The Identification of a Novel Phosphodiesterase 4 Inhibitor, 1-Ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of Emetogenicity
Davis, T Gregg, Peterson, John J, Kou, Jen-Pyng, Capper-Spudich, Elizabeth A, Ball, Doug, Nials, Anthony T, Wiseman, Joanne, Solanke, Yemisi E, Lucas, Fiona S, Williamson, Richard A, Ferrari, Livia, Wren, Paul, Knowles, Richard G, Barnette, Mary S, Podolin, Patricia L
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Rapid Lipid Mediator Profiling by Convergence Chromatography-MS/MS
Metzler, Guille, King, Richard C, Fernández-Metzler, Carmen, Das, Amitava, Davis, T Gregg, Bajrami, Besnik, Bretschneider, Tom, Kvaskoff, David
Published in Methods in molecular biology (Clifton, N.J.) (2025)
Published in Methods in molecular biology (Clifton, N.J.) (2025)
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GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species
Rutter, A Richard, Poffe, Alessandro, Cavallini, Palmina, Davis, T Gregg, Schneck, Jessica, Negri, Michele, Vicentini, Elena, Montanari, Dino, Arban, Roberto, Gray, Frank A, Davies, Ceri H, Wren, Paul B
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Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)
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Prostaglandin Metabolites Analysis in Urine by LC-MS/MS
Metzler, Guille, Day, Lily A, King, Richard C, Fernández-Metzler, Carmen, Das, Amitava, Davis, T Gregg, Bajrami, Besnik, Bretschneider, Tom, Kvaskoff, David
Published in Methods in molecular biology (Clifton, N.J.) (2025)
Published in Methods in molecular biology (Clifton, N.J.) (2025)
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Inhibition of Invariant Chain Processing, Antigen-Induced Proliferative Responses, and the Development of Collagen-Induced Arthritis and Experimental Autoimmune Encephalomyelitis by a Small Molecule Cysteine Protease Inhibitor
Podolin, Patricia L, Bolognese, Brian J, Carpenter, Donald C, Davis, T. Gregg, Johanson, Roy A, Fox, Josephine H, Long, Edward, III, Dong, Xiaoyang, Marquis, Robert W, LoCastro, Stephen M, Terfloth, Gerald J, Kurali, Edit, Peterson, John J, Smith, Brian R, McQueney, Michael S, Yamashita, Dennis S, Capper-Spudich, Elizabeth A
Published in The Journal of immunology (1950) (15.06.2008)
Published in The Journal of immunology (1950) (15.06.2008)
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Endothelin B Receptor Modulates Inflammatory Pain and Cutaneous Inflammation
Griswold, D E, Douglas, S A, Martin, L D, Davis, T G, Davis, L, Ao, Z, Luttmann, M A, Pullen, M, Nambi, P, Hay, D W, Ohlstein, E H
Published in Molecular pharmacology (01.10.1999)
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Published in Molecular pharmacology (01.10.1999)
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Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation
Podolin, Patricia L., Callahan, James F., Bolognese, Brian J., Li, Yue H., Carlson, Karey, Davis, T. Gregg, Mellor, Geoff W., Evans, Christopher, Roshak, Amy K.
Published in The Journal of pharmacology and experimental therapeutics (01.01.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2005)
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Targeted disruption of the endothelin-B-receptor gene attenuates inflammatory nociception and cutaneous inflammation in mice
Griswold, D E, Douglas, S A, Martin, L D, Davis, T G, Davis, L, Ao, Z, Luttmann, M A, Pullen, M, Nambi, P, Hay, D W, Ohlstein, E H
Published in Journal of cardiovascular pharmacology (2000)
Published in Journal of cardiovascular pharmacology (2000)
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The Identification of a Novel Phosphodiesterase 4 Inhibitor, 1-Ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}- N -(tetrahydro-2 H -pyran-4-yl)-1 H -pyrazolo[3,4- b ]pyridin-4-amine (EPPA-1), with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of Emetogenicity
Davis, T. Gregg, Peterson, John J., Kou, Jen-Pyng, Capper-Spudich, Elizabeth A., Ball, Doug, Nials, Anthony T., Wiseman, Joanne, Solanke, Yemisi E., Lucas, Fiona S., Williamson, Richard A., Ferrari, Livia, Wren, Paul, Knowles, Richard G., Barnette, Mary S., Podolin, Patricia L.
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation
Podolin, Patricia L, Callahan, James F, Bolognese, Brian J, Li, Yue H, Carlson, Karey, Davis, T Gregg, Mellor, Geoff W, Evans, Christopher, Roshak, Amy K
Published in The Journal of pharmacology and experimental therapeutics (01.01.2005)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.2005)
Journal Article
Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation
Patricia L. Podolin, James F. Callahan, Brian J. Bolognese, Yue H. Li, Karey Carlson, T. Gregg Davis, Geoff W. Mellor, Christopher Evans, Amy K. Roshak
Published in The Journal of pharmacology and experimental therapeutics (01.01.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2005)
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Year of Publication 18.04.2017
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Year of Publication 18.04.2017
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Year of Publication 24.03.2015
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Year of Publication 15.01.2015
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Year of Publication 10.07.2014
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Year of Publication 10.07.2014
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TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS
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Year of Publication 31.03.2014
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Year of Publication 31.03.2014
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TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS
RAST BRYSON, CELESTE LAURA L, SCHLACHTER STEPHEN T, GROSS STEFAN D, TOPALOV GEORGE T, WRIGHT A. DALE, HICKS JULIE MARIE, ZHAO QIAN, DELISLE ROBERT KIRK, HICKEN ERIK JAMES, ROBINSON JOHN E, ALLEN SHELLEY, PHENEGER JED, MUNSON MARK C, LYSSIKATOS JOSEPH P, JACKSON LEILA J, KALLAN NICHOLAS C, DAVIS T. GREGG, MARMSATER FREDRIK P
Year of Publication 13.02.2014
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Year of Publication 13.02.2014
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TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS
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Year of Publication 03.01.2014
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Year of Publication 03.01.2014
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TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS
RAST BRYSON, CELESTE LAURA L, SCHLACHTER STEPHEN T, GROSS STEFAN D, GRESCHUK JULIE MARIE, TOPALOV GEORGE T, WRIGHT A. DALE, ZHAO QIAN, DELISLE ROBERT KIRK, HICKEN ERIK JAMES, ROBINSON JOHN E, ALLEN SHELLEY, PHENEGER JED, MUNSON MARK C, LYSSIKATOS JOSEPH P, JACKSON LEILA J, KALLAN NICHOLAS C, DAVIS T. GREGG, MARMSATER FREDRIK P
Year of Publication 31.12.2013
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Year of Publication 31.12.2013
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