Enhanced Floating-Point Multiply-Add with Full Denormal Support
Sohn, Jongwook, Dean, David K., Quintana, Eric, Wong, Wing Shek
Published in 2023 IEEE 30th Symposium on Computer Arithmetic (ARITH) (04.09.2023)
Published in 2023 IEEE 30th Symposium on Computer Arithmetic (ARITH) (04.09.2023)
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Conference Proceeding
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle
Mackman, Richard L, Steadman, Victoria A, Dean, David K, Jansa, Petr, Poullennec, Karine G, Appleby, Todd, Austin, Carol, Blakemore, Caroline A, Cai, Ruby, Cannizzaro, Carina, Chin, Gregory, Chiva, Jean-Yves C, Dunbar, Neil A, Fliri, Hans, Highton, Adrian J, Hui, Hon, Ji, Mingzhe, Jin, Haolun, Karki, Kapil, Keats, Andrew J, Lazarides, Linos, Lee, Yu-Jen, Liclican, Albert, Mish, Michael, Murray, Bernard, Pettit, Simon B, Pyun, Peter, Sangi, Michael, Santos, Rex, Sanvoisin, Jonathan, Schmitz, Uli, Schrier, Adam, Siegel, Dustin, Sperandio, David, Stepan, George, Tian, Yang, Watt, Gregory M, Yang, Hai, Schultz, Brian E
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Journal Article
Enhanced Floating-Point Adder with Full Denormal Support
Sohn, Jongwook, Dean, David K., Quintana, Eric, Wong, Wing Shek
Published in 2022 IEEE 29th Symposium on Computer Arithmetic (ARITH) (01.09.2022)
Published in 2022 IEEE 29th Symposium on Computer Arithmetic (ARITH) (01.09.2022)
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Conference Proceeding
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
Steadman, Victoria A, Pettit, Simon B, Poullennec, Karine G, Lazarides, Linos, Keats, Andrew J, Dean, David K, Stanway, Steven J, Austin, Carol A, Sanvoisin, Jonathan A, Watt, Gregory M, Fliri, Hans G, Liclican, Albert C, Jin, Debi, Wong, Melanie H, Leavitt, Stephanie A, Lee, Yu-Jen, Tian, Yang, Frey, Christian R, Appleby, Todd C, Schmitz, Uli, Jansa, Petr, Mackman, Richard L, Schultz, Brian E
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
Rate Acceleration of the Baylis−Hillman Reaction in Polar Solvents (Water and Formamide). Dominant Role of Hydrogen Bonding, Not Hydrophobic Effects, Is Implicated
Aggarwal, Varinder K, Dean, David K, Mereu, Andrea, Williams, Richard
Published in Journal of organic chemistry (25.01.2002)
Published in Journal of organic chemistry (25.01.2002)
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Journal Article
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
Takle, Andrew K., Brown, Murray J.B., Davies, Susannah, Dean, David K., Francis, Gerraint, Gaiba, Alessandra, Hird, Alex W., King, Frank D., Lovell, Peter J., Naylor, Antoinette, Reith, Alastair D., Steadman, Jon G., Wilson, David M.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Journal Article
Mechanism of action of species-selective P2X(7) receptor antagonists
Michel, Anton D, Ng, Sin-Wei, Roman, Shilina, Clay, William C, Dean, David K, Walter, Daryl S
Published in British journal of pharmacology (01.04.2009)
Published in British journal of pharmacology (01.04.2009)
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Journal Article
Mechanism of action of species‐selective P2X 7 receptor antagonists
Michel, Anton D, Ng, Sin‐Wei, Roman, Shilina, Clay, William C, Dean, David K, Walter, Daryl S
Published in British journal of pharmacology (01.04.2009)
Published in British journal of pharmacology (01.04.2009)
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Journal Article
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor
ABDI, Muna H, BESWICK, Paul J, LEJEUNE, Clarisse L, LIVERMORE, David G, MEDHURST, Stephen J, MICHEL, Anton D, MOSES, Andrew P, PAGE, Lee, PATEL, Sadhana, ROMAN, Shilina A, SENGER, Stefan, SLINGSBY, Brian, BILLINTON, Andy, STEADMAN, Jon G. A, STEVENS, Alexander J, WALTER, Daryl S, CHAMBERS, Laura J, CHARLTON, Andrew, COLLINS, Sue D, COLLIS, Katharine L, DEAN, David K, FONFRIA, Elena, GLEAVE, Robert J
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor
Abberley, Lee, Bebius, Aude, Beswick, Paul J, Billinton, Andy, Collis, Katharine L, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G A, Walter, Daryl S
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists
