mexEF-oprN Multidrug Efflux Operon of Pseudomonas aeruginosa: Regulation by the MexT Activator in Response to Nitrosative Stress and Chloramphenicol
FETAR, Hossam, GILMOUR, Christie, KLINOSKI, Rachael, DAIGLE, Denis M, DEAN, Charles R, POOLE, Keith
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
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Fmt Bypass in Pseudomonas aeruginosa Causes Induction of MexXY Efflux Pump Expression
CAUGHLAN, Ruth E, SRIRAM, Shubha, DAIGLE, Denis M, WOODS, Angela L, BUCO, Jennifer, PETERSON, Ron L, DZINK-FOX, Joann, WALKER, Susan, DEAN, Charles R
Published in Antimicrobial Agents and Chemotherapy (01.12.2009)
Published in Antimicrobial Agents and Chemotherapy (01.12.2009)
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Protein Modulator of Multidrug Efflux Gene Expression in Pseudomonas aeruginosa
DAIGLE, Denis M, LILY CAO, FRAUD, Sebastien, WILKE, Mark S, PACEY, Angela, KLINOSKI, Rachael, STRYNADKA, Natalie C, DEAN, Charles R, POOLE, Keith
Published in Journal of Bacteriology (01.08.2007)
Published in Journal of Bacteriology (01.08.2007)
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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W, Hamrick, Jodie C, Daigle, Denis M, Cusick, Susan M, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J, Pevear, Daniel C, Xerri, Luigi, Burns, Christopher J
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa
Hamrick, Jodie C, Docquier, Jean-Denis, Uehara, Tsuyoshi, Myers, Cullen L, Six, David A, Chatwin, Cassandra L, John, Kaitlyn J, Vernacchio, Salvador F, Cusick, Susan M, Trout, Robert E L, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Liu, Bin, Jackson, Randy W, Moeck, Greg, Xerri, Luigi, Burns, Christopher J, Pevear, Daniel C, Daigle, Denis M
Published in Antimicrobial agents and chemotherapy (21.02.2020)
Published in Antimicrobial agents and chemotherapy (21.02.2020)
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In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program
Karlowsky, James A, Hackel, Meredith A, Wise, Mark G, Six, David A, Uehara, Tsuyoshi, Daigle, Denis M, Cusick, Susan M, Pevear, Daniel C, Moeck, Greg, Sahm, Daniel F
Published in Antimicrobial agents and chemotherapy (24.01.2023)
Published in Antimicrobial agents and chemotherapy (24.01.2023)
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Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415
DEAN, Charles R, NARAYAN, Shubha, RYDER, Neil S, DAIGLE, Denis M, DZINK-FOX, Joann L, XIAOLING PUYANG, BRACKEN, Kathryn R, DEAN, Karl E, WEIDMANN, Beat, ZHENGYU YUAN, JAIN, Rakesh
Published in Antimicrobial Agents and Chemotherapy (01.08.2005)
Published in Antimicrobial Agents and Chemotherapy (01.08.2005)
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Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of Enterobacterales Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases
Chatwin, Cassandra L, Hamrick, Jodie C, Trout, Robert E L, Myers, Cullen L, Cusick, Susan M, Weiss, William J, Pulse, Mark E, Xerri, Luigi, Burns, Christopher J, Moeck, Gregory, Daigle, Denis M, John, Kaitlyn, Uehara, Tsuyoshi, Pevear, Daniel C
Published in Antimicrobial agents and chemotherapy (16.07.2021)
Published in Antimicrobial agents and chemotherapy (16.07.2021)
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Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Copy Number
CHARLES, R, NARAYAN, Shubha, VOSHOL, Hans, VAN OOSTRUM, Jan, WALL, Daniel, KOEHN, James, DZINK-FOX, Joann, RYDER, Neil S, RICHARDS, Joel, DAIGLE, Denis M, ESTEROW, Stacy, LEEDS, Jennifer A, KAMP, Heather, PUYANG, Xiaoling, WIEDMANN, Brigitte, MUELLER, Dieter
Published in Antimicrobial Agents and Chemotherapy (01.03.2007)
Published in Antimicrobial Agents and Chemotherapy (01.03.2007)
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A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region
Summerfield, Rachael L, Daigle, Denis M, Mayer, Stanislas, Mallik, Debasis, Hughes, Donald W, Jackson, Sean G, Sulek, Margaret, Organ, Michael G, Brown, Eric D, Junop, Murray S
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate
Zolli-Juran, Michela, Cechetto, Jonathan D., Hartlen, Rebecca, Daigle, Denis M., Brown, Eric D.
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
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YjeQ, an Essential, Conserved, Uncharacterized Protein from Escherichia coli, Is an Unusual GTPase with Circularly Permuted G-Motifs and Marked Burst Kinetics
Daigle, Denis M, Rossi, Laura, Berghuis, Albert M, Aravind, L, Koonin, Eugene V, Brown, Eric D
Published in Biochemistry (Easton) (17.09.2002)
Published in Biochemistry (Easton) (17.09.2002)
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Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors
Daigle, Denis M., McKay, Geoffrey A., Wright, Gerard D.
Published in The Journal of biological chemistry (03.10.1997)
Published in The Journal of biological chemistry (03.10.1997)
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Cefepime–taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa : GEARS global surveillance programme 2018–22
Karlowsky, James A, Wise, Mark G, Hackel, Meredith A, Six, David A, Uehara, Tsuyoshi, Daigle, Denis M, Pevear, Daniel C, Moeck, Greg, Sahm, Daniel F
Published in Journal of antimicrobial chemotherapy (17.09.2024)
Published in Journal of antimicrobial chemotherapy (17.09.2024)
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A 2.13 angstrom structure of E-coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region
Summerfield, Rachael L., Daigle, Denis M., Mayer, Stanislas, Mallik, Debasis, Hughes, Donald W., Jackson, Sean G., Sulek, Margaret, Organ, Michael G., Brown, Eric D., Junop, Murray S.
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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