Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells
Hof, Willemien F J, Visser, Miranda, de Jong, Joyce J, Rajasekar, Marian N, Schuringa, Jan Jacob, de Graaf, Inge A M, Touw, Daan J, Dekkers, Bart G J
Published in Toxins (01.01.2024)
Published in Toxins (01.01.2024)
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Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N‑Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group
Muenzner, Julienne K, Rehm, Tobias, Biersack, Bernhard, Casini, Angela, de Graaf, Inge A. M, Worawutputtapong, Pawida, Noor, Awal, Kempe, Rhett, Brabec, Viktor, Kasparkova, Jana, Schobert, Rainer
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study
Estrada‐Ortiz, Natalia, Guarra, Federica, de Graaf, Inge A. M., Marchetti, Lorella, de Jager, Marina H., Groothuis, Geny M. M., Gabbiani, Chiara, Casini, Angela
Published in ChemMedChem (07.09.2017)
Published in ChemMedChem (07.09.2017)
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Induction of Metabolism and Transport in Human Intestine: Validation of Precision-Cut Slices as a Tool to Study Induction of Drug Metabolism in Human Intestine in Vitro
VAN DE KERKHOF, Esther G, DE GRAAF, Inge A. M, UNGELL, Anna-Lena B, GROOTHUIS, Geny M. M
Published in Drug metabolism and disposition (01.03.2008)
Published in Drug metabolism and disposition (01.03.2008)
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On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent
Spreckelmeyer, Sarah, Estrada-Ortiz, Natalia, Prins, Gerian G H, van der Zee, Margot, Gammelgaard, Bente, Stürup, Stefan, de Graaf, Inge A M, Groothuis, Geny M M, Casini, Angela
Published in Metallomics (01.12.2017)
Published in Metallomics (01.12.2017)
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Journal Article
On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices
van Midwoud, Paul M, Janssen, Joost, Merema, Marjolijn T, de Graaf, Inge A. M, Groothuis, Geny M. M, Verpoorte, Elisabeth
Published in Analytical chemistry (Washington) (01.01.2011)
Published in Analytical chemistry (Washington) (01.01.2011)
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Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies
de Graaf, Inge A M, Olinga, Peter, de Jager, Marina H, Merema, Marjolijn T, de Kanter, Ruben, van de Kerkhof, Esther G, Groothuis, Geny M M
Published in Nature protocols (01.09.2010)
Published in Nature protocols (01.09.2010)
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Improved Synthesis of N‑Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity
Daum, Steffen, Chekhun, Vasiliy F, Todor, Igor N, Lukianova, Natalia Yu, Shvets, Yulia V, Sellner, Leopold, Putzker, Kerstin, Lewis, Joe, Zenz, Thorsten, de Graaf, Inge A. M, Groothuis, Geny M. M, Casini, Angela, Zozulia, Oleksii, Hampel, Frank, Mokhir, Andriy
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver
Daga, Martina, de Graaf, Inge A.M., Argenziano, Monica, Barranco, Ana Sofia Martinez, Loeck, Maximillian, Al-Adwi, Yehya, Cucci, Marie Angele, Caldera, Fabrizio, Trotta, Francesco, Barrera, Giuseppina, Casini, Angela, Cavalli, Roberta, Pizzimenti, Stefania
Published in Toxicology in vitro (01.06.2020)
Published in Toxicology in vitro (01.06.2020)
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Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations
VAN DE KERKHOF, Esther G, UNGELL, Anna-Lena B, SJÖBERG, Asa K, DE JAGER, Marina H, HILGENDORF, Constanze, DE GRAAF, Inge A. M, GROOTHUIS, Geny M. M
Published in Drug metabolism and disposition (01.11.2006)
Published in Drug metabolism and disposition (01.11.2006)
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Journal Article
Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices
Martinec, Ondrej, Biel, Carin, de Graaf, Inge A. M., Huliciak, Martin, de Jong, Koert P., Staud, Frantisek, Cecka, Filip, Olinga, Peter, Vokral, Ivan, Cerveny, Lukas
Published in Frontiers in pharmacology (09.06.2021)
Published in Frontiers in pharmacology (09.06.2021)
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Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring
Lkhagvadorj, Khosbayar, Meyer, Karolin F., Verweij, Laura P., Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W., de Graaf, Inge A. M., Plösch, Torsten, Hylkema, Machteld N.
Published in Epigenetics (01.12.2020)
Published in Epigenetics (01.12.2020)
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Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation
Lkhagvadorj, Khosbayar, Zeng, Zhijun, Meyer, Karolin F, Verweij, Laura P, Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W, de Graaf, Inge A M, Plösch, Torsten, Hylkema, Machteld N
Published in International journal of molecular sciences (26.12.2020)
Published in International journal of molecular sciences (26.12.2020)
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Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study
Bigaeva, Emilia, Bomers, Jordy J.M., Biel, Carin, Mutsaers, Henricus A.M., de Graaf, Inge A.M., Boersema, Miriam, Olinga, Peter
Published in Toxicology in vitro (01.09.2019)
Published in Toxicology in vitro (01.09.2019)
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Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury
van Furth, L. Annick, Leuvenink, Henri G. D., Seras, Lorina, de Graaf, Inge A. M., Olinga, Peter, van Leeuwen, L. Leonie
Published in Transplantology (Basel, Switzerland) (01.06.2022)
Published in Transplantology (Basel, Switzerland) (01.06.2022)
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Journal Article
CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES
VAN DE KERKHOF, Esther G, DE GRAAF, Inge A. M, DE JAGER, Marina H, MEIJER, Dirk K. F, GROOTHUIS, Geny M. M
Published in Drug metabolism and disposition (01.11.2005)
Published in Drug metabolism and disposition (01.11.2005)
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The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
Li, Ming, de Graaf, Inge A.M., van de Steeg, Evita, de Jager, Marina H., Groothuis, Geny M.M.
Published in Toxicology in vitro (01.04.2017)
Published in Toxicology in vitro (01.04.2017)
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Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands
Estrada-Ortiz, Natalia, Lopez-Gonzales, Elena, Woods, Ben, Stürup, Stefan, de Graaf, Inge A M, Groothuis, Geny M M, Casini, Angela
Published in Toxicology research (Cambridge) (01.11.2019)
Published in Toxicology research (Cambridge) (01.11.2019)
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