Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment
VanderVen, Brian C, Fahey, Ruth J, Lee, Wonsik, Liu, Yancheng, Abramovitch, Robert B, Memmott, Christine, Crowe, Adam M, Eltis, Lindsay D, Perola, Emanuele, Deininger, David D, Wang, Tiansheng, Locher, Christopher P, Russell, David G
Published in PLoS pathogens (01.02.2015)
Published in PLoS pathogens (01.02.2015)
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Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships
Charifson, Paul S, Grillot, Anne-Laure, Grossman, Trudy H, Parsons, Jonathan D, Badia, Michael, Bellon, Steve, Deininger, David D, Drumm, Joseph E, Gross, Christian H, LeTiran, Arnaud, Liao, Yusheng, Mani, Nagraj, Nicolau, David P, Perola, Emanuele, Ronkin, Steven, Shannon, Dean, Swenson, Lora L, Tang, Qing, Tessier, Pamela R, Tian, Ski-Kai, Trudeau, Martin, Wang, Tiansheng, Wei, Yunyi, Zhang, Hong, Stamos, Dean
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
Discovery of Potent, Selective Triazolothiadiazole-Containing c‑Met Inhibitors
Tang, Qing, Aronov, Alex M, Deininger, David D, Giroux, Simon, Lauffer, David J, Li, Pan, Liang, Jianglin, McGinty, Kira, Ronkin, Steven, Swett, Rebecca, Waal, Nathan, Boucher, Diane, Ford, Pamella J, Moody, Cameron S
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
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Journal Article
2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis
Clark, Michael P., Wang, Tiansheng, Perola, Emanuele, Deininger, David D., Zuccola, Harmon J., Jones, Steven M., Gao, Hong, VanderVen, Brian C., Russell, David G., Shoen, Carolyn M., Cynamon, Michael H., Thomson, John A., Locher, Christopher P.
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
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Journal Article
Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy
Perola, Emanuele, Stamos, Dean, Grillot, Anne-Laure, Ronkin, Steven, Wang, Tiansheng, LeTiran, Arnaud, Tang, Qing, Deininger, David D., Liao, Yusheng, Tian, Shi-Kai, Drumm, Joseph E., Nicolau, David P., Tessier, Pamela R., Mani, Nagraj, Grossman, Trudy H., Charifson, Paul S.
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
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Journal Article
Design and synthesis of novel conformationally restricted HIV protease inhibitors
Salituro, Francesco G., Baker, Christopher T., Court, John J., Deininger, David D., Kim, Eunice E., Li, Biquin, Novak, Perry M., Rao, Bhisetti G., Pazhanisamy, S., Porter, Margaret D., Schairer, Wayne C., Tung, Roger D.
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
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Journal Article
Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium's Metabolism Is Constrained by the Intracellular Environment: e1004679
VanderVen, Brian C, Fahey, Ruth J, Lee, Wonsik, Liu, Yancheng, Abramovitch, Robert B, Memmott, Christine, Crowe, Adam M, Eltis, Lindsay D, Perola, Emanuele, Deininger, David D, Wang, Tiansheng, Locher, Christopher P, Russell, David G
Published in PLoS pathogens (01.02.2015)
Published in PLoS pathogens (01.02.2015)
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Journal Article
New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin
Ocain, Timothy D, Deininger, David D, Russo, Ralph, Senko, Nancie A, Katz, Alan, Kitzen, Jan M, Mitchell, Robert, Oshiro, George, Russo, Anthony
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization
Perni, Robert B., Pitlik, Janos, Britt, Shawn D., Court, John J., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Levin, Rhonda B., Lin, Chao, Lin, Kai, Moon, Young-Choon, Luong, Yu-Ping, O'Malley, Ethan T., Rao, B.Govinda, Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Journal Article
Facile preparation of fused ring azolylureas
Drumm, Joseph E., Deininger, David D., LeTiran, Arnaud, Wang, Tiansheng, Grillot, Anne-Laure, Liao, Yusheng, Ronkin, Steven M., Stamos, Dean P., Tang, Qing, Tian, Shi-Kai, Oliver-Shaffer, Patricia
Published in Tetrahedron letters (30.07.2007)
Published in Tetrahedron letters (30.07.2007)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease 1. Non-Charged tetrapeptide variants
Perni, Robert B., Britt, Shawn D., Court, John C., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Kim, Joseph L., Landro, James A., Levin, Rhonda B., Luong, Yu-Ping, O'Malley, Ethan T., Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C., Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
