The evolution of amidine-based brain penetrant BACE1 inhibitors
Oehlrich, Daniel, Prokopcova, Hana, Gijsen, Harrie J.M.
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
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Journal Article
Copper-Mediated Radical Trifluoromethylation of Unsaturated Potassium Organotrifluoroborates
Presset, Marc, Oehlrich, Daniel, Rombouts, Frederik, Molander, Gary A
Published in Journal of organic chemistry (20.12.2013)
Published in Journal of organic chemistry (20.12.2013)
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Journal Article
Complementary Regioselectivity in Rh(III)-Catalyzed Insertions of Potassium Vinyltrifluoroborate via C–H Activation: Preparation and Use of 4‑Trifluoroboratotetrahydroisoquinolones
Presset, Marc, Oehlrich, Daniel, Rombouts, Frederik, Molander, Gary A
Published in Organic letters (05.04.2013)
Published in Organic letters (05.04.2013)
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Journal Article
Structural basis for the oligomerization-facilitated NLRP3 activation
Yu, Xiaodi, Matico, Rosalie E., Miller, Robyn, Chauhan, Dhruv, Van Schoubroeck, Bertrand, Grauwen, Karolien, Suarez, Javier, Pietrak, Beth, Haloi, Nandan, Yin, Yanting, Tresadern, Gary John, Perez-Benito, Laura, Lindahl, Erik, Bottelbergs, Astrid, Oehlrich, Daniel, Van Opdenbosch, Nina, Sharma, Sujata
Published in Nature communications (07.02.2024)
Published in Nature communications (07.02.2024)
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Journal Article
Post-translational insertion of boron in proteins to probe and modulate function
Mollner, Tim A., Isenegger, Patrick G., Josephson, Brian, Buchanan, Charles, Lercher, Lukas, Oehlrich, Daniel, Hansen, D. Flemming, Mohammed, Shabaz, Baldwin, Andrew J., Gouverneur, Véronique, Davis, Benjamin G.
Published in Nature chemical biology (01.12.2021)
Published in Nature chemical biology (01.12.2021)
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Journal Article
Synthesis and Minisci Reactions of Organotrifluoroborato Building Blocks
Presset, Marc, Fleury-Brégeot, Nicolas, Oehlrich, Daniel, Rombouts, Frederik, Molander, Gary A
Published in Journal of organic chemistry (03.05.2013)
Published in Journal of organic chemistry (03.05.2013)
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Journal Article
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.
Published in iScience (27.09.2019)
Published in iScience (27.09.2019)
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Journal Article
Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Iturrino, Laura, Linares, María Lourdes, Garcia, Aránzazu, Andrés, José Ignacio, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Megens, Anton, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Journal Article
Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)
Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, del Cerro, Alcira, Matesanz, Encarnación, Linares, María Lourdes, García, Aránzazu, Iturrino, Laura, Pérez-Benito, Laura, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Peeters, Luc, Ceusters, Marc, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Somers, Marijke, Trabanco, Andrés A
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Journal Article
Suzuki–Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs
Fleury-Brégeot, Nicolas, Presset, Marc, Beaumard, Floriane, Colombel, Virginie, Oehlrich, Daniel, Rombouts, Frederik, Molander, Gary A
Published in Journal of organic chemistry (16.11.2012)
Published in Journal of organic chemistry (16.11.2012)
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Journal Article
Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Cid, José María, Tresadern, Gary, Duvey, Guillaume, Lütjens, Robert, Finn, Terry, Rocher, Jean-Philippe, Poli, Sonia, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Linares, María Lourdes, Andrés, José Ignacio, Alcazar, Jesús, Alonso, José Manuel, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
Synthesis and Reactivity of Solid-Supported Organotrifluoroborates in Suzuki Cross-Coupling
Colombel, Virginie, Presset, Marc, Oehlrich, Daniel, Rombouts, Frederik, Molander, Gary A
Published in Organic letters (06.04.2012)
Published in Organic letters (06.04.2012)
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Journal Article
Scaffold Hopping to Imidazo[1,2‑a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor
de Lucas, Ana I, Vega, Juan A, García Molina, Aránzazu, Linares, María Lourdes, Tresadern, Gary, Lavreysen, Hilde, Oehlrich, Daniel, Trabanco, Andrés A, Cid, José M
Published in ACS omega (07.09.2021)
Published in ACS omega (07.09.2021)
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Journal Article
Synthesis of 5-hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-ones: selective antagonists of muscarinic (M-3) receptors
Bradshaw, Benjamin, Evans, Paul, Fletcher, Jane, Lee, Alan T. L., Mwashimba, Paul G., Oehlrich, Daniel, Thomas, Eric J., Davies, Robin H., Allen, Benjamin C. P., Broadley, Kenneth J., Hamrouni, Amar, Escargueil, Christine
Published in Organic & biomolecular chemistry (01.01.2008)
Published in Organic & biomolecular chemistry (01.01.2008)
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Journal Article
Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ‑Fluoroamines
Roagna, Giulia, Ascough, David M. H, Ibba, Francesco, Vicini, Anna Chiara, Fontana, Alberto, Christensen, Kirsten E, Peschiulli, Aldo, Oehlrich, Daniel, Misale, Antonio, Trabanco, Andrés A, Paton, Robert S, Pupo, Gabriele, Gouverneur, Véronique
Published in Journal of the American Chemical Society (19.08.2020)
Published in Journal of the American Chemical Society (19.08.2020)
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Journal Article
Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study
Keränen, Henrik, Pérez-Benito, Laura, Ciordia, Myriam, Delgado, Francisca, Steinbrecher, Thomas B, Oehlrich, Daniel, van Vlijmen, Herman W. T, Trabanco, Andrés A, Tresadern, Gary
Published in Journal of chemical theory and computation (14.03.2017)
Published in Journal of chemical theory and computation (14.03.2017)
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Journal Article
γ-Secretase Modulators as Potential Disease Modifying Anti-Alzheimer’s Drugs
Oehlrich, Daniel, Berthelot, Didier J.-C, Gijsen, Harrie J. M
Published in Journal of medicinal chemistry (10.02.2011)
Published in Journal of medicinal chemistry (10.02.2011)
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Journal Article
Mutated Toll-like receptor 9 increases Alzheimer’s disease risk by compromising innate immunity protection
Cacace, Rita, Zhou, Lujia, Hendrickx Van de Craen, Elisabeth, Buist, Arjan, Hoogmartens, Julie, Sieben, Anne, Cras, Patrick, Vandenberghe, Rik, De Deyn, Peter P., Oehlrich, Daniel, De Bondt, An, Engelborghs, Sebastiaan, Moechars, Diederik, Van Broeckhoven, Christine
Published in Molecular psychiatry (01.12.2023)
Published in Molecular psychiatry (01.12.2023)
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