A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
Beumer, Joep, Geurts, Maarten H., Lamers, Mart M., Puschhof, Jens, Zhang, Jingshu, van der Vaart, Jelte, Mykytyn, Anna Z., Breugem, Tim I., Riesebosch, Samra, Schipper, Debby, van den Doel, Petra B., de Lau, Wim, Pleguezuelos-Manzano, Cayetano, Busslinger, Georg, Haagmans, Bart L., Clevers, Hans
Published in Nature communications (17.09.2021)
Published in Nature communications (17.09.2021)
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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
de Lau, Wim, Peng, Weng Chuan, Gros, Piet, Clevers, Hans
Published in Genes & development (15.02.2014)
Published in Genes & development (15.02.2014)
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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
Janda, Claudia Y, Dang, Luke T, You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A, Yan, Kelley S, Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D, Williams, Bart O, Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J, Garcia, K Christopher
Published in Nature (London) (11.05.2017)
Published in Nature (London) (11.05.2017)
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Journal Article
Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells
Kemper, Kristel, Prasetyanti, Pramudita R., De Lau, Wim, Rodermond, Hans, Clevers, Hans, Medema, Jan Paul
Published in Stem cells (Dayton, Ohio) (01.11.2012)
Published in Stem cells (Dayton, Ohio) (01.11.2012)
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Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo
Miao, Yi, Ha, Andrew, de Lau, Wim, Yuki, Kanako, Santos, António J.M., You, Changjiang, Geurts, Maarten H., Puschhof, Jens, Pleguezuelos-Manzano, Cayetano, Peng, Weng Chuan, Senlice, Ramazan, Piani, Carol, Buikema, Jan W., Gbenedio, Oghenekevwe M., Vallon, Mario, Yuan, Jenny, de Haan, Sanne, Hemrika, Wieger, Rösch, Kathrin, Dang, Luke T., Baker, David, Ott, Melanie, Depeille, Philippe, Wu, Sean M., Drost, Jarno, Nusse, Roeland, Roose, Jeroen P., Piehler, Jacob, Boj, Sylvia F., Janda, Claudia Y., Clevers, Hans, Kuo, Calvin J., Garcia, K. Christopher
Published in Cell stem cell (05.11.2020)
Published in Cell stem cell (05.11.2020)
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Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured “Miniguts”
de Lau, Wim, Kujala, Pekka, Schneeberger, Kerstin, Middendorp, Sabine, Li, Vivian S. W., Barker, Nick, Martens, Anton, Hofhuis, Frans, DeKoter, Rodney P., Peters, Peter J., Nieuwenhuis, Edward, Clevers, Hans
Published in Molecular and Cellular Biology (01.09.2012)
Published in Molecular and Cellular Biology (01.09.2012)
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Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling
Peng, Weng Chuan, de Lau, Wim, Madoori, Pramod K, Forneris, Federico, Granneman, Joke C M, Clevers, Hans, Gros, Piet
Published in PloS one (12.12.2013)
Published in PloS one (12.12.2013)
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Journal Article
Method for estimating the single molecular affinity
Schasfoort, Richard B.M., de Lau, Wim, van der Kooi, Alex, Clevers, Hans, Engbers, Gerard H.M.
Published in Analytical biochemistry (15.02.2012)
Published in Analytical biochemistry (15.02.2012)
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Journal Article
Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins
Ren, Zemin, van Andel, Harmen, de Lau, Wim, Hartholt, Robin B., Maurice, Madelon M., Clevers, Hans, Kersten, Marie José, Spaargaren, Marcel, Pals, Steven T.
Published in Blood (01.03.2018)
Published in Blood (01.03.2018)
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Journal Article
Lgr5 homologues associate with Wnt receptors and mediate R―spondin signalling
DE LAU, Wim, BARKER, Nick, STANGE, Daniel E, VAN ES, Johan E, GUARDAVACCARO, Daniele, SCHASFOORT, Richard B. M, MOHRI, Yasuaki, NISHIMORI, Katsuhiko, MOHAMMED, Shabaz, HECK, Albert J. R, CLEVERS, Hans, LOW, Teck Y, KOO, Bon-Kyoung, LI, Vivian S. W, TEUNISSEN, Hans, KUJALA, Pekka, HAEGEBARTH, Andrea, PETERS, Peter J, VAN DE WETERING, Marc
Published in Nature (London) (18.08.2011)
Published in Nature (London) (18.08.2011)
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Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins
van Andel, Harmen, Ren, Zemin, Koopmans, Iris, Joosten, Sander P. J., Kocemba, Kinga A., de Lau, Wim, Kersten, Marie José, de Bruin, Alexander M., Guikema, Jeroen E. J., Clevers, Hans, Spaargaren, Marcel, Pals, Steven T.
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2017)
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The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
van de Wetering, Marc, Sancho, Elena, Verweij, Cornelis, de Lau, Wim, Oving, Irma, Hurlstone, Adam, van der Horn, Karin, Batlle, Eduard, Coudreuse, Damien, Haramis, Anna-Pavlina, Tjon-Pon-Fong, Menno, Moerer, Petra, van den Born, Maaike, Soete, Gwen, Pals, Steven, Eilers, Martin, Medema, Rene, Clevers, Hans
Published in Cell (18.10.2002)
Published in Cell (18.10.2002)
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The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1
DE LAU, W. B. M, HURENKAMP, J, BERENDES, P, TOUW, I. P, CLEVERS, H. C, VAN DIJK, M. A
Published in Oncogene (30.07.1998)
Published in Oncogene (30.07.1998)
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CD8 T cell activation after intravenous administration of CD3×CD19 bispecific antibody in patients with non-Hodgkin lymphoma
DE GAST, G. C, HAAGEN, I.-A, DE LAU, W. B. M, BAST, B. J. E. G, VAN HOUTEN, A. A, KLEIN, S. C, DUITS, A. J, DE WEGER, R. A, VROOM, T. M, CLARK, M. R, PHILLIPS, J, VAN DIJK, A. J. G
Published in Cancer Immunology, Immunotherapy (01.11.1995)
Published in Cancer Immunology, Immunotherapy (01.11.1995)
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Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids
Herpers, Bram, Roovers, Rob, Eppink, Berina, Wetering, Marc Van de, Yan, Kuan, Salinaro, Lucia, Lau, Wim De, Clevers, Hans, Vries, Robert, Throsby, Mark, Price, Leo
Published in Clinical cancer research (15.08.2016)
Published in Clinical cancer research (15.08.2016)
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