Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
Stepan, Antonia F, Walker, Daniel P, Bauman, Jonathan, Price, David A, Baillie, Thomas A, Kalgutkar, Amit S, Aleo, Michael D
Published in Chemical research in toxicology (19.09.2011)
Published in Chemical research in toxicology (19.09.2011)
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Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design
Han, Seungil, Mistry, Anil, Chang, Jeanne S., Cunningham, David, Griffor, Matt, Bonnette, Peter C., Wang, Hong, Chrunyk, Boris A., Aspnes, Gary E., Walker, Daniel P., Brosius, Arthur D., Buckbinder, Leonard
Published in The Journal of biological chemistry (08.05.2009)
Published in The Journal of biological chemistry (08.05.2009)
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Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation
Arhancet, Graciela B., Walker, Daniel P., Metz, Sue, Fobian, Yvette M., Heasley, Steven E., Carter, Jeffrey S., Springer, John R., Jones, Darin E., Hayes, Michael J., Shaffer, Alexander F., Jerome, Gina M., Baratta, Michael T., Zweifel, Ben, Moore, William M., Masferrer, Jaime L., Vazquez, Michael L.
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
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Ocular hazards of blue-light therapy in dermatology
Walker, Daniel P., BS, Vollmer-Snarr, Heidi R., PhD, Eberting, Cheryl Lee D., MD
Published in Journal of the American Academy of Dermatology (01.01.2012)
Published in Journal of the American Academy of Dermatology (01.01.2012)
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Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide
Boyer, David, Bauman, Jonathan N, Walker, Daniel P, Kapinos, Brendon, Karki, Kapil, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.05.2009)
Published in Drug metabolism and disposition (01.05.2009)
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Novel riboswitch-binding flavin analog that protects mice against Clostridium difficile infection without inhibiting cecal flora
Blount, Kenneth F, Megyola, Cynthia, Plummer, Mark, Osterman, David, O'Connell, Tim, Aristoff, Paul, Quinn, Cheryl, Chrusciel, R Alan, Poel, Toni J, Schostarez, Heinrich J, Stewart, Catherine A, Walker, Daniel P, Wuts, Peter G M, Breaker, Ronald R
Published in Antimicrobial agents and chemotherapy (01.09.2015)
Published in Antimicrobial agents and chemotherapy (01.09.2015)
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Determination of Cotton as a Larval Feeding Source for Lepidopteran Moths Using a Derivative from Cotton Metabolites as a Marker by LC-MS/MS Method
Kim, Jae Hak, Lagojda, Andreas, Kuehne, Dirk, Tshitenge, Dieudonné Tshitenge, Chaudhuri, Swapan, Walker, Daniel P., Head, Graham
Published in Journal of chemical ecology (01.10.2020)
Published in Journal of chemical ecology (01.10.2020)
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Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor: SAR Investigation Around PNU-120596
Acker, Brad A, Badescu, Valentina O, Berkenpas, Mitchell B, Groppi, Vincent E, Hajós, Mihaly, Higdon, Nicole R, Hurst, Raymond S, Jon Jacobsen, E, Margolis, Brandon J, McWhorter, William W, Myers, Jason K, Piotrowski, David W, Rogers, Bruce N, Sarapa, Dusan, Vetman, Tatiana N, Walker, Daniel P, Wall, Theron M, Wilhite, David M, Wishka, Donn G, Xu, Wenjian, Yates, Karen M
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
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Discovery and Preclinical Characterization of 1‑Methyl‑3-(4‑methylpyridin‑3‑yl)‑6‑(pyridin‑2‑ylmethoxy)‑1H‑pyrazolo-[3,4‑b]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator
Zhang, Lei, Balan, Gayatri, Barreiro, Gabriela, Boscoe, Brian P, Chenard, Lois K, Cianfrogna, Julie, Claffey, Michelle M, Chen, Laigao, Coffman, Karen J, Drozda, Susan E, Dunetz, Joshua R, Fonseca, Kari R, Galatsis, Paul, Grimwood, Sarah, Lazzaro, John T, Mancuso, Jessica Y, Miller, Emily L, Reese, Matthew R, Rogers, Bruce N, Sakurada, Isao, Skaddan, Marc, Smith, Deborah L, Stepan, Antonia F, Trapa, Patrick, Tuttle, Jamison B, Verhoest, Patrick R, Walker, Daniel P, Wright, Ann S, Zaleska, Margaret M, Zasadny, Kenneth, Shaffer, Christopher L
