Structural basis for itraconazole-mediated NPC1 inhibition
Long, Tao, Qi, Xiaofeng, Hassan, Abdirahman, Liang, Qiren, De Brabander, Jef K, Li, Xiaochun
Published in Nature communications (09.01.2020)
Published in Nature communications (09.01.2020)
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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK‐925 and ARN‐776 in narcoleptic orexin/tTA; TetO‐DTA mice
Sun, Yu, Ranjan, Alok, Tisdale, Ryan, Ma, Shun‐Chieh, Park, Sunmee, Haire, Meghan, Heu, Jasmine, Morairty, Stephen R., Wang, Xiaoyu, Rosenbaum, Daniel M., Williams, Noelle S., De Brabander, Jef K., Kilduff, Thomas S.
Published in Journal of sleep research (01.08.2023)
Published in Journal of sleep research (01.08.2023)
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Journal Article
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma
Shi, Yufeng, Lim, S Kyun, Liang, Qiren, Iyer, Swathi V, Wang, Hua-Yu, Wang, Zilai, Xie, Xuanhua, Sun, Daochun, Chen, Yu-Jung, Tabar, Viviane, Gutin, Philip, Williams, Noelle, De Brabander, Jef K, Parada, Luis F
Published in Nature (London) (01.03.2019)
Published in Nature (London) (01.03.2019)
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A Concise Synthesis of Berkelic Acid Inspired by Combining the Natural Products Spicifernin and Pulvilloric Acid
Bender, Christopher F., Yoshimoto, Francis K., Paradise, Christopher L., Brabander, Jef K. De
Published in Journal of the American Chemical Society (19.08.2009)
Published in Journal of the American Chemical Society (19.08.2009)
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Journal Article
Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A
Jiang, Xin, Liu, Bo, Lebreton, Sylvain, De Brabander, Jef K
Published in Journal of the American Chemical Society (23.05.2007)
Published in Journal of the American Chemical Society (23.05.2007)
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Journal Article
Molecular mechanism of the wake-promoting agent TAK-925
Yin, Jie, Kang, Yanyong, McGrath, Aaron P, Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K, Rosenbaum, Daniel M
Published in Nature communications (25.05.2022)
Published in Nature communications (25.05.2022)
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Journal Article
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1
Trinh, Michael N., Lu, Feiran, Li, Xiaochun, Das, Akash, Liang, Qiren, De Brabander, Jef K., Brown, Michael S., Goldstein, Joseph L.
Published in Proceedings of the National Academy of Sciences - PNAS (03.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (03.01.2017)
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Journal Article
Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer
Zhang, Lu, Theodoropoulos, Panayotis C, Eskiocak, Ugur, Wang, Wentian, Moon, Young-Ah, Posner, Bruce, Williams, Noelle S, Wright, Woodring E, Kim, Sang Bum, Nijhawan, Deepak, De Brabander, Jef K, Shay, Jerry W
Published in Science translational medicine (19.10.2016)
Published in Science translational medicine (19.10.2016)
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Journal Article
Reply to: The G protein preference of orexin receptors is currently an unresolved issue
Yin, Jie, Kang, Yanyong, McGrath, Aaron P, Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K, Rosenbaum, Daniel M
Published in Nature communications (01.06.2023)
Published in Nature communications (01.06.2023)
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Journal Article
Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B
Feng, Yu, Liu, Jun, Carrasco, Yazmin P, MacMillan, John B, De Brabander, Jef K
Published in Journal of the American Chemical Society (08.06.2016)
Published in Journal of the American Chemical Society (08.06.2016)
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Journal Article
Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles
Bimbo, Luis M, Denisova, Oxana V, Mäkilä, Ermei, Kaasalainen, Martti, De Brabander, Jef K, Hirvonen, Jouni, Salonen, Jarno, Kakkola, Laura, Kainov, Denis, Santos, Hélder A
Published in ACS nano (27.08.2013)
Published in ACS nano (27.08.2013)
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Journal Article
Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs
Adams, Christopher M, Reitz, Julian, De Brabander, Jef K, Feramisco, Jamison D, Li, Lu, Brown, Michael S, Goldstein, Joseph L
Published in The Journal of biological chemistry (10.12.2004)
Published in The Journal of biological chemistry (10.12.2004)
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Journal Article
Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
Eskiocak, Banu, McMillan, Elizabeth A, Mendiratta, Saurabh, Kollipara, Rahul K, Zhang, Hailei, Humphries, Caroline G, Wang, Changguang, Garcia-Rodriguez, Jose, Ding, Ming, Zaman, Aubhishek, Rosales, Tracy I, Eskiocak, Ugur, Smith, Michael P, Sudderth, Jessica, Komurov, Kakajan, Deberardinis, Ralph J, Wellbrock, Claudia, Davies, Michael A, Wargo, Jennifer A, Yu, Yonghao, De Brabander, Jef K, Williams, Noelle S, Chin, Lynda, Rizos, Helen, Long, Georgina V, Kittler, Ralf, White, Michael A
Published in Cancer discovery (01.08.2017)
Published in Cancer discovery (01.08.2017)
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Journal Article
Structural insights for selective disruption of Beclin 1 binding to Bcl-2
Pan, Yun-Zu, Liang, Qiren, Tomchick, Diana R, De Brabander, Jef K, Rizo, Josep
Published in Communications biology (24.10.2023)
Published in Communications biology (24.10.2023)
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Journal Article
Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes
Kissing, Sandra, Rudnik, Sönke, Damme, Markus, Lüllmann-Rauch, Renate, Ichihara, Atsuhiro, Kornak, Uwe, Eskelinen, Eeva-Liisa, Jabs, Sabrina, Heeren, Jörg, De Brabander, Jef K., Haas, Albert, Saftig, Paul
Published in Autophagy (03.04.2017)
Published in Autophagy (03.04.2017)
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Journal Article
The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections
Müller, Konstantin H, Kainov, Denis E, El Bakkouri, Karim, Saelens, Xavier, De Brabander, Jef K, Kittel, Christian, Samm, Elisabeth, Muller, Claude P
Published in British journal of pharmacology (01.09.2011)
Published in British journal of pharmacology (01.09.2011)
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Journal Article
Synthesis and structure–activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs
Garcia-Rodriguez, Jose, Mendiratta, Saurabh, White, Michael A., Xie, Xiao-Song, De Brabander, Jef K.
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
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