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An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis
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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP
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Lobell, Robert B, Liu, Dongming, Buser, Carolyn A, Davide, Joseph P, DePuy, Elizabeth, Hamilton, Kelly, Koblan, Kenneth S, Lee, Yih, Mosser, Scott, Motzel, Sherri L, Abbruzzese, James L, Fuchs, Charles S, Rowinsky, Eric K, Rubin, Eric H, Sharma, Sunil, Deutsch, Paul J, Mazina, Kathryn E, Morrison, Briggs W, Wildonger, Lynne, Yao, Siu-Long, Kohl, Nancy E
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Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver
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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer
Cox, Christopher D, Coleman, Paul J, Breslin, Michael J, Whitman, David B, Garbaccio, Robert M, Fraley, Mark E, Buser, Carolyn A, Walsh, Eileen S, Hamilton, Kelly, Schaber, Michael D, Lobell, Robert B, Tao, Weikang, Davide, Joseph P, Diehl, Ronald E, Abrams, Marc T, South, Vicki J, Huber, Hans E, Torrent, Maricel, Prueksaritanont, Thomayant, Li, Chunze, Slaughter, Donald E, Mahan, Elizabeth, Fernandez-Metzler, Carmen, Yan, Youwei, Kuo, Lawrence C, Kohl, Nancy E, Hartman, George D
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Diaryl ether inhibitors of farnesyl-protein transferase
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Published in Bioorganic & medicinal chemistry letters (21.05.2001)
Published in Bioorganic & medicinal chemistry letters (21.05.2001)
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The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases
Tucker, Thomas J, Abrams, Marc T, Buser, Carolyn A, Davide, Joseph P, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Huber, Hans E, Liu, Dongming, Lobell, Robert B, Lumma, William C, Robinson, Ronald G, Sisko, John T, Smith, Anthony M
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
Kohl, N E, Omer, C A, Conner, M W, Anthony, N J, Davide, J P, deSolms, S J, Giuliani, E A, Gomez, R P, Graham, S L, Hamilton, K
Published in Nature medicine (01.08.1995)
Published in Nature medicine (01.08.1995)
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Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl :protein transferase inhibitor
OMER, C. A, ZUNXUAN CHEN, DAVIDE, J. P, ELLIS, M. S, GIBBS, J. B, GREENBERG, I, HAMILTON, K, KOBLAN, K. S, KRAL, A. M, DONGMING LIU, LOBELL, R. B, MILLER, P. J, DIEHL, R. E, MOSSER, S. D, O'NEILL, T. J, RANDS, E, SCHABER, M. D, SENDERAK, E. T, OLIFF, A, KOHL, N. E, CONNER, M. W, CHEN, H. Y, TRUMBAUER, M. E, GOPAL-TRUTER, S, SEEBURGER, G, BHIMNATHWALA, H, ABRAMS, M. T
Published in Cancer research (Chicago, Ill.) (15.05.2000)
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Published in Cancer research (Chicago, Ill.) (15.05.2000)
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Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP
Garbaccio, Robert M., Tasber, Edward S., Neilson, Lou Anne, Coleman, Paul J., Fraley, Mark E., Olson, Christy, Bergman, Jeff, Torrent, Maricel, Buser, Carolyn A., Rickert, Keith, Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Tao, Weikang, South, Vicki J., Diehl, Ronald E., Davide, Joseph P., Yan, Youwei, Kuo, Lawrence C., Li, Chunze, Prueksaritanont, Thomayant, Fernandez-Metzler, Carmen, Mahan, Elizabeth A., Slaughter, Donald E., Salata, Joseph J., Kohl, Nancy E., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant
LaRosa, Gregory J., Davide, Joseph P., Weinhold, Kent, Waterbury, Julie A., Profy, Albert T., Lewis, John A., Langlois, Alphonse J., Dreesman, Gordon R., Boswell, R. Neal, Shadduck, Phillip, Holley, L. Howard, Karplus, Martin, Bolognesi, Dani P., Matthews, Thomas J., Emini, Emilio A., Putney, Scott D.
Published in Science (American Association for the Advancement of Science) (24.08.1990)
Published in Science (American Association for the Advancement of Science) (24.08.1990)
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Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP
Coleman, Paul J., Schreier, John D., Cox, Christopher D., Fraley, Mark E., Garbaccio, Robert M., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Rickert, Keith, Tao, Weikang, Diehl, Ronald E., South, Vicki J., Davide, Joseph P., Kohl, Nancy E., Yan, Youwei, Kuo, Lawrence, Prueksaritanont, Thomayant, Li, Chunze, Mahan, Elizabeth A., Fernandez-Metzler, Carmen, Salata, Joseph J., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Nguyen, Diem N., Stump, Craig A., Walsh, Eileen S., Fernandes, Christine, Davide, Joseph P., Ellis-Hutchings, Michelle, Robinson, Ronald G., Williams, Theresa M., Lobell, Robert B., Huber, Hans E., Buser, Carolyn A.
Published in Bioorganic & medicinal chemistry letters (06.05.2002)
Published in Bioorganic & medicinal chemistry letters (06.05.2002)
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Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Dinsmore, Christopher J, Zartman, C.Blair, Bergman, Jeffrey M, Abrams, Marc T, Buser, Carolyn A, Culberson, J.Christopher, Davide, Joseph P, Ellis-Hutchings, Michelle, Fernandes, Christine, Graham, Samuel L, Hartman, George D, Huber, Hans E, Lobell, Robert B, Mosser, Scott D, Robinson, Ronald G, Williams, Theresa M
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I
Bergman, Jeffrey M, Abrams, Marc T, Davide, Joseph P, Greenberg, Ian B, Robinson, Ronald G, Buser, Carolyn A, Huber, Hans E, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Graham, Samuel L, Hartman, George D, Williams, Theresa M, Dinsmore, Christopher J
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
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Oxo-piperazine Derivatives of N-Arylpiperazinones as Inhibitors of Farnesyltransferase
Dinsmore, Christopher J, Bergman, Jeffrey M, Wei, Donna D, Zartman, C.Blair, Davide, Joseph P, Greenberg, Ian B, Liu, Dongming, O'Neill, Timothy J, Gibbs, Jackson B, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Chen, I-Wu, McLoughlin, Debra A, Olah, Timothy V, Graham, Samuel L, Hartman, George D, Williams, Theresa M
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
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