Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry
Bu, Hai-Zhi, Zhao, Ping, Dalvie, Deepak K., Pool, William F.
Published in Rapid communications in mass spectrometry (30.10.2007)
Published in Rapid communications in mass spectrometry (30.10.2007)
Get full text
Journal Article
Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and 1H Nuclear Magnetic Resonance
PRAKASH, Chandra, WEICHAO CHEN, ROSSULEK, Michelle, JOHNSON, Kim, CHENGHONG ZHANG, O'CONNELL, Thomas, POTCHOIBA, Michael, DALVIE, Deepak
Published in Drug metabolism and disposition (01.10.2008)
Published in Drug metabolism and disposition (01.10.2008)
Get full text
Journal Article
Investigation into MAO B-Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of ( S )-Enantiomer of Indaneamine (RP101075) by MAO B
Bai, April, Shanmugasundaram, Veerabahu, Selkirk, Julie V, Surapaneni, Sekhar, Dalvie, Deepak
Published in Drug metabolism and disposition (01.08.2021)
Published in Drug metabolism and disposition (01.08.2021)
Get full text
Journal Article
Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)
Ma, Yong, Fu, Yue, Khojasteh, S Cyrus, Dalvie, Deepak, Zhang, Donglu
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
Get full text
Journal Article
Future of Biotransformation Science in the Pharmaceutical Industry
Kramlinger, Valerie M, Dalvie, Deepak, Heck, Carley J S, Kalgutkar, Amit S, O'Neill, James, Su, Dian, Teitelbaum, Aaron M, Totah, Rheem A
Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
Get full text
Journal Article
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
Selkirk, Julie V, Dines, Kevin C, Yan, Yingzhuo Grace, Ching, Nathan, Dalvie, Deepak, Biswas, Shameek, Bortolato, Andrea, Schkeryantz, Jeffrey M, Lopez, Carlos, Ruiz, Iliana, Hargreaves, Richard
Published in The Journal of pharmacology and experimental therapeutics (01.12.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2021)
Get full text
Journal Article
Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8): Miniperspective
Ma, Yong, Fu, Yue, Khojasteh, S. Cyrus, Dalvie, Deepak, Zhang, Donglu
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
Get full text
Journal Article
Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
Get full text
Journal Article
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections
Hawryluk, Natalie, Robinson, Dale, Shen, Yixing, Kyne, Graham, Bedore, Matthew, Menon, Sanjay, Canan, Stacie, von Geldern, Thomas, Townson, Simon, Gokool, Suzanne, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Dalvie, Deepak, Specht, Sabine, Hübner, Marc Peter, Scandale, Ivan
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
Get full text
Journal Article
Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
Get full text
Journal Article
Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites
Dalvie, Deepak, Obach, R. Scott, Kang, Ping, Prakash, Chandra, Loi, Cho-Ming, Hurst, Susan, Nedderman, Angus, Goulet, Lance, Smith, Evan, Bu, Hai-Zhi, Smith, Dennis A
Published in Chemical research in toxicology (01.02.2009)
Published in Chemical research in toxicology (01.02.2009)
Get full text
Journal Article
Contribution of membrane trafficking perturbation to retinal toxicity
Khoh-Reiter, Su, Sokolowski, Sharon A, Jessen, Bart, Evans, Mark, Dalvie, Deepak, Lu, Shuyan
Published in Toxicological sciences (01.06.2015)
Published in Toxicological sciences (01.06.2015)
Get full text
Journal Article
Which metabolites circulate?
Loi, Cho-Ming, Smith, Dennis A, Dalvie, Deepak
Published in Drug metabolism and disposition (01.05.2013)
Published in Drug metabolism and disposition (01.05.2013)
Get full text
Journal Article
A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes
O’Hara, Fionn, Burns, Aaron C, Collins, Michael R, Dalvie, Deepak, Ornelas, Martha A, Vaz, Alfin D. N, Fujiwara, Yuta, Baran, Phil S
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
Get full text
Journal Article
Biotransformation and bioactivation reactions - 2016 literature highlights
Khojasteh, S. Cyrus, Rietjens, Ivonne M. C. M., Dalvie, Deepak, Miller, Grover
Published in Drug metabolism reviews (03.07.2017)
Published in Drug metabolism reviews (03.07.2017)
Get full text
Journal Article