Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J., McGovern, Karen, Kutok, Jeffery L., Wolchok, Jedd D., Merghoub, Taha
Published in Nature (London) (17.11.2016)
Published in Nature (London) (17.11.2016)
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Journal Article
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
Schaer, David A, Hirschhorn-Cymerman, Daniel, Wolchok, Jedd D
Published in Journal for Immunotherapy of Cancer (15.04.2014)
Published in Journal for Immunotherapy of Cancer (15.04.2014)
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Journal Article
Book Review
Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs
Nakahara, Takeshi, Uchi, Hiroshi, Lesokhin, Alexander M., Avogadri, Francesca, Rizzuto, Gabrielle A., Hirschhorn-Cymerman, Daniel, Panageas, Katherine S., Merghoub, Taha, Wolchok, Jedd D., Houghton, Alan N.
Published in Blood (03.06.2010)
Published in Blood (03.06.2010)
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Journal Article
Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity
Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F, Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N, Wolchok, Jedd D
Published in PloS one (10.09.2010)
Published in PloS one (10.09.2010)
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Journal Article
Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity
Ramirez-Montagut, Teresa, Chow, Andrew, Hirschhorn-Cymerman, Daniel, Terwey, Theis H, Kochman, Adam A, Lu, Sydney, Miles, Randy C, Sakaguchi, Shimon, Houghton, Alan N, van den Brink, Marcel R. M
Published in Journal of Immunology (01.06.2006)
Published in Journal of Immunology (01.06.2006)
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Journal Article
Overcoming resistance to checkpoint blockade therapy by targeting PI3K in myeloid cells
De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J, McGovern, Karen, Kutok, Jeffery L, Wolchok, Jedd D, Merghoub, Taha
Published in Nature (London) (17.11.2016)
Published in Nature (London) (17.11.2016)
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Journal Article
549 Characterizing double positive T cells in the tumor microenvironment: a tale of promiscuous cell fates
Schad, Sara, Chow, Andrew, Pan, Heng, Mangarin, Levi, Zappasodi, Roberta, Gigoux, Mathieu, Redmond, David, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Elemento, Olivier, Wolchok, Jedd, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Adjuvanticity of Plasmid DNA Encoding Cytokines Fused to Immunoglobulin Fc Domains
FERRONE, Cristina R, PERALES, Miguel-Angel, WOLCHOK, Jedd D, GOLDBERG, Stacie M, SOMBERG, C. Joy, HIRSCHHORN-CYMERMAN, Daniel, GREGOR, Polly D, TURK, Mary Jo, RAMIREZ-MONTAGUT, Teresa, GOLD, Jason S, HOUGHTON, Alan N
Published in Clinical cancer research (15.09.2006)
Published in Clinical cancer research (15.09.2006)
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Journal Article
ANTI-OX40 ANTIBODY AND METHOD FOR USING THE SAME
EKATERINA BREOUS-NYSTROM, GERD RITTER, DAVID SCHAER, TAHA MERGHOUB, DANIEL HIRSCHHORN-CYMERMAN, VOLKER SEIBERT, DAVID A SAVITSKY, HAO TANG, NICHOLAS S WILSON, MARC VAN DIJK, JEREMY WAIGHT
Year of Publication 24.10.2023
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Year of Publication 24.10.2023
Patent
ANTIBODIES AND METHODS OF USE THEREOF
GERD RITTER, DAVID SCHAER, TAHA MERGHOUB, EKATERINA V BREOUS-NYSTROM, DANIEL HIRSCHHORN-CYMERMAN, VOLKER SEIBERT, OLIVIER LEGER, NICHOLAS S WILSON, TSUJI TAKEMASA, JEREMY D WAIGHT, DENNIS J UNDERWOOD, MARC VAN DIJK
Year of Publication 28.07.2023
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Year of Publication 28.07.2023
Patent
ANTI-OX40 ANTIBODY AND METHOD FOR USING THE SAME
