Btk inhibition treats TLR7/IFN driven murine lupus
Bender, Andrew T, Pereira, Albertina, Fu, Kai, Samy, Eileen, Wu, Yin, Liu-Bujalski, Lesley, Caldwell, Richard, Chen, Yi-Ying, Tian, Hui, Morandi, Federica, Head, Jared, Koehler, Ursula, Genest, Melinda, Okitsu, Shinji L, Xu, Daigen, Grenningloh, Roland
Published in Clinical immunology (Orlando, Fla.) (01.03.2016)
Published in Clinical immunology (Orlando, Fla.) (01.03.2016)
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Automated analysis of global ischemia-induced CA1 neuronal death using terminal UTP nick end labeling (TUNEL)
Davoli, Maria Antonietta, Ren, Yubo, Zhu, Yanxia, Fourtounis, Jimmy, Jones, Cindy, Robertson, George S, Ng, Gordon Y.K, Xu, Daigen
Published in Journal of neuroscience methods (30.03.2002)
Published in Journal of neuroscience methods (30.03.2002)
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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy
Liao, Cheng, Hsu, Jonathan, Kim, Yong, Hu, Dong-Qing, Xu, Daigen, Zhang, Jun, Pashine, Achal, Menke, John, Whittard, Toni, Romero, Natasha, Truitt, Theresa, Slade, Michelle, Lukacs, Christine, Hermann, Johannes, Zhou, Mingyan, Lucas, Matthew, Narula, Satwant, DeMartino, Julie, Tan, Seng-Lai
Published in Arthritis research & therapy (04.10.2013)
Published in Arthritis research & therapy (04.10.2013)
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Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody‐driven K/BxN serum–transfer arthritis
Chen, Mei, Boilard, Eric, Nigrovic, Peter A., Clark, Patsy, Xu, Daigen, FitzGerald, Garret A., Audoly, Laurent P., Lee, David M.
Published in Arthritis and rheumatism (01.05.2008)
Published in Arthritis and rheumatism (01.05.2008)
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Discovery of Affinity‐Based Probes for Btk Occupancy Assays
Qiu, Hui, Caldwell, Richard, Liu‐Bujalski, Lesley, Goutopoulos, Andreas, Jones, Reinaldo, Potnick, Justin, Sherer, Brian, Bender, Andrew, Grenningloh, Roland, Xu, Daigen, Gardberg, Anna, Mochalkin, Igor, Johnson, Theresa, Viacava Follis, Ariele, Head, Jared, Morandi, Federica
Published in ChemMedChem (22.01.2019)
Published in ChemMedChem (22.01.2019)
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Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors
Padilla, Fernando, Bhagirath, Niala, Chen, Shaoqing, Chiao, Eric, Goldstein, David M, Hermann, Johannes C, Hsu, Jonathan, Kennedy-Smith, Joshua J, Kuglstatter, Andreas, Liao, Cheng, Liu, Wenjian, Lowrie, Lee E, Luk, Kin Chun, Lynch, Stephen M, Menke, John, Niu, Linghao, Owens, Timothy D, O-Yang, Counde, Railkar, Aruna, Schoenfeld, Ryan C, Slade, Michelle, Steiner, Sandra, Tan, Yun-Chou, Villaseñor, Armando G, Wang, Ce, Wanner, Jutta, Xie, Wenwei, Xu, Daigen, Zhang, Xiaohu, Zhou, Mingyan, Lucas, Matthew C
Published in Journal of medicinal chemistry (28.02.2013)
Published in Journal of medicinal chemistry (28.02.2013)
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Journal Article
Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors
Lucas, Matthew C, Bhagirath, Niala, Chiao, Eric, Goldstein, David M, Hermann, Johannes C, Hsu, Pei-Yuan, Kirchner, Stephan, Kennedy-Smith, Joshua J, Kuglstatter, Andreas, Lukacs, Christine, Menke, John, Niu, Linghao, Padilla, Fernando, Peng, Ying, Polonchuk, Liudmila, Railkar, Aruna, Slade, Michelle, Soth, Michael, Xu, Daigen, Yadava, Preeti, Yee, Calvin, Zhou, Mingyan, Liao, Cheng
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation
Gervais, François G., Xu, Daigen, Robertson, George S., Vaillancourt, John P., Zhu, Yanxia, Huang, JingQi, LeBlanc, Andréa, Smith, David, Rigby, Michael, Shearman, Mark S., Clarke, Earl E., Zheng, Hui, Van Der Ploeg, Leonardus H.T., Ruffolo, Salvatore C., Thornberry, Nancy A., Xanthoudakis, Steve, Zamboni, Robert J., Roy, Sophie, Nicholson, Donald W.
