Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain
Dzierba, Carolyn D., Dasgupta, Bireshwar, Karageorge, George, Kostich, Walter, Hamman, Brian, Allen, Jason, Esposito, Kim M., Padmanabha, Ramesh, Grace, James, Lentz, Kimberley, Morrison, John, Morgan, Daniel, Easton, Amy, Bourin, Clotilde, Browning, Marc R., Rajamani, Ramkumar, Good, Andrew, Parker, Dawn D., Muckelbauer, Jodi K., Khan, Javed, Camac, Daniel, Ghosh, Kaushik, Halan, Vivek, Lippy, Jonathan S., Santone, Kenneth S., Denton, R. Rex, Westphal, Ryan, Bristow, Linda J., Conway, Charles M., Bronson, Joanne J., Macor, John E.
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88
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Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2‑Associated Kinase 1 Inhibitors
Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C. M. Vijaya, Manepalli, Raju K. V. L. P, Sarvasiddhi, Sarat Kumar, Honkhambe, Swarnamba, Patankar, Vidya, Dasgupta, Bireshwar, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel M, Ghosh, Kaushik, Pokross, Matthew, Kiefer, Susan E, Brown, Jeffrey M, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Lippy, Jonathan S, Surti, Neha, Hamman, Brian D, Allen, Jason, Kostich, Walter A, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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QIN JIM, KUGLER DAVID G, OLSON RICHARD, MAIER ALISON, ROY SAUMYA, GRUNENFELDER DENISE CHRISTINE, SIVAKUMAR PALLAVUR, VELAPARTHI UPENDER, WARRIER JAYAKUMAR SANKARA, DARNE CHETAN PADMAKAR, DASGUPTA BIRESHWAR, JALAGAM PRASADA RAO, RAHAMAN HASIBUR, WICHROSKI MICHAEL
Year of Publication 05.12.2023
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Year of Publication 05.12.2023
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T 세포 활성화제로서 유용한 치환된 피리도피리미디노닐 화합물
WARRIER JAYAKUMAR SANKARA, GRUNENFELDER DENISE C, DARNE CHETAN PADMAKAR, DASGUPTA BIRESHWAR, ROY SAUMYA, JALAGAM PRASADA RAO, RAHAMAN HASIBUR, OLSON RICHARD E, VELAPARTHI UPENDER
Year of Publication 28.04.2022
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Year of Publication 28.04.2022
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DEGNAN ANDREW P, ZHANG GUIFEN, ARAUJO ERIKA M. V, DASGUPTA BIRESHWAR, CHEN YAN, HILL MATTHEW D, KUMI GODWIN KWAME, WITTMAN MARK D, PEARCE BRADLEY C, MASTALERZ HAROLD A
Year of Publication 14.07.2020
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Year of Publication 14.07.2020
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DGK 억제제 및 체크포인트 길항제의 조합물
DING MIN, TOKARSKI JOHN S, ROY SAUMYA, KAMBLE MANJUNATHA NARAYANA RAO, VELAPARTHI UPENDER, GRUNENFELDER DENISE, ZHENG XIAOFAN, RAJA THIRUVENKADAM, JALAGAM PRASADA RAO, BENCI JOSEPH L, OLSON RICHARD E, CHUPAK LOUIS S, REDDY KOTHA RATHNAKAR, WEE SUSAN, DARNE CHETAN P, WANG XINYU, TONUKUNURU GOPIKISHAN, WARRIER JAYAKUMAR SANKARA, MARTIN SCOTT W, WICHROSKI MICHAEL J, MCDONALD IVAR M, DASGUPTA BIRESHWAR, MANNOORI RAJU, RAHAMAN HASIBUR, VELAIAH SIVASUDAR, GENTLES ROBERT G, HUANG YAZHONG
Year of Publication 25.08.2022
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Year of Publication 25.08.2022
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Serendipitous oxidation product of BIBN4096BS: A potent CGRP receptor antagonist
Dasgupta, Bireshwar, Kozlowski, Edward, Schroeder, Daniel R., Torrente, John R., Xu, Cen, Pin, Sokhom, Conway, Charlie M., Dubowchik, Gene M., Macor, John E., Vrudhula, Vivekananda M.
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
Published in Bioorganic & medicinal chemistry letters (15.06.2014)
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T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물
DING MIN, CHUPAK LOUIS S, TOKARSKI JOHN S, REDDY KOTHA RATHNAKAR, ROY SAUMYA, TONUKUNURU GOPIKISHAN, KAMBLE MANJUNATHA NARAYANA RAO, VELAPARTHI UPENDER, WARRIER JAYAKUMAR SANKARA, DARNE CHETAN PADMAKAR, MARTIN SCOTT W, MCDONALD IVAR M, ZHENG XIAOFAN, DASGUPTA BIRESHWAR, MANNOORI RAJU, RAJA THIRUVENKADAM, JALAGAM PRASADA RAO, RAHAMAN HASIBUR, VELAIAH SIVASUDAR, GENTLES ROBERT G, OLSON RICHARD E, HUANG YAZHONG
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Year of Publication 05.03.2021
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An Efficient, Direct Bis-ortho-chlorination of 4-(Difluoromethoxy)aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist
Li, Jianqing, Smith, Daniel, Krishnananthan, Subramaniam, Hartz, Richard A, Dasgupta, Bireshwar, Ahuja, Vijay, Schmitz, William D, Bronson, Joanne J, Mathur, Arvind, Barrish, Joel C, Chen, Bang-Chi
Published in Organic process research & development (20.01.2012)
Published in Organic process research & development (20.01.2012)
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Separation of maxi-K channel opening 3-substitued-4-arylquinolinone atropisomers by enantioselective supercritical fluid chromatography
Qian-Cutrone, Jingfang, Dasgupta, Bireshwar, Kozlowski, Edward S., Dalterio, Richard, Wang-Iverson, David, Vrudhula, Vivekananda M.
Published in Journal of pharmaceutical and biomedical analysis (01.12.2008)
Published in Journal of pharmaceutical and biomedical analysis (01.12.2008)
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Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists
Dzierba, Carolyn D., Sielecki, Thais M., Arvanitis, Argyrios G., Galka, Amy, Johnson, Tricia L., Takvorian, Amy G., Rafalski, Maria, Kasireddy-Polam, Padmaja, Vig, Shikha, Dasgupta, Bireshwar, Zhang, Ge, Molski, Thaddeus F., Wong, Harvey, Zaczek, Robert C., Lodge, Nicholas J., Combs, Andrew P., Gilligan, Paul J., Trainor, George L., Bronson, Joanne J., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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Separation of maxi-K channel opening 3-substituted-4-arylquinolinone atropisomers by enantioselective supercritical fluid chromatography
Qian-Cutrone, Jingfang, Dasgupta, Bireshwar, Kozlowski, Edward S, Dalterio, Richard, Wang-Iverson, David, Vrudhula, Vivekananda M
Published in Journal of pharmaceutical and biomedical analysis (01.12.2008)
Published in Journal of pharmaceutical and biomedical analysis (01.12.2008)
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2-Aryl-2,2-difluoroacetamide FKBP12 Ligands: Synthesis and X-ray Structural Studies
Dubowchik, Gene M, Vrudhula, Vivekananda M, Dasgupta, Bireshwar, Ditta, Jonathan, Chen, Ti, Sheriff, Steven, Sipman, Karin, Witmer, Mark, Tredup, Jeffrey, Vyas, Dolatrai M, Verdoorn, Todd A, Bollini, Sagarika, Vinitsky, Alexander
Published in Organic letters (13.12.2001)
Published in Organic letters (13.12.2001)
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Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists
Zuev, Dmitry, Vrudhula, Vivekananda M., Michne, Jodi A., Dasgupta, Bireshwar, Pin, Sokhom S., Huang, Xiaohua Stella, Wu, Dedong, Gao, Qi, Zhang, Jie, Taber, Matthew T., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF sub(1)R)
Vrudhula, Vivekananda M, Dasgupta, Bireshwar, Pin, Sokhom S, Burris, Kevin D, Balanda, Lynn A, Fung, Lawrence K, Fiedler, Tracey, Browman, Kaitlin E, Taber, Matthew T, Zhang, Jie, Macor, John E, Dubowchik, Gene M
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Journal Article
Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF 1R)
Vrudhula, Vivekananda M., Dasgupta, Bireshwar, Pin, Sokhom S., Burris, Kevin D., Balanda, Lynn A., Fung, Lawrence K., Fiedler, Tracey, Browman, Kaitlin E., Taber, Matthew T., Zhang, Jie, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Journal Article
Atropisomeric 3-(β-hydroxyethyl)-4-arylquinolin-2-ones as Maxi-K Potassium Channel Openers
Vrudhula, Vivekananda M, Dasgupta, Bireshwar, Qian-Cutrone, Jingfang, Kozlowski, Edward S, Boissard, Christopher G, Dworetzky, Steven I, Wu, Dedong, Gao, Qi, Kimura, Roy, Gribkoff, Valentin K, Starrett, John E
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
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