EKATERINA BREOUS-NYSTROM, GERD RITTER, DAVID SCHAER, TAHA MERGHOUB, DANIEL HIRSCHHORN-CYMERMAN, VOLKER SEIBERT, DAVID A SAVITSKY, HAO TANG, NICHOLAS S WILSON, MARC VAN DIJK, JEREMY WAIGHT
Year of Publication 15.07.2021
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Year of Publication 15.07.2021
Patent
Agonist Antibodies to TNFR Molecules That Costimulate T and NK Cells
MELERO, Ignacio, HIRSCHHORN-CYMERMAN, Daniel, MORALES-KASTRESANA, Aizea, SANMAMED, Miguel F, WOLCHOK, Jedd D
Published in Clinical cancer research (01.03.2013)
Published in Clinical cancer research (01.03.2013)
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Journal Article
Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
LESOKHIN, Alexander M, HOHL, Tobias M, MERGHOUB, Taha, WOLCHOK, Jedd D, KITANO, Shigehisa, CORTEZ, Czrina, HIRSCHHORN-CYMERMAN, Daniel, AVOGADRI, Francesca, RIZZUTO, Gabrielle A, LAZARUS, John J, PAME, Eric G, HOUGHTON, Alan N
Published in Cancer research (Chicago, Ill.) (15.02.2012)
Published in Cancer research (Chicago, Ill.) (15.02.2012)
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Journal Article
Phosphatidylserine targeting antibody enhances anti-tumor activity of adoptive cell therapies in a mouse melanoma model
Schad, Sara, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Merghoub, Taha, Wolchok, Jedd D
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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Journal Article
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype
Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Kitano, Shigehisa, Liu, Cailian, Zhao, Feng, Zhong, Hong, Lesokhin, Alexander M, Avogadri-Connors, Francesca, Yuan, Jianda, Li, Yanyun, Houghton, Alan N, Merghoub, Taha, Wolchok, Jedd D
Published in The Journal of experimental medicine (22.10.2012)
Published in The Journal of experimental medicine (22.10.2012)
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Journal Article
Immuno-PET imaging of activation markers on antigen-specific CD4 T cells in a mouse model of melanoma
Krebs, Simone, Carter, Lukas, Hirschhorn-Cymerman, Daniel, Wolchok, Jedd, Merghoub, Taha, Schoder, Heiko, Larson, Steven
Published in The Journal of nuclear medicine (1978) (01.05.2019)
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Published in The Journal of nuclear medicine (1978) (01.05.2019)
Journal Article
Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right
Ruby, Carl E, Yates, Melissa A, Hirschhorn-Cymerman, Daniel, Chlebeck, Peter, Wolchok, Jedd D, Houghton, Alan N, Offner, Halina, Weinberg, Andrew D
Published in The Journal of immunology (1950) (15.10.2009)
Published in The Journal of immunology (1950) (15.10.2009)
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Journal Article
Abstract 3568: Phosphatidylserine targeting antibody enhances antitumor activity of CAR T cells in mouse melanoma
Schad, Sara, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Shan, Joseph, King, Steven, Merghoub, Taha, Wolchok, Jedd
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis
Hirschhorn-Cymerman, Daniel, Rizzuto, Gabrielle A, Merghoub, Taha, Cohen, Adam D, Avogadri, Francesca, Lesokhin, Alexander M, Weinberg, Andrew D, Wolchok, Jedd D, Houghton, Alan N
Published in The Journal of experimental medicine (11.05.2009)
Published in The Journal of experimental medicine (11.05.2009)
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Journal Article
Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients
Kitano, Shigehisa, Tsuji, Takemasa, Liu, Caillian, Hirschhorn-Cymerman, Daniel, Kyi, Chrisann, Mu, Zhenyu, Allison, James P, Gnjatic, Sacha, Yuan, Jianda D, Wolchok, Jedd D
Published in Cancer immunology research (01.10.2013)
Published in Cancer immunology research (01.10.2013)
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