Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models
Nono, Justin Komguep, Fu, Kai, Mpotje, Thabo, Varrone, Georgianna, Aziz, Nada Abdel, Mosala, Paballo, Hlaka, Lerato, Kamdem, Severin Donald, Xu, Daigen, Spangenberg, Thomas, Brombacher, Frank
Published in Scientific reports (30.06.2020)
Published in Scientific reports (30.06.2020)
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RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents
Xu, Daigen, Kim, Yong, Postelnek, Jennifer, Vu, Minh Diem, Hu, Dong-Qing, Liao, Cheng, Bradshaw, Mike, Hsu, Jonathan, Zhang, Jun, Pashine, Achal, Srinivasan, Dinesh, Woods, John, Levin, Anita, O'Mahony, Alison, Owens, Timothy D, Lou, Yan, Hill, Ronald J, Narula, Satwant, DeMartino, Julie, Fine, Jay S
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
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Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis
Nakanishi, Masako, Montrose, David C, Clark, Patsy, Nambiar, Prashant R, Belinsky, Glenn S, Claffey, Kevin P, Xu, Daigen, Rosenberg, Daniel W
Published in Cancer research (Chicago, Ill.) (01.05.2008)
Published in Cancer research (Chicago, Ill.) (01.05.2008)
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MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
Xu, Daigen, Rowland, Steven E, Clark, Patsy, Giroux, André, Côté, Bernard, Guiral, Sébastien, Salem, Myriam, Ducharme, Yves, Friesen, Richard W, Méthot, Nathalie, Mancini, Joseph, Audoly, Laurent, Riendeau, Denis
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Journal Article
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
Côté, Bernard, Boulet, Louise, Brideau, Christine, Claveau, David, Ethier, Diane, Frenette, Richard, Gagnon, Marc, Giroux, André, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Martins, Evelyn, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis
Clark, Patsy, Rowland, Steven E, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Poirier, Hugo, Burch, Jason, Han, Yongxin, Audoly, Laurent, Therien, Alex G, Xu, Daigen
Published in The Journal of pharmacology and experimental therapeutics (01.05.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2008)
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Journal Article
Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis
Pulichino, Anne-Marie, Rowland, Steve, Wu, Tom, Clark, Patsy, Xu, Daigen, Mathieu, Marie-Claude, Riendeau, Denis, Audoly, Laurent P
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Journal Article
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors
Giroux, André, Boulet, Louise, Brideau, Christine, Chau, Anh, Claveau, David, Côté, Bernard, Ethier, Diane, Frenette, Richard, Gagnon, Marc, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Martins, Evelyn, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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Journal Article
Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury
Han, Byung Hee, Xu, Daigen, Choi, Junjeong, Han, Yongxin, Xanthoudakis, Steven, Roy, Sophie, Tam, John, Vaillancourt, John, Colucci, John, Siman, Robert, Giroux, Andre, Robertson, George S., Zamboni, Robert, Nicholson, Donald W., Holtzman, David M.