Wilson, David M., Apps, James, Bailey, Nicholas, Bamford, Mark J., Beresford, Isabel J., Brackenborough, Kim, Briggs, Michael A., Brough, Stephen, Calver, Andrew R., Crook, Barry, Davis, Rebecca K., Davis, Robert P., Davis, Susannah, Dean, David K., Harris, Leanne, Heslop, Teresa, Holland, Vicky, Jeffrey, Phillip, Panchal, Terrance A., Parr, Christopher A., Quashie, Nigel, Schogger, Joanne, Sehmi, Sanjeet S., Stean, Tania O., Steadman, Jon G.A., Trail, Brenda, Wald, Jeffrey, Worby, Angela, Takle, Andrew K., Witherington, Jason, Medhurst, Andrew D.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor
Abberley, Lee, Bebius, Aude, Beswick, Paul J., Billinton, Andy, Collis, Katharine L., Dean, David K., Fonfria, Elena, Gleave, Robert J., Medhurst, Stephen J., Michel, Anton D., Moses, Andrew P., Patel, Sadhana, Roman, Shilina A., Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G.A., Walter, Daryl S.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor
Beswick, Paul J, Billinton, Andy, Chambers, Laura J, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Roomans, Sue, Senger, Stefan, Stevens, Alexander J, Walter, Daryl S
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
The discovery of the benzazepine class of histamine H3 receptor antagonists
Wilson, David M., Apps, James, Bailey, Nicholas, Bamford, Mark J., Beresford, Isabel J., Briggs, Michael A., Calver, Andrew R., Crook, Barry, Davis, Robert P., Davis, Susannah, Dean, David K., Harris, Leanne, Heightman, Tom D., Panchal, Terry, Parr, Christopher A., Quashie, Nigel, Steadman, Jon G.A., Schogger, Joanne, Sehmi, Sanjeet S., Stean, Tania O., Takle, Andrew K., Trail, Brenda K., White, Trevor, Witherington, Jason, Worby, Angela, Medhurst, Andrew D.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase
Takle, Andrew K., Bamford, Mark J., Davies, Susannah, Davis, Robert P., Dean, David K., Gaiba, Alessandra, Irving, Elaine A., King, Frank D., Naylor, Antoinette, Parr, Christopher A., Ray, Alison M., Reith, Alastair D., Smith, Beverley B., Staton, Penelope C., Steadman, Jon G.A., Stean, Tania O., Wilson, David M.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Mechanism of action of species‐selective P2X7 receptor antagonists
Michel, Anton D, Ng, Sin‐Wei, Roman, Shilina, Clay, William C, Dean, David K, Walter, Daryl S
Published in British journal of pharmacology (01.04.2009)
Published in British journal of pharmacology (01.04.2009)
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Journal Article
Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification
Heightman, Tom D., Scott, Jackie S., Longley, Mark, Bordas, Vincent, Dean, David K., Elliott, Richard, Hutley, Gail, Witherington, Jason, Abberley, Lee, Passingham, Barry, Berlanga, Manuela, de los Frailes, Maite, Wise, Alan, Powney, Ben, Muir, Alison, McKay, Fiona, Butler, Sharon, Winborn, Kim, Gardner, Christopher, Darton, Jill, Campbell, Colin, Sanger, Gareth
Published in Bioorganic & medicinal chemistry letters (01.12.2007)
Published in Bioorganic & medicinal chemistry letters (01.12.2007)
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Journal Article
Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation
Witherington, Jason, Abberley, Lee, Briggs, Michael A., Collis, Katharine, Dean, David K., Gaiba, Alessandra, King, N. Paul, Kraus, Helmut, Shuker, Nicola, Steadman, Jon G.A., Takle, Andrew K., Sanger, Gareth, Wadsworth, Graham, Butler, Sharon, McKay, Fiona, Muir, Alison, Winborn, Kim, Heightman, Tom D.
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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Journal Article
Structure–activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor
Beswick, Paul J., Billinton, Andy, Chambers, Laura J., Dean, David K., Fonfria, Elena, Gleave, Robert J., Medhurst, Stephen J., Michel, Anton D., Moses, Andrew P., Patel, Sadhana, Roman, Shilina A., Roomans, Sue, Senger, Stefan, Stevens, Alexander J., Walter, Daryl S.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors
Bamford, Mark J., Alberti, Michael J., Bailey, Nicholas, Davies, Susannah, Dean, David K., Gaiba, Alessandra, Garland, Stephen, Harling, John D., Jung, David K., Panchal, Terence A., Parr, Christopher A., Steadman, Jon G., Takle, Andrew K., Townsend, James T., Wilson, David M., Witherington, Jason
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
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Journal Article