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E. Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H. F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Discovery and Characterization of (R)‑6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1‑c][1,4]oxazin-4(9H)‑one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Stepan, Antonia F, Claffey, Michelle M, Reese, Matthew R, Balan, Gayatri, Barreiro, Gabriela, Barricklow, Jason, Bohanon, Michael J, Boscoe, Brian P, Cappon, Gregg D, Chenard, Lois K, Cianfrogna, Julie, Chen, Laigao, Coffman, Karen J, Drozda, Susan E, Dunetz, Joshua R, Ghosh, Somraj, Hou, Xinjun, Houle, Christopher, Karki, Kapil, Lazzaro, John T, Mancuso, Jessica Y, Marcek, John M, Miller, Emily L, Moen, Mark A, O’Neil, Steven, Sakurada, Isao, Skaddan, Marc, Parikh, Vinod, Smith, Deborah L, Trapa, Patrick, Tuttle, Jamison B, Verhoest, Patrick R, Walker, Daniel P, Won, Annie, Wright, Ann S, Whritenour, Jessica, Zasadny, Kenneth, Zaleska, Margaret M, Zhang, Lei, Shaffer, Christopher L
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity
Walker, Daniel P., Zawistoski, Michael P., McGlynn, Molly A., Li, Jian-Cheng, Kung, Daniel W., Bonnette, Peter C., Baumann, Amy, Buckbinder, Leonard, Houser, Janet A., Boer, Jason, Mistry, Anil, Han, Seungil, Guzman-Perez, Li Xing and Angel
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
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Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design
Walker, Daniel P., Arhancet, Graciela B., Lu, Hwang-Fun, Heasley, Steven E., Metz, Sue, Kablaoui, Natasha M., Franco, Francisco M., Hanau, Cathleen E., Scholten, Jeffrey A., Springer, John R., Fobian, Yvette M., Carter, Jeffrey S., Xing, Li, Yang, Shengtian, Shaffer, Alexander F., Jerome, Gina M., Baratta, Michael T., Moore, William M., Vazquez, Michael L.
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
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A Concise Synthesis of 6-Oxa-3-azabicyclo[3.1.1]heptane Hydrotosylate
Wishka, Donn G., Beagley, Paul, Lyon, Jessica, Farley, Kathleen A., Walker, Daniel P.
Published in Synthesis (Stuttgart) (01.08.2011)
Published in Synthesis (Stuttgart) (01.08.2011)
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Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the alpha 7 nicotinic acetylcholine receptor: In vitro and in vivo activity
Acker, Brad A, Jacobsen, EJon, Rogers, Bruce N, Wishka, Donn G, Reitz, Steven C, Piotrowski, David W, Myers, Jason K, Wolfe, Mark L, Groppi, Vincent E, Thornburgh, Bruce A, Tinholt, Paula M, Walters, Rodney R, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Krause, Michael, Li, Kai S, Hoffmann, William E, Hajos, Mihaly, Hurst, Raymond S, Walker, Daniel P
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Synthesis of (+/-)-8-Oxa-3-azabicyclo[3.2.1]octan-2-thione and (+/-)-2-Oxa-5-azabicyclo[2.2.1]heptan-6-thione: Potential Synthons for the Preparation of Novel Heteroaryl-Annulated Bicyclic Morpholines
Walker, Daniel P., Wishka, Donn G., Beagley, Paul, Turner, Gemma, Solesbury, Nicola
Published in Synthesis (Stuttgart) (01.04.2011)
Published in Synthesis (Stuttgart) (01.04.2011)
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Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha 7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, EJon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik HF, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
Published in Bioorganic & medicinal chemistry (15.12.2006)
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Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2) : Structure-activity relationships and strategies for the elimination of reactive metabolite formation
WALKER, Daniel P, BI, F. Christopher, MCGLYNN, Molly A, OLIVER, Robert, DUNN, Matthew, LI, Jian-Cheng, RICHTER, Daniel T, COOPER, Beth A, KATH, John C, HULFORD, Catherine A, AUTRY, Christopher L, LUZZIO, Michael J, KALGUTKAR, Amit S, UNG, Ethan J, ROBERTS, W. Gregory, BONNETTE, Peter C, BUCKBINDER, Leonard, MISTRY, Anil, GRIFFOR, Matthew C, HAN, Seungil, GUZMAN-PEREZ, Angel, BAUMAN, Jonathan N, ZHAO, Sabrina X, SOGLIA, John R, ASPNES, Gary E, KUNG, Daniel W, KLUG-MCLEOD, Jacquelyn, ZAWISTOSKI, Michael P
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
Bhattacharya, Samit K., Aspnes, Gary E., Bagley, Scott W., Boehm, Markus, Brosius, Arthur D., Buckbinder, Leonard, Chang, Jeanne S., Dibrino, Joseph, Eng, Heather, Frederick, Kosea S., Griffith, David A., Griffor, Matthew C., Guimarães, Cristiano R.W., Guzman-Perez, Angel, Han, Seungil, Kalgutkar, Amit S., Klug-McLeod, Jacquelyn, Garcia-Irizarry, Carmen, Li, Jianke, Lippa, Blaise, Price, David A., Southers, James A., Walker, Daniel P., Wei, Liuqing, Xiao, Jun, Zawistoski, Michael P., Zhao, Xumiao
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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