Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib
Huang, Qinhua, Johnson, Ted W, Bailey, Simon, Brooun, Alexei, Bunker, Kevin D, Burke, Benjamin J, Collins, Michael R, Cook, Andrew S, Cui, J. Jean, Dack, Kevin N, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Johnson, Patrick S, Kania, Robert S, Lam, Hieu, Lam, Justine L, Le, Phuong T, Li, Qiuhua, Lingardo, Laura, Liu, Wei, Lu, Melissa West, McTigue, Michele, Palmer, Cynthia L, Richardson, Paul F, Sach, Neal W, Shen, Hong, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Tsaparikos, Konstantinos, Wang, Hui, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Woon, Esther C. Y, Demetriades, Marina, Bagg, Eleanor A. L, Aik, WeiShen, Krylova, Svetlana M, Ma, Jerome H. Y, Chan, MunChiang, Walport, Louise J, Wegman, David W, Dack, Kevin N, McDonough, Michael A, Krylov, Sergey N, Schofield, Christopher J
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability
Johnson, Patrick S., Ryckmans, Thomas, Bryans, Justin, Beal, Dave M., Dack, Kevin N., Feeder, Neil, Harrison, Anthony, Lewis, Mark, Mason, Helen J., Mills, James, Newman, Julie, Pasquinet, Christelle, Rawson, Dave J., Roberts, Lee R., Russell, Rachel, Spark, Deborah, Stobie, Alan, Underwood, Toby J., Ward, Robin, Wheeler, Simon
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Journal Article
Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases
Andrews, Mark D., Dack, Kevin N., de Groot, Marcel J., Lambert, Maja, Sennbro, Carl J., Larsen, Mogens, Stahlhut, Martin
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Journal Article
The design and synthesis of a novel series of indole derived selective ETA antagonists
RAWSON, David J, DACK, Kevin N, DICKINSON, Roger P, JAMES, Kim
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
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Journal Article
Fragment-Based Discovery of 6‑Arylindazole JAK Inhibitors
Ritzén, Andreas, Sørensen, Morten D, Dack, Kevin N, Greve, Daniel R, Jerre, Anders, Carnerup, Martin A, Rytved, Klaus A, Bagger-Bahnsen, Jesper
Published in ACS medicinal chemistry letters (09.06.2016)
Published in ACS medicinal chemistry letters (09.06.2016)
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Acidic triazoles as soluble guanylate cyclase stimulators
Roberts, Lee R., Bradley, Paul A., Bunnage, Mark E., England, Katherine S., Fairman, David, Fobian, Yvette M., Fox, David N.A., Gymer, Geoff E., Heasley, Steven E., Molette, Jerome, Smith, Graham L., Schmidt, Michelle A., Tones, Michael A., Dack, Kevin N.
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Journal Article
Optimisation of a pyrazole series of progesterone antagonists; Part 1
Dack, Kevin N., Skerratt, Sarah, Johnson, Patrick S., Bradley, Paul A., Marsh, Ian R.
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Journal Article
Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors
Glossop, Melanie S., Bazin, Richard J., Dack, Kevin N., Fox, David N.A., MacDonald, Graeme A., Mills, Mark, Owen, Dafydd R., Phillips, Chris, Reeves, Keith A., Ringer, Tracy J., Strang, Ross S., Watson, Christine A.L.
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
A novel series of highly selective inhibitors of MMP-3
Whitlock, Gavin A., Dack, Kevin N., Dickinson, Roger P., Lewis, Mark L.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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Journal Article
Absorption, Distribution, Metabolism, and Excretion Considerations in Selection of Orally Active Indole-Containing Endothelin Antagonist
WALKER, Donald K, DACK, Kevin N, DICKINSON, Roger P, FENNER, Katherine S, JAMES, Kim, RAWSON, David J, SMITH, Dennis A
Published in Drug metabolism and disposition (01.11.2001)
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Published in Drug metabolism and disposition (01.11.2001)
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Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists
Dickinson, Roger P, Dack, Kevin N, Long, Clive J, Steele, John
Published in Journal of medicinal chemistry (10.10.1997)
Published in Journal of medicinal chemistry (10.10.1997)
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Journal Article
A mild and selective C-3 reductive alkylation of indoles
Appleton, Julie E., Dack, Kevin N., Green, Andrew D., Steele, John
Published in Tetrahedron letters (26.02.1993)
Published in Tetrahedron letters (26.