Inhibitors of hepatitis C virus NS3.4A protease. Part 3: P2 proline variants
PERNI, Robert B, FARMER, Luc J, KAI LIN, LUONG, Yu-Ping, MAXWELL, John P, MURCKO, Mark A, PITLIK, Janos, GOVINDA RAO, B, SCHAIRER, Wayne C, TUNG, Roger D, VAN DRIE, John H, WILSON, Keith, COTTRELL, Kevin M, THOMSON, John A, COURT, John J, COURTNEY, Lawrence F, DEININGER, David D, GATES, Cynthia A, HARBESON, Scott L, KIM, Joseph L, CHAO LIN
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Journal Article
Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization
PERNI, Robert B, PITLIK, Janos, CHAO LIN, KAI LIN, MOON, Young-Choon, LUONG, Yu-Ping, O'MALLEY, Ethan T, GOVINDA RAO, B, THOMSON, John A, TUNG, Roger D, VAN DRIE, John H, YUNYI WEI, BRITT, Shawn D, COURT, John J, COURTNEY, Lawrence F, DEININGER, David D, FARMER, Luc J, GATES, Cynthia A, HARBESON, Scott L, LEVIN, Rhonda B
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Journal Article
Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants
PERNI, Robert B, BRITT, Shawn D, LEVIN, Rhonda B, LUONG, Yu-Ping, O'MALLEY, Ethan T, PITLIK, Janos, GOVINDA RAO, B, SCHAIRER, Wayne C, THOMSON, John A, TUNG, Roger D, VAN DRIE, John H, YUNYI WEI, COURT, John C, COURTNEY, Lawrence F, DEININGER, David D, FARMER, Luc J, GATES, Cynthia A, HARBESON, Scott L, KIM, Joseph L, LANDRO, James A
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Journal Article
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships
Charifson, Paul S, Grillot, Anne-Laure, Grossman, Trudy H, Parsons, Jonathan D, Badia, Michael, Bellon, Steve, Deininger, David D, Drumm, Joseph E, Gross, Christian H, LeTiran, Arnaud, Liao, Yusheng, Mani, Nagraj, Nicolau, David P, Perola, Emanuele, Ronkin, Steven, Shannon, Dean, Swenson, Lora L, Tang, Qing, Tessier, Pamela R, Tian, Ski-Kai, Trudeau, Martin, Wang, Tiansheng, Wei, Yunyi, Zhang, Hong, Stamos, Dean
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
INDOLE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD)
ZHANG, Hu, HALL, Amy B, COTTRELL, Kevin Michael, ZAKY, Mariam, BOYD, Michael John, FLEMING, Gabrielle Simone, FANNING, Lev T.D, DEININGER, David D, RONKIN, Steven M, WANG, Jian, JONES, Peter, SWETT, Rebecca Jane, ALLEN, Emily Elizabeth, NUHANT, Philippe Marcel, WAAL, Nathan D, COLLIER, Philip Noel, MAXWELL, Brad, BRODNEY, Michael Aaron, HURLEY, Dennis James, BOUCHER, Diane Marie, CLARK, Michael Philip, FIMOGNARI, Jr., Robert Francis, MAXWELL, John Patrick, DAMAGNEZ, Veronique, BANDARAGE, Upul Keerthi, JOHNSON, Jr., Mac Arthur, DENG, Hongbo, TAPLEY, Timothy Lewis, THOMSON, Stephen A, GIROUX, Simon, TANG, Qing
Year of Publication 25.05.2023
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Year of Publication 25.05.2023
Patent
INDOLE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD)
ZHANG, Hu, HALL, Amy B, COTTRELL, Kevin Michael, ZAKY, Mariam, BOYD, Michael John, FLEMING, Gabrielle Simone, FANNING, Lev T.D, DEININGER, David D, RONKIN, Steven M, JOHNSON, JR., Mac Arthur, WANG, Jian, JONES, Peter, SWETT, Rebecca Jane, ALLEN, Emily Elizabeth, NUHANT, Philippe Marcel, WAAL, Nathan D, COLLIER, Philip Noel, MAXWELL, Brad, BRODNEY, Michael Aaron, HURLEY, Dennis James, BOUCHER, Diane Marie, CLARK, Michael Philip, MAXWELL, John Patrick, FIMOGNARI, JR., Robert Francis, DAMAGNEZ, Veronique, BANDARAGE, Upul Keerthi, DENG, Hongbo, TAPLEY, Timothy Lewis, THOMSON, Stephen A, GIROUX, Simon, TANG, Qing
Year of Publication 15.02.2023
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Year of Publication 15.02.2023
Patent
Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (AATD)
ZHANG, Hu, HALL, Amy B, COTTRELL, Kevin Michael, ZAKY, Mariam, BOYD, Michael John, FLEMING, Gabrielle Simone, JOHNSON, JR, FANNING, Lev T.D, DEININGER, David D, RONKIN, Steven M, WANG, Jian, JONES, Peter, FIMOGNARI, JR, SWETT, Rebecca Jane, ALLEN, Emily Elizabeth, NUHANT, Philippe Marcel, WAAL, Nathan D, COLLIER, Philip Noel, MAXWELL, Brad, BRODNEY, Michael Aaron, HURLEY, Dennis James, BOUCHER, Diane Marie, CLARK, Michael Philip, MAXWELL, John Patrick, DAMAGNEZ, Veronique, BANDARAGE, Upul Keerthi, DENG, Hongbo, TAPLEY, Timothy Lewis, THOMSON, Stephen A, GIROUX, Simon, TANG, Qing
Year of Publication 03.11.2022
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Year of Publication 03.11.2022
Patent