Discovery of 5-Chloro-N 2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N 4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway
Ioannidis, Stephanos, Lamb, Michelle L, Wang, Tao, Almeida, Lynsie, Block, Michael H, Davies, Audrey M, Peng, Bo, Su, Mei, Zhang, Hai-Jun, Hoffmann, Ethan, Rivard, Caroline, Green, Isabelle, Howard, Tina, Pollard, Hannah, Read, Jon, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Ye, Minwei, Huszar, Dennis, Zinda, Michael
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Journal Article
Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2
Gozgit, Joseph M., Bebernitz, Geraldine, Patil, Pankaj, Ye, Minwei, Parmentier, Julie, Wu, Jiaquan, Su, Nancy, Wang, Tao, Ioannidis, Stephanos, Davies, Audrey, Huszar, Dennis, Zinda, Michael
Published in The Journal of biological chemistry (21.11.2008)
Published in The Journal of biological chemistry (21.11.2008)
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Journal Article
Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent
Theoclitou, Maria-Elena, Aquila, Brian, Block, Michael H, Brassil, Patrick J, Castriotta, Lillian, Code, Erin, Collins, Michael P, Davies, Audrey M, Deegan, Tracy, Ezhuthachan, Jayachandran, Filla, Sandra, Freed, Ellen, Hu, Haiqing, Huszar, Dennis, Jayaraman, Muthusamy, Lawson, Deborah, Lewis, Paula M, Nadella, Murali V. P, Oza, Vibha, Padmanilayam, Maniyan, Pontz, Timothy, Ronco, Lucienne, Russell, Daniel, Whitston, David, Zheng, Xiaolan
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases
Wang, Tao, Block, Michael A., Cowen, Scott, Davies, Audrey M., Devereaux, Erik, Gingipalli, Lakshmaiah, Johannes, Jeffrey, Larsen, Nicholas A., Su, Qibin, Tucker, Julie A., Whitston, David, Wu, Jiaquan, Zhang, Hai-Jun, Zinda, Michael, Chuaqui, Claudio
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Journal Article
Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases
Wang, Tao, Lamb, Michelle L, Scott, David A, Wang, Haixia, Block, Michael H, Lyne, Paul D, Lee, John W, Davies, Audrey M, Zhang, Hai-Jun, Zhu, Yanyi, Gu, Fei, Han, Yongxin, Wang, Bin, Mohr, Peter J, Kaus, Robert J, Josey, John A, Hoffmann, Ethan, Thress, Ken, MacIntyre, Terry, Wang, Haiyun, Omer, Charles A, Yu, Dingwei
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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Journal Article
Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors
Ioannidis, Stephanos, Lamb, Michelle L., Davies, Audrey M., Almeida, Lynsie, Su, Mei, Bebernitz, Geraldine, Ye, Minwei, Bell, Kirsten, Alimzhanov, Marat, Zinda, Michael
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Journal Article
In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors
Wang, Tao, Ioannidis, Stephanos, Almeida, Lynsie, Block, Michael H., Davies, Audrey M., Lamb, Michelle L., Scott, David A., Su, Mei, Zhang, Hai-Jun, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Zinda, Michael
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase
Scott, David A., Balliet, Carrie L., Cook, Donald J., Davies, Audrey M., Gero, Thomas W., Omer, Charles A., Poondru, Srinivasu, Theoclitou, Maria-Elena, Tyurin, Boris, Zinda, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Structure-activity studies of a series of dipyrazolo[3,4-b :3', 4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1
GREEN, Neal J, JASON XIANG, JING CHEN, LIHREN CHEN, DAVIES, Audrey M, ERBE, Dave, TAM, Steve, TOBIN, James F
Published in Bioorganic & medicinal chemistry (03.07.2003)
Published in Bioorganic & medicinal chemistry (03.07.2003)
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Journal Article
Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway
Ioannidis, Stephanos, Lamb, Michelle L, Wang, Tao, Almeida, Lynsie, Block, Michael H, Davies, Audrey M, Peng, Bo, Su, Mei, Zhang, Hai-Jun, Hoffmann, Ethan, Rivard, Caroline, Green, Isabelle, Howard, Tina, Pollard, Hannah, Read, Jon, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Ye, Minwei, Huszar, Dennis, Zinda, Michael
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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