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Bhatt, Aadra P., Pellock, Samuel J., Biernat, Kristen A., Walton, William G., Wallace, Bret D., Creekmore, Benjamin C., Letertre, Marine M., Swann, Jonathan R., Wilson, Ian D., Roques, Jose R., Darr, David B., Bailey, Sean T., Montgomery, Stephanie A., Roach, Jeffrey M., Azcarate-Peril, M. Andrea, Sartor, R. Balfour, Gharaibeh, Raad Z., Bultman, Scott J., Redinbo, Matthew R.
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2020)
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Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer
Alwarawrah, Yazan, Hughes, Philip, Loiselle, David, Carlson, David A., Darr, David B., Jordan, Jamie L., Xiong, Jessie, Hunter, Lucas M., Dubois, Laura G., Thompson, J. Will, Kulkarni, Manjusha M., Ratcliff, Annette N., Kwiek, Jesse J., Haystead, Timothy A.J.
Published in Cell chemical biology (23.06.2016)
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A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity
He, Zhijian, Wan, Xiaomeng, Schulz, Anita, Bludau, Herdis, Dobrovolskaia, Marina A, Stern, Stephan T, Montgomery, Stephanie A, Yuan, Hong, Li, Zibo, Alakhova, Daria, Sokolsky, Marina, Darr, David B, Perou, Charles M, Jordan, Rainer, Luxenhofer, Robert, Kabanov, Alexander V
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Duncan, James S., Whittle, Martin C., Nakamura, Kazuhiro, Abell, Amy N., Midland, Alicia A., Zawistowski, Jon S., Johnson, Nancy L., Granger, Deborah A., Jordan, Nicole Vincent, Darr, David B., Usary, Jerry, Kuan, Pei-Fen, Smalley, David M., Major, Ben, He, Xiaping, Hoadley, Katherine A., Zhou, Bing, Sharpless, Norman E., Perou, Charles M., Kim, William Y., Gomez, Shawn M., Chen, Xin, Jin, Jian, Frye, Stephen V., Earp, H. Shelton, Graves, Lee M., Johnson, Gary L.
Published in Cell (13.04.2012)
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Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model
Burd, Christin E, Sorrentino, Jessica A, Clark, Kelly S, Darr, David B, Krishnamurthy, Janakiraman, Deal, Allison M, Bardeesy, Nabeel, Castrillon, Diego H, Beach, David H, Sharpless, Norman E
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Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling
Chandler, Ronald L., Damrauer, Jeffrey S., Raab, Jesse R., Schisler, Jonathan C., Wilkerson, Matthew D., Didion, John P., Starmer, Joshua, Serber, Daniel, Yee, Della, Xiong, Jessie, Darr, David B., de Villena, Fernando Pardo-Manuel, Kim, William Y., Magnuson, Terry
Published in Nature communications (27.01.2015)
Published in Nature communications (27.01.2015)
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Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy
ROBERTS, Patrick J, BISI, John E, STRUM, Jay C, COMBEST, Austin J, DARR, David B, USARY, Jerry E, ZAMBONI, William C, WONG, Kwok-Kin, PEROU, Charles M, SHARPLESS, Norman E
Published in JNCI : Journal of the National Cancer Institute (21.03.2012)
Published in JNCI : Journal of the National Cancer Institute (21.03.2012)
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New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging
Brighton, Hailey E, Angus, Steven P, Bo, Tao, Roques, Jose, Tagliatela, Alicia C, Darr, David B, Karagoz, Kubra, Sciaky, Noah, Gatza, Michael L, Sharpless, Norman E, Johnson, Gary L, Bear, James E
Published in Cancer research (Chicago, Ill.) (15.01.2018)
Published in Cancer research (Chicago, Ill.) (15.01.2018)
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Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation
He, Zhijian, Schulz, Anita, Wan, Xiaomeng, Seitz, Joshua, Bludau, Herdis, Alakhova, Daria Y., Darr, David B., Perou, Charles M., Jordan, Rainer, Ojima, Iwao, Kabanov, Alexander V., Luxenhofer, Robert
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Published in Journal of controlled release (28.06.2015)
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A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer
Cheng, Ning, Watkins-Schulz, Rebekah, Junkins, Robert D, David, Clément N, Johnson, Brandon M, Montgomery, Stephanie A, Peine, Kevin J, Darr, David B, Yuan, Hong, McKinnon, Karen P, Liu, Qi, Miao, Lei, Huang, Leaf, Bachelder, Eric M, Ainslie, Kristy M, Ting, Jenny P-Y
Published in JCI insight (15.11.2018)
Published in JCI insight (15.11.2018)
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Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma
Burd, Christin E, Liu, Wenjin, Huynh, Minh V, Waqas, Meriam A, Gillahan, James E, Clark, Kelly S, Fu, Kailing, Martin, Brit L, Jeck, William R, Souroullas, George P, Darr, David B, Zedek, Daniel C, Miley, Michael J, Baguley, Bruce C, Campbell, Sharon L, Sharpless, Norman E
Published in Cancer discovery (01.12.2014)
Published in Cancer discovery (01.12.2014)