Published in The Journal of biological chemistry (16.08.2002)
Published in The Journal of biological chemistry (16.08.2002)
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Journal Article
Trisubstituted ureas as potent and selective mPGES-1 inhibitors
Chiasson, Jean-François, Boulet, Louise, Brideau, Christine, Chau, Anh, Claveau, David, Côté, Bernard, Ethier, Diane, Giroux, André, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Roy, Patrick, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo
Zhang, Jun, Preda, Dorin V, Vasquez, Kristine O, Morin, Jeff, Delaney, Jeannine, Bao, Bagna, Percival, M David, Xu, Daigen, McKay, Dan, Klimas, Michael, Bednar, Bohumil, Sur, Cyrille, Gao, David Z, Madden, Karen, Yared, Wael, Rajopadhye, Milind, Peterson, Jeffrey D
Published in American journal of physiology. Renal physiology (15.08.2012)
Published in American journal of physiology. Renal physiology (15.08.2012)
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Journal Article
A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism
Boyd, Michael J., Berthelette, Carl, Chiasson, Jean-François, Clark, Patsy, Colucci, John, Denis, Danielle, Han, Yongxin, Lévesque, Jean-Francois, Mathieu, Marie-Claude, Stocco, Rino, Therien, Alex, Rowland, Steve, Wrona, Mark, Xu, Daigen
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Dual, Constrictor-to-Dilator, Response of the Mouse Ductus Arteriosus to the Microsomal Prostaglandin E Synthase-1 Inhibitor, 2-(6-Chloro-1H-phenanthro[9,10d]imidazole- 2-yl)isophthalonitrile
Baragatti, Barbara, Scebba, Francesca, Sodini, Daria, Pagni, Eleonora, Ciofini, Enrica, Xu, Daigen, Coceani, Flavio
Published in Neonatology (Basel, Switzerland) (01.01.2011)
Published in Neonatology (Basel, Switzerland) (01.01.2011)
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Journal Article
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP₄ receptor
Burch, Jason D, Farand, Julie, Colucci, John, Sturino, Claudio, Ducharme, Yves, Friesen, Richard W, Lévesque, Jean-François, Gagné, Sébastien, Wrona, Mark, Therien, Alex G, Mathieu, Marie-Claude, Denis, Danielle, Vigneault, Erika, Xu, Daigen, Clark, Patsy, Rowland, Steve, Han, Yongxin
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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Journal Article
Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus
Xu, Daigen, Bureau, Yves, McIntyre, Dan C, Nicholson, Donald W, Liston, Peter, Zhu, Yanxia, Fong, Wei Gin, Crocker, Stephen J, Korneluk, Robert G, Robertson, George S
Published in The Journal of neuroscience (15.06.1999)
Published in The Journal of neuroscience (15.06.1999)
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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor
BURCH, Jason D, BELLEY, Michel, VIGNEAULT, Erika, LEVESQUE, Jean-Francois, GAGNE, Sébastien, WRONA, Mark, DAIGEN XU, CLARK, Patsy, ROWLAND, Steve, YONGXIN HAN, FORTIN, Réjean, DESCHENES, Denis, GIRARD, Mario, COLUCCI, John, FARAND, Julie, THERIEN, Alex G, MATHIEU, Marie-Claude, DENIS, Danielle
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species
Rowland, Steven E., Clark, Patsy, Gordon, Robert, Mullen, Anne K., Guay, Jocelyne, Dufresne, Lynn, Brideau, Christine, Cote, Bernard, Ducharme, Yves, Mancini, Joseph, Chan, Chi-chung, Audoly, Laurent, Xu, Daigen
Published in European journal of pharmacology (10.04.2007)
Published in European journal of pharmacology (10.04.2007)
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Journal Article
Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain
Colucci, John, Boyd, Michael, Berthelette, Carl, Chiasson, Jean-Francois, Wang, Zhaoyin, Ducharme, Yves, Friesen, Rick, Wrona, Mark, Levesque, Jean-Francois, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Therien, Alex G., Clarke, Patsy, Rowland, Steve, Xu, Daigen, Han, Yongxin
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Journal Article
NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease
Crocker, Stephen J., Wigle, Nichola, Liston, Peter, Thompson, Charlie S., Lee, Chris J., Xu, Daigen, Roy, Sophie, Nicholson, Donald W., Park, David S., MacKenzie, Alex, Korneluk, Robert G., Robertson, George S.
Published in The European journal of neuroscience (01.07.2001)
Published in The European journal of neuroscience (01.07.2001)
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Journal Article
Suppression of Glomerulonephritis in Lupus‐Prone NZB × NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase
Mina‐Osorio, Paola, LaStant, Jacob, Keirstead, Natalie, Whittard, Toni, Ayala, Julia, Stefanova, Stella, Garrido, Rosario, Dimaano, Nena, Hilton, Holly, Giron, Mario, Lau, Kai‐Yeung, Hang, Julie, Postelnek, Jennifer, Kim, Yong, Min, Soo, Patel, Alka, Woods, John, Ramanujam, Meera, DeMartino, Julie, Narula, Satwant, Xu, Daigen
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.09.2013)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.09.2013)
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