Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Zenke, Frank T, Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.05.2020)
Published in Molecular cancer therapeutics (01.05.2020)
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Journal Article
Functional analysis of Hsp70 inhibitors
Schlecht, Rainer, Scholz, Sebastian R, Dahmen, Heike, Wegener, Ansgar, Sirrenberg, Christian, Musil, Djordje, Bomke, Joerg, Eggenweiler, Hans-Michael, Mayer, Matthias P, Bukau, Bernd
Published in PloS one (12.11.2013)
Published in PloS one (12.11.2013)
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A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Mapping combinatorial drug effects to DNA damage response kinase inhibitors
Zhang, Hanrui, Kreis, Julian, Schelhorn, Sven-Eric, Dahmen, Heike, Grombacher, Thomas, Zühlsdorf, Michael, Zenke, Frank T, Guan, Yuanfang
Published in Nature communications (14.12.2023)
Published in Nature communications (14.12.2023)
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Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy
Zenke, Frank T., Zimmermann, Astrid, Dahmen, Heike, Elenbaas, Brian, Pollard, John, Reaper, Philip, Bagrodia, S, Spilker, M E., Amendt, C, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Correction: Functional Analysis of Hsp70 Inhibitors
Schlecht, Rainer, Scholz, Sebastian R., Dahmen, Heike, Wegener, Ansgar, Sirrenberg, Christian, Musil, Djordje, Bomke, Joerg, Eggenweiler, Hans-Michael, Mayer, Matthias P., Bukau, Bernd
Published in PloS one (19.12.2013)
Published in PloS one (19.12.2013)
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The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction
Schmitz, Jochen, Dahmen, Heike, Grimm, Carsten, Gendo, Cornelia, Muller-Newen, Gerhard, Heinrich, Peter C, Schaper, Fred
Published in The Journal of immunology (1950) (15.01.2000)
Published in The Journal of immunology (1950) (15.01.2000)
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Importance of the Membrane-Proximal Extracellular Domains for Activation of the Signal Transducer Glycoprotein 130
Kurth, Ingo, Horsten, Ursula, Pflanz, Stefan, Timmermann, Andreas, Kuster, Andrea, Dahmen, Heike, Tacken, Ingrid, Heinrich, Peter C, Muller-Newen, Gerhard
Published in The Journal of immunology (1950) (01.01.2000)
Published in The Journal of immunology (1950) (01.01.2000)
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Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Thomas, Anish, Takahashi, Nobuyuki, Rajapakse, Vinodh N, Zhang, Xiaohu, Sun, Yilun, Ceribelli, Michele, Wilson, Kelli M, Zhang, Yang, Beck, Erin, Sciuto, Linda, Nichols, Samantha, Elenbaas, Brian, Puc, Janusz, Dahmen, Heike, Zimmermann, Astrid, Varonin, Jillian, Schultz, Christopher W, Kim, Sehyun, Shimellis, Hirity, Desai, Parth, Klumpp-Thomas, Carleen, Chen, Lu, Travers, Jameson, McKnight, Crystal, Michael, Sam, Itkin, Zina, Lee, Sunmin, Yuno, Akira, Lee, Min-Jung, Redon, Christophe E, Kindrick, Jessica D, Peer, Cody J, Wei, Jun S, Aladjem, Mirit I, Figg, William Douglas, Steinberg, Seth M, Trepel, Jane B, Zenke, Frank T, Pommier, Yves, Khan, Javed, Thomas, Craig J
Published in Cancer cell (12.04.2021)
Published in Cancer cell (12.04.2021)
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Journal Article
A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130
Pflanz, Stefan, Tacken, Ingrid, Grötzinger, Joachim, Jacques, Yannick, Dahmen, Heike, Heinrich, Peter C., Müller-Newen, Gerhard
Published in FEBS letters (30.04.1999)
Published in FEBS letters (30.04.1999)
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Journal Article
Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Molecular cancer therapeutics (05.07.2023)
Published in Molecular cancer therapeutics (05.07.2023)
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Journal Article
Abstract 329: Highly potent and selective ATM kinase inhibitor M3541: A clinical candidate drug with strong antitumor activity in combination with radiotherapy
Fuchss, Thomas, Mederski, Werner W., Zenke, Frank T., Dahmen, Heike, Zimmermann, Astrid, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 3500: Highly potent and selective ATM kinase inhibitor M4076: A clinical candidate drug with strong anti-tumor activity in combination therapies
Fuchss, Thomas, Graedler, Ulrich, Schiemann, Kai, Kuhn, Daniel, Kubas, Holger, Dahmen, Heike, Zimmermann, Astrid, Zenke, Frank, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 338: A new investigational ATM Inhibitor, M3541, synergistically potentiates fractionated radiotherapy and chemotherapy in cancer cells and animal models
Zimmermann, Astrid, Zenke, Frank, Dahmen, Heike, Sirrenberg, Christian, Grombacher, Thomas, Vassilev, Lyubomir T., Fuchss, Thomas, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2588: M1774, a novel potent and selective ATR inhibitor, shows antitumor effects as monotherapy and in combination
Zimmermann, Astrid, Dahmen, Heike, Grombacher, Thomas, Pehl, Ulrich, Blaukat, Andree, Zenke, Frank T.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 6212: Inhibition of ATM-dependent checkpoint control and DNA double-strand break repair enhances the efficacy of ATR inhibitors
Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 1658: M3814, a novel investigational DNA-PK inhibitor: enhancing the effect of fractionated radiotherapy leading to complete regression of tumors in mice
Zenke, Frank T., Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Vassilev, Lubo, Pehl, Ulrich, Fuchss, Thomas, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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대상체에서의 암을 치료하기 위한 화합물 및 이의 용도
DAHMEN HEIKE, ZIMMERMANN ASTRID, GROMBACHER THOMAS, ORTIZ RUIZ MARIA JESUS
Year of Publication 23.11.2020
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Year of Publication 23.11.2020
Patent
암 치료를 위한 PD-1 안타고니스트, ATR 억제제 및 백금화제의 조합
FALK MARTIN, DAHMEN HEIKE, TADJALLI MEHR KEYVAN, ALIMZHANOV MARAT, SOULARD PATRICIA, ZENKE FRANK, SCHROEDER ANDREAS, ZIMMERMANN ASTRID
Year of Publication 07.06.2021
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Year of Publication 07.06.2021
Patent
Definition of receptor binding sites on human interleukin‐11 by molecular modeling‐guided mutagenesis
Tacken, Ingrid, Dahmen, Heike, Boisteau, Olivier, Minvielle, Stéphane, Jacques, Yannick, Grötzinger, Joachim, Küster, Andrea, Horsten, Ursula, Blanc, Chrystel, A. Montero‐Julian, Felix, Heinrich, Peter C., Müller‐Newen, Gerhard
Published in European journal of biochemistry (01.10.1999)
Published in European journal of biochemistry (01.10.1999)
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