Published in Cell (30.04.1999)
Published in Cell (30.04.1999)
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The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E-2 Subtype 4 Receptor Antagonist
Blouin, Marc, Han, Yongxin, Burch, Jason, Farand, Julie, Mellon, Christophe, Gaudreault, Mireille, Wrona, Mark, Levesque, Jean-Francois, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Vigneault, Erika, Therien, Alex, Clark, Patsy, Rowland, Steve, Xu, Daigen, O'Neill, Gary, Ducharme, Yves, Friesen, Rick
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E2 Subtype 4 Receptor Antagonist
Blouin, Marc, Han, Yongxin, Burch, Jason, Farand, Julie, Mellon, Christophe, Gaudreault, Mireille, Wrona, Mark, Lévesque, Jean-François, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Vigneault, Erika, Therien, Alex, Clark, Patsy, Rowland, Steve, Xu, Daigen, O’Neill, Gary, Ducharme, Yves, Friesen, Rick
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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DNA binding of methyl iodide in male and female F344 rats
Gansewendt, B, Xu, D, Foest, U, Hallier, E, Bolt, H M, Peter, H
Published in Carcinogenesis (New York) (01.03.1991)
Published in Carcinogenesis (New York) (01.03.1991)
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A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo
JUN ZHANG, PREDA, Dorin V, BEDNAR, Bohumil, SUR, Cyrille, GAO, David Z, MADDEN, Karen, YARED, Wael, RAJOPADHYE, Milind, PETERSON, Jeffrey D, VASQUEZ, Kristine O, MORIN, Jeff, DELANEY, Jeannine, BAO, Bagna, PERCIVAL, M. David, DAIGEN XU, MCKAY, Dan, KLIMAS, Michael
Published in American journal of physiology. Renal physiology (2012)
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Published in American journal of physiology. Renal physiology (2012)
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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP sub(4) receptor
Burch, Jason D, Farand, Julie, Colucci, John, Sturino, Claudio, Ducharme, Yves, Friesen, Richard W, Levesque, Jean-Francois, Gagne, Sebastien, Wrona, Mark, Therien, Alex G, Mathieu, Marie-Claude, Denis, Danielle, Vigneault, Erika, Xu, Daigen, Clark, Patsy, Rowland, Steve, Han, Yongxin
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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Journal Article
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP 4 receptor
Burch, Jason D., Farand, Julie, Colucci, John, Sturino, Claudio, Ducharme, Yves, Friesen, Richard W., Lévesque, Jean-François, Gagné, Sébastien, Wrona, Mark, Therien, Alex G., Mathieu, Marie-Claude, Denis, Danielle, Vigneault, Erika, Xu, Daigen, Clark, Patsy, Rowland, Steve, Han, Yongxin
Published in Bioorganic & medicinal chemistry letters (2011)
Published in Bioorganic & medicinal chemistry letters (2011)
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Development of a homogeneous immunoassay for the detection of angiotensin I in plasma using AlphaLISA acceptor beads technology
Cauchon, Elizabeth, Liu, Susana, Percival, M. David, Rowland, Steve E., Xu, Daigen, Binkert, Christoph, Strickner, Panja, Falgueyret, Jean-Pierre
Published in Analytical biochemistry (01.05.2009)
Published in Analytical biochemistry (01.05.2009)
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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP sub(4) receptor
Burch, Jason D, Belley, Michel, tin, Rejean, Deschenes, Denis, Girard, Mario, Colucci, John, Farand, Julie, Therien, Alex G, Mathieu, Marie-Claude, Denis, Danielle, Vigneault, Erika, Levesque, Jean-Francois, Gagne, Sebastien, Wrona, Mark, Xu, Daigen, Clark, Patsy, Rowland, Steve, Han, Yongxin
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP 4 receptor
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Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
Bender, Andrew, Varrone, Georgianna, Celik, Ilhan, Urban, Miriam, Staub, Eike, Wu, Yin, Raab-Westphal, Sabine, Xu, Daigen, Samy, Eileen
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
Patent
Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
Bender, Andrew, Celik, Ilhan, Urban, Miriam, Staub, Eike, Higginbotham, Georgianna, Wu, Yin, Xu, Daigen, Samy, Eileen, Raab, Sabine
Year of Publication 14.12.2023
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Year of Publication 14.12.2023
Patent
Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
Bender, Andrew, Celik, Ilhan, Urban, Miriam, Staub, Eike, Higginbotham, Georgianna, Wu, Yin, Xu, Daigen, Samy, Eileen, Raab, Sabine
Year of Publication 24.11.2023
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Year of Publication 24.11.2023
Patent