Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates
Kalgutkar, Amit S, Dalvie, Deepak
Published in Annual review of pharmacology and toxicology (06.01.2015)
Published in Annual review of pharmacology and toxicology (06.01.2015)
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Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Surapaneni, Sekhar, Yerramilli, Usha, Bai, April, Dalvie, Deepak, Brooks, Jennifer, Wang, Xiaomin, Selkirk, Julie V, Yan, Yingzhuo Grace, Zhang, Peijin, Hargreaves, Richard, Kumar, Gondi, Palmisano, Maria, Tran, Jonathan Q
Published in Drug metabolism and disposition (01.05.2021)
Published in Drug metabolism and disposition (01.05.2021)
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Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
Schwartz, Phillip A., Kuzmic, Petr, Solowiej, James, Bergqvist, Simon, Bolanos, Ben, Almaden, Chau, Nagata, Asako, Ryan, Kevin, Feng, Junli, Dalvie, Deepak, Kath, John C., Xu, Meirong, Wani, Revati, Murray, Brion William
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate
Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Cordonnier, Marie, Dalvie, Deepak, Deroose, Frederik, Feng, Jun Li, Gomes, Bruno, Greasley, Samantha, Kaiser, Stephen E, Kraus, Manfred, Négrerie, Michel, Maegley, Karen, Miller, Nichol, Murray, Brion W, Schneider, Manfred, Soloweij, James, Stewart, Albert E, Tumang, Joseph, Torti, Vince R, Van Den Eynde, Benoit, Wythes, Martin
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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A comprehensive listing of bioactivation pathways of organic functional groups
Kalgutkar, Amit S, Gardner, Iain, Obach, R Scott, Shaffer, Christopher L, Callegari, Ernesto, Henne, Kirk R, Mutlib, Abdul E, Dalvie, Deepak K, Lee, Jae S, Nakai, Yasuhiro, O'Donnell, John P, Boer, Jason, Harriman, Shawn P
Published in Current drug metabolism (01.06.2005)
Published in Current drug metabolism (01.06.2005)
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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy
Gomes, Bruno, Driessens, Gregory, Bartlett, Derek, Cai, Danying, Cauwenberghs, Sandra, Crosignani, Stefano, Dalvie, Deepak, Denies, Sofie, Dillon, Christopher P, Fantin, Valeria R, Guo, Jie, Letellier, Marie-Claire, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Pirson, Romain, Rabolli, Virginie, Ray, Chad, Streiner, Nicole, Torti, Vince R, Tsaparikos, Konstantinos, Van den Eynde, Benoit J, Wythes, Martin, Yao, Li-Chin, Zheng, Xianxian, Tumang, Joseph, Kraus, Manfred
Published in Molecular cancer therapeutics (01.12.2018)
Published in Molecular cancer therapeutics (01.12.2018)
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Journal Article
Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings
Dalvie, Deepak K, Kalgutkar, Amit S, Khojasteh-Bakht, S. Cyrus, Obach, R. Scott, O'Donnell, John P
Published in Chemical research in toxicology (01.03.2002)
Published in Chemical research in toxicology (01.03.2002)
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Journal Article
The Generation, Detection, and Effects of Reactive Drug Metabolites
Stachulski, Andrew V., Baillie, Thomas A., Kevin Park, B., Scott Obach, R., Dalvie, Deepak K., Williams, Dominic P., Srivastava, Abhishek, Regan, Sophie L., Antoine, Daniel J., Goldring, Christopher E. P., Chia, Alvin J. L., Kitteringham, Neil R., Randle, Laura E., Callan, Hayley, Castrejon, J. Luis, Farrell, John, Naisbitt, Dean J., Lennard, Martin S.
Published in Medicinal research reviews (01.09.2013)
Published in Medicinal research reviews (01.09.2013)
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Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide
Dalvie, Deepak, Sun, Hao, Xiang, Cathie, Hu, Qiyue, Jiang, Ying, Kang, Ping
Published in Drug metabolism and disposition (01.08.2012)
Published in Drug metabolism and disposition (01.08.2012)
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Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans
Smith, Bill J, Pithavala, Yazdi, Bu, Hai-Zhi, Kang, Ping, Hee, Brian, Deese, Alan J, Pool, William F, Klamerus, Karen J, Wu, Ellen Y, Dalvie, Deepak K
Published in Drug metabolism and disposition (01.05.2014)
Published in Drug metabolism and disposition (01.05.2014)
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Identification of Novel Substrates for Human Cytochrome P450 2J2
LEE, Caroline A, NEUL, David, CLOUSER-ROCHE, Andrea, DALVIE, Deepak, WESTER, Michael R, YING JIANG, JONES, J. P, FREIWALD, Sascha, ZIENTEK, Michael, TOTAH, Rheem A
Published in Drug metabolism and disposition (01.02.2010)
Published in Drug metabolism and disposition (01.02.2010)
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Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery
Pryde, David C, Dalvie, Deepak, Hu, Qiyue, Jones, Peter, Obach, R. Scott, Tran, Thien-Duc
Published in Journal of medicinal chemistry (23.12.2010)
Published in Journal of medicinal chemistry (23.12.2010)
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Cross-Species Comparison of the Metabolism and Excretion of Zoniporide: Contribution of Aldehyde Oxidase to Interspecies Differences
DALVIE, Deepak, CHENGHONG ZHANG, WEICHAO CHEN, SMOLAREK, Teresa, OBACH, R. Scott, LOI, Cho-Ming
Published in Drug metabolism and disposition (01.04.2010)
Published in Drug metabolism and disposition (01.04.2010)
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Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects
Johnson, Theodore R., Tan, Weiwei, Goulet, Lance, Smith, Evan B., Yamazaki, Shinji, Walker, Gregory S., O'Gorman, Melissa T., Bedarida, Gabriella, Zou, Helen Y., Christensen, James G., Nguyen, Leslie N., Shen, Zhongzhou, Dalvie, Deepak, Bello, Akintunde, Smith, Bill J.
Published in Xenobiotica (01.01.2015)
Published in Xenobiotica (01.01.2015)
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Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
Eng, Heather, Sharma, Raman, Wolford, Angela, Di, Li, Ruggeri, Roger B, Buckbinder, Leonard, Conn, Edward L, Dalvie, Deepak K, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.08.2016)
Published in Drug metabolism and disposition (01.08.2016)
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Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice
Silber, B. Michael, Rao, Satish, Fife, Kimberly L., Gallardo-Godoy, Alejandra, Renslo, Adam R., Dalvie, Deepak K., Giles, Kurt, Freyman, Yevgeniy, Elepano, Manuel, Gever, Joel R., Li, Zhe, Jacobson, Matthew P., Huang, Yong, Benet, Leslie Z., Prusiner, Stanley B.
Published in Pharmaceutical research (01.04.2013)
Published in Pharmaceutical research (01.04.2013)
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