GANG, TICHENOR, MARK S, WIENER, JOHN J. M, HAO, BAOYU, ZHANG, ZHENG, GHOSH, BRAHMANANDA, ARORA, NIDHI, KREUTTER, KEVIN D, CHEN, WEI, BARBAY, JOSEPH KENT
Year of Publication 16.01.2024
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Year of Publication 16.01.2024
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POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE
VENABLE, JENNIFER D, WU, YAO, ZHANG, FEIHUANG, CAI, MIN, BEMBENEK, SCOTT D, XIAO, KUN, ZHU, YAOPING, EDWARDS, JAMES P, BACANI, GENESIS M, DECKHUT, CHARLOTTE POOLEY, WEI, JIANMEI, LI, GANG, TICHENOR, MARK S, WIENER, JOHN J. M, GHOSH, BRAHMANANDA, ARORA, NIDHI, KREUTTER, KEVIN D, CHEN, WEI, BARBAY, JOSEPH KENT
Year of Publication 02.01.2024
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Year of Publication 02.01.2024
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Inhibitors of Bruton's tyrosine kinase and methods of their use
Bembenek, Scott D, Kreutter, Kevin D, Wiener, John J. M, Bacani, Genesis M, Arora, Nidhi, Ghosh, Brahmananda, Tichenor, Mark S, Edwards, James P, Barbay, Joseph Kent, Deckhut, Charlotte Pooley, Wei, Jianmei, Venable, Jennifer D
Year of Publication 03.05.2022
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Year of Publication 03.05.2022
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INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
Bembenek, Scott D, Kreutter, Kevin D, Bacani, Genesis M, Wiener, John J.M, Arora, Nidhi, Ghosh, Brahmananda, Tichenor, Mark S, Edwards, James P, Barbay, Joseph Kent, Deckhut, Charlotte Pooley, Wei, Jianmei, Venable, Jennifer D
Year of Publication 08.04.2021
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Year of Publication 08.04.2021
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Polycyclic compounds as inhibitors of bruton's tyrosine kinase
Bembenek, Scott D, Wu, Yao, Zhu, Yaoping, Bacani, Genesis M, Arora, Nidhi, Tichenor, Mark S, Xiao, Kun, Barbay, Joseph Kent, Wei, Jianmei, Zhang, Feihuang, Chen, Wei, Kreutter, Kevin, Wiener, John J. M, Li, Gang, Ghosh, Brahmananda, Cai, Min, Edwards, James P, Deckhut, Charlotte Pooley, Venable, Jennifer D
Year of Publication 24.09.2021
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Year of Publication 24.09.2021
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Inhibitors of Bruton's tyrosine kinase and methods of their use
Bembenek, Scott D, Wu, Yao, Zhu, Yaoping, Bacani, Genesis M, Arora, Nidhi, Tichenor, Mark S, Xiao, Kun, Zhang, Zheng, Barbay, Joseph Kent, Wei, Jianmei, Zhang, Feihuang, Chen, Wei, Kreutter, Kevin, Wiener, John J. M, Li, Gang, Ghosh, Brahmananda, Hao, Baoyu, Cai, Min, Edwards, James P, Deckhut, Charlotte Pooley, Venable, Jennifer D
Year of Publication 12.08.2021
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Year of Publication 12.08.2021
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Polycyclic compounds as inhibitors of Bruton's tyrosine kinase
Bembenek, Scott D, Wu, Yao, Zhu, Yaoping, Bacani, Genesis M, Arora, Nidhi, Tichenor, Mark S, Xiao, Kun, Barbay, Joseph Kent, Wei, Jianmei, Zhang, Feihuang, Chen, Wei, Kreutter, Kevin, Wiener, John J. M, Li, Gang, Ghosh, Brahmananda, Cai, Min, Edwards, James P, Deckhut, Charlotte Pooley, Venable, Jennifer D
Year of Publication 13.05.2021
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Year of Publication 13.05.2021
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COMPOSÉS POLYCYCLIQUES EN TANT QU'INHIBITEURS DE LA TYROSINE-KINASE DE BRUTON
WEI, Jianmei, ARORA, Nidhi, WIENER, John J. M, BARBAY, Joseph Kent, LI, Gang, BACANI, Genesis M, BEMBENEK, Scott D, ZHANG, Feihuang, ZHU, Yaoping, CHEN, Wei, DECKHUT, Charlotte Pooley, VENABLE, Jennifer D, EDWARDS, James P, WU, Yao, CAI, Min, GHOSH, Brahmananda, XIAO, Kun, KREUTTER, Kevin, TICHENOR, Mark S
Year of Publication 12.05.2021
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Year of Publication 12.05.2021
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POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE
WEI, Jianmei, ARORA, Nidhi, WIENER, John J. M, BARBAY, Joseph Kent, LI, Gang, BACANI, Genesis M, BEMBENEK, Scott D, ZHANG, Feihuang, ZHU, Yaoping, CHEN, Wei, DECKHUT, Charlotte Pooley, VENABLE, Jennifer D, EDWARDS, James P, WU, Yao, CAI, Min, GHOSH, Brahmananda, XIAO, Kun, KREUTTER, Kevin, TICHENOR, Mark S
Year of Publication 20.04.2021
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Year of Publication 20.04.2021
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POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE
VENABLE, JENNIFER D, WU, YAO, ZHANG, FEIHUANG, CAI, MIN, BEMBENEK, SCOTT D, XIAO, KUN, ZHU, YAOPING, EDWARDS, JAMES P, BACANI, GENESIS M, DECKHUT, CHARLOTTE POOLEY, WEI, JIANMEI, LI, GANG, TICHENOR, MARK S, KREUTTER, KEVIN, WIENER, JOHN J. M, GHOSH, BRAHMANANDA, ARORA, NIDHI, CHEN, WEI, BARBAY, JOSEPH KENT
Year of Publication 08.03.2021
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Year of Publication 08.03.2021
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Inhibitors of Bruton's tyrosine kinase and method of their use
Bembenek, Scott D, Wu, Yao, Zhu, Yaoping, Bacani, Genesis M, Arora, Nidhi, Tichenor, Mark S, Xiao, Kun, Barbay, Joseph Kent, Wei, Jianmei, Zhang, Feihuang, Chen, Wei, Kreutter, Kevin D, Wiener, John J. M, Li, Gang, Ghosh, Brahmananda, Cai, Min, Edwards, James P, Deckhut, Charlotte Pooley, Venable, Jennifer D
Year of Publication 02.03.2021
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Year of Publication 02.03.2021
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POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE
Bembenek, Scott D, Wu, Yao, Zhu, Yaoping, Bacani, Genesis M, Arora, Nidhi, Tichenor, Mark S, Xiao, Kun, Barbay, Joseph Kent, Wei, Jianmei, Zhang, Feihuang, Chen, Wei, Kreutter, Kevin, Wiener, John J. M, Li, Gang, Ghosh, Brahmananda, Cai, Min, Edwards, James P, Deckhut, Charlotte Pooley, Venable, Jennifer D
Year of Publication 13.11.2020
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Year of Publication 13.11.2020
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