Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling
Pantsar, Tatu, Rissanen, Sami, Dauch, Daniel, Laitinen, Tuomo, Vattulainen, Ilpo, Poso, Antti
Published in PLoS computational biology (01.09.2018)
Published in PLoS computational biology (01.09.2018)
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Journal Article
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models
Martinez-Quetglas, Iris, Pinyol, Roser, Dauch, Daniel, Torrecilla, Sara, Tovar, Victoria, Moeini, Agrin, Alsinet, Clara, Portela, Anna, Rodriguez-Carunchio, Leonardo, Solé, Manel, Lujambio, Amaia, Villanueva, Augusto, Thung, Swan, Esteller, Manel, Zender, Lars, Llovet, Josep M
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2016)
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Journal Article
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
Wang, Jianwei, Sun, Qian, Morita, Yohei, Jiang, Hong, Groß, Alexander, Lechel, André, Hildner, Kai, Guachalla, Luis Miguel, Gompf, Anne, Hartmann, Daniel, Schambach, Axel, Wuestefeld, Torsten, Dauch, Daniel, Schrezenmeier, Hubert, Hofmann, Wolf-Karsten, Nakauchi, Hiromitsu, Ju, Zhenyu, Kestler, Hans A., Zender, Lars, Rudolph, K. Lenhard
Published in Cell (02.03.2012)
Published in Cell (02.03.2012)
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Journal Article
A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas
Zender, Steffen, Nickeleit, Irina, Wuestefeld, Torsten, Sörensen, Inga, Dauch, Daniel, Bozko, Przemyslaw, El-Khatib, Mona, Geffers, Robert, Bektas, Hueseyin, Manns, Michael P., Gossler, Achim, Wilkens, Ludwig, Plentz, Ruben, Zender, Lars, Malek, Nisar P.
Published in Cancer cell (10.06.2013)
Published in Cancer cell (10.06.2013)
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Journal Article
Nucleoporin Nup155 is part of the p53 network in liver cancer
Holzer, Kerstin, Ori, Alessandro, Cooke, Amy, Dauch, Daniel, Drucker, Elisabeth, Riemenschneider, Philip, Andres-Pons, Amparo, DiGuilio, Amanda L., Mackmull, Marie-Therese, Baßler, Jochen, Roessler, Stephanie, Breuhahn, Kai, Zender, Lars, Glavy, Joseph S., Dombrowski, Frank, Hurt, Ed, Schirmacher, Peter, Beck, Martin, Singer, Stephan
Published in Nature communications (14.05.2019)
Published in Nature communications (14.05.2019)
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Journal Article
Prosurvival function of the cellular apoptosis susceptibility/importin‐α1 transport cycle is repressed by p53 in liver cancer
Winkler, Juliane, Ori, Alessandro, Holzer, Kerstin, Sticht, Carsten, Dauch, Daniel, Eiteneuer, Eva Maria, Pinna, Federico, Geffers, Robert, Ehemann, Volker, Andres‐Pons, Amparo, Breuhahn, Kai, Longerich, Thomas, Bermejo, Justo Lorenzo, Gretz, Norbert, Zender, Lars, Schirmacher, Peter, Beck, Martin, Singer, Stephan
Published in Hepatology (Baltimore, Md.) (01.09.2014)
Published in Hepatology (Baltimore, Md.) (01.09.2014)
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Journal Article
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
Wang, Jianwei, Sun, Qian, Morita, Yohei, Jiang, Hong, Groß, Alexander, Lechel, André, Hildner, Kai, Guachalla, Luis Miguel, Gompf, Anne, Hartmann, Daniel, Schambach, Axel, Wüstefeld, Torsten, Dauch, Daniel, Schrezenmeier, Hubert, Hofmann, Wolf-Karsten, Nakauchi, Hiromitsu, Ju, Zhenyu, Kestler, Hans A, Zender, Lars, Rudolph, K Lenhard
Published in Cell (11.09.2014)
Published in Cell (11.09.2014)
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Journal Article
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, Tae-Won, Yevsa, Tetyana, Woller, Norman, Hoenicke, Lisa, Wuestefeld, Torsten, Dauch, Daniel, Hohmeyer, Anja, Gereke, Marcus, Rudalska, Ramona, Potapova, Anna, Iken, Marcus, Vucur, Mihael, Weiss, Siegfried, Heikenwalder, Mathias, Khan, Sadaf, Gil, Jesus, Bruder, Dunja, Manns, Michael, Schirmacher, Peter, Tacke, Frank, Ott, Michael, Luedde, Tom, Longerich, Thomas, Kubicka, Stefan, Zender, Lars
Published in Nature (London) (24.11.2011)
Published in Nature (London) (24.11.2011)
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Journal Article
A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer
Dauch, Daniel, Rudalska, Ramona, Cossa, Giacomo, Nault, Jean-Charles, Kang, Tae-Won, Wuestefeld, Torsten, Hohmeyer, Anja, Imbeaud, Sandrine, Yevsa, Tetyana, Hoenicke, Lisa, Pantsar, Tatu, Bozko, Przemyslaw, Malek, Nisar P, Longerich, Thomas, Laufer, Stefan, Poso, Antti, Zucman-Rossi, Jessica, Eilers, Martin, Zender, Lars
Published in Nature medicine (01.07.2016)
Published in Nature medicine (01.07.2016)
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Journal Article
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
Rudalska, Ramona, Dauch, Daniel, Longerich, Thomas, McJunkin, Katherine, Wuestefeld, Torsten, Kang, Tae-Won, Hohmeyer, Anja, Pesic, Marina, Leibold, Josef, von Thun, Anne, Schirmacher, Peter, Zuber, Johannes, Weiss, Karl-Heinz, Powers, Scott, Malek, Nisar P, Eilers, Martin, Sipos, Bence, Lowe, Scott W, Geffers, Robert, Laufer, Stefan, Zender, Lars
Published in Nature medicine (01.10.2014)
Published in Nature medicine (01.10.2014)
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Journal Article
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles
Schwarz, Moritz, Kurkunov, Maksym, Wittlinger, Florian, Rudalska, Ramona, Wang, Guiqun, Schwalm, Martin Peter, Rasch, Alexander, Wagner, Benedikt, Laufer, Stefan A., Knapp, Stefan, Dauch, Daniel, Gehringer, Matthias
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
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Journal Article
Cardiac glycosides are broad-spectrum senolytics
Guerrero, Ana, Herranz, Nicolás, Sun, Bin, Wagner, Verena, Gallage, Suchira, Guiho, Romain, Wolter, Katharina, Pombo, Joaquim, Irvine, Elaine E, Innes, Andrew J, Birch, Jodie, Glegola, Justyna, Manshaei, Saba, Heide, Danijela, Dharmalingam, Gopuraja, Harbig, Jule, Olona, Antoni, Behmoaras, Jacques, Dauch, Daniel, Uren, Anthony G, Zender, Lars, Vernia, Santiago, Martínez-Barbera, Juan Pedro, Heikenwalder, Mathias, Withers, Dominic J, Gil, Jesús
Published in Nature metabolism (01.11.2019)
Published in Nature metabolism (01.11.2019)
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Journal Article
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S N Ar Electrophiles
Schwarz, Moritz, Kurkunov, Maksym, Wittlinger, Florian, Rudalska, Ramona, Wang, Guiqun, Schwalm, Martin Peter, Rasch, Alexander, Wagner, Benedikt, Laufer, Stefan A, Knapp, Stefan, Dauch, Daniel, Gehringer, Matthias
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
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Journal Article
Design and Optimization of Novel Benzimidazole- and Imidazo[4,5‑b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities
Dimitrov, Teodor, Moschopoulou, Athina Anastasia, Seidel, Lennart, Kronenberger, Thales, Kudolo, Mark, Poso, Antti, Geibel, Christian, Wölffing, Pascal, Dauch, Daniel, Zender, Lars, Schollmeyer, Dieter, Bajorath, Jürgen, Forster, Michael, Laufer, Stefan
Published in Journal of medicinal chemistry (08.06.2023)
Published in Journal of medicinal chemistry (08.06.2023)
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Journal Article
Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC)
Buczak, Katarzyna, Ori, Alessandro, Kirkpatrick, Joanna M., Holzer, Kerstin, Dauch, Daniel, Roessler, Stephanie, Endris, Volker, Lasitschka, Felix, Parca, Luca, Schmidt, Alexander, Zender, Lars, Schirmacher, Peter, Krijgsveld, Jeroen, Singer, Stephan, Beck, Martin
Published in Molecular & cellular proteomics (01.04.2018)
Published in Molecular & cellular proteomics (01.04.2018)
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Journal Article
MYC determines lineage commitment in KRAS-driven primary liver cancer development
D’Artista, Luana, Moschopoulou, Athina Anastasia, Barozzi, Iros, Craig, Amanda J., Seehawer, Marco, Herrmann, Lea, Minnich, Martina, Kang, Tae-Won, Rist, Elke, Henning, Melanie, Klotz, Sabrina, Heinzmann, Florian, Harbig, Jule, Sipos, Bence, Longerich, Thomas, Eilers, Martin, Dauch, Daniel, Zuber, Johannes, Wang, Xin Wei, Zender, Lars
Published in Journal of hepatology (01.07.2023)
Published in Journal of hepatology (01.07.2023)
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Journal Article
Abstract 3063: Defining oncogene-specific metabolic vulnerabilities in a mouse model of hepatocellular carcinoma
Al-Shami, Kamal, Snaebjornsson, Marteinn, Vogel, Felix, Schlicker, Lisa, Pöller, Phillip, Dauch, Daniel, Schulze, Almut
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration
Wuestefeld, Torsten, Pesic, Marina, Rudalska, Ramona, Dauch, Daniel, Longerich, Thomas, Kang, Tae-Won, Yevsa, Tetyana, Heinzmann, Florian, Hoenicke, Lisa, Hohmeyer, Anja, Potapova, Anna, Rittelmeier, Ina, Jarek, Michael, Geffers, Robert, Scharfe, Maren, Klawonn, Frank, Schirmacher, Peter, Malek, Nisar P., Ott, Michael, Nordheim, Alfred, Vogel, Arndt, Manns, Michael P., Zender, Lars
Published in Cell (11.04.2013)
Published in Cell (11.04.2013)
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Journal Article
Selective targeting of the αC and DFG-out pocket in p38 MAPK
Röhm, Sandra, Schröder, Martin, Dwyer, Jessica E., Widdowson, Caroline S., Chaikuad, Apirat, Berger, Benedict-Tilman, Joerger, Andreas C., Krämer, Andreas, Harbig, Jule, Dauch, Daniel, Kudolo, Mark, Laufer, Stefan, Bagley, Mark C., Knapp, Stefan
Published in European journal of medicinal chemistry (15.12.2020)
Published in European journal of medicinal chemistry (15.12.2020)
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