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Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex
Zawistowski, Jon S, Bevill, Samantha M, Goulet, Daniel R, Stuhlmiller, Timothy J, Beltran, Adriana S, Olivares-Quintero, Jose F, Singh, Darshan, Sciaky, Noah, Parker, Joel S, Rashid, Naim U, Chen, Xin, Duncan, James S, Whittle, Martin C, Angus, Steven P, Velarde, Sara Hanna, Golitz, Brian T, He, Xiaping, Santos, Charlene, Darr, David B, Gallagher, Kristalyn, Graves, Lee M, Perou, Charles M, Carey, Lisa A, Earp, H Shelton, Johnson, Gary L
Published in Cancer discovery (01.03.2017)
Published in Cancer discovery (01.03.2017)
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Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer
Bowerman, Charles J, Byrne, James D, Chu, Kevin S, Schorzman, Allison N, Keeler, Amanda W, Sherwood, Candice A, Perry, Jillian L, Luft, James C, Darr, David B, Deal, Allison M, Napier, Mary E, Zamboni, William C, Sharpless, Norman E, Perou, Charles M, DeSimone, Joseph M
Published in Nano letters (11.01.2017)
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Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research
Sigmon, John Sebastian, Blanchard, Matthew W, Baric, Ralph S, Bell, Timothy A, Brennan, Jennifer, Brockmann, Gudrun A, Burks, A Wesley, Calabrese, J Mauro, Caron, Kathleen M, Cheney, Richard E, Ciavatta, Dominic, Conlon, Frank, Darr, David B, Faber, James, Franklin, Craig, Gershon, Timothy R, Gralinski, Lisa, Gu, Bin, Gaines, Christiann H, Hagan, Robert S, Heimsath, Ernest G, Heise, Mark T, Hock, Pablo, Ideraabdullah, Folami, Jennette, J Charles, Kafri, Tal, Kashfeen, Anwica, Kulis, Mike, Kumar, Vivek, Linnertz, Colton, Livraghi-Butrico, Alessandra, Lloyd, K C Kent, Lutz, Cathleen, Lynch, Rachel M, Magnuson, Terry, Matsushima, Glenn K, McMullan, Rachel, Miller, Darla R, Mohlke, Karen L, Moy, Sheryl S, Murphy, Caroline E Y, Najarian, Maya, O’Brien, Lori, Palmer, Abraham A, Philpot, Benjamin D, Randell, Scott H, Reinholdt, Laura, Ren, Yuyu, Rockwood, Steve, Rogala, Allison R, Saraswatula, Avani, Sassetti, Christopher M, Schisler, Jonathan C, Schoenrock, Sarah A, Shaw, Ginger D, Shorter, John R, Smith, Clare M, St. Pierre, Celine L, Tarantino, Lisa M, Threadgill, David W, Valdar, William, Vilen, Barbara J, Wardwell, Keegan, Whitmire, Jason K, Williams, Lucy, Zylka, Mark J, Ferris, Martin T, McMillan, Leonard, Manuel de Villena, Fernando Pardo
Published in Genetics (Austin) (01.12.2020)
Published in Genetics (Austin) (01.12.2020)
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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies
Tarpley, Michael, Oladapo, Helen O., Strepay, Dillon, Caligan, Thomas B., Chdid, Lhoucine, Shehata, Hassan, Roques, Jose R., Thomas, Rhashad, Laudeman, Christopher P., Onyenwoke, Rob U., Darr, David B., Williams, Kevin P.
Published in European journal of pharmaceutical sciences (01.07.2021)
Published in European journal of pharmaceutical sciences (01.07.2021)
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Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models
Song, Gina, Darr, David B, Santos, Charlene M, Ross, Mark, Valdivia, Alain, Jordan, Jamie L, Midkiff, Bentley R, Cohen, Stephanie, Nikolaishvili-Feinberg, Nana, Miller, C Ryan, Tarrant, Teresa K, Rogers, Arlin B, Dudley, Andrew C, Perou, Charles M, Zamboni, William C
Published in Clinical cancer research (01.12.2014)
Published in Clinical cancer research (01.12.2014)
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Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
Herschkowitz, Jason I, Zhao, Wei, Zhang, Mei, Usary, Jerry, Murrow, George, Edwards, David, Knezevic, Jana, Greene, Stephanie B, Darr, David, Troester, Melissa A, Hilsenbeck, Susan G, Medina, Daniel, Perou, Charles M, Rosen, Jeffrey M
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models
ROBERT, Patrick J, USARY, Jerry E, ZAMBONI, William C, JOHNSON, Gary L, PEROU, Charles M, SHARPLESS, Norman E, DARR, David B, DILLON, Patrick M, PFEFFERLE, Adam D, WHITTLE, Martin C, DUNCAN, James S, JOHNSON, Soren M, COMBEST, Austin J, JIAN JIN
Published in Clinical cancer research (01.10.2012)
Published in Clinical cancer research (01.10.2012)
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Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice
Sundaram, Sneha, Freemerman, Alex J, Galanko, Joseph A, McNaughton, Kirk K, Bendt, Katharine M, Darr, David B, Troester, Melissa A, Makowski, Liza
Published in PloS one (29.10.2014)
Published in PloS one (29.10.2014)
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Potential Vorticity Dynamics of Tropical Instability Vortices
HOLMES, Ryan M, THOMAS, Leif N, THOMPSON, LuAnne, DARR, David
Published in Journal of physical oceanography (01.03.2014)
Published in Journal of physical oceanography (01.03.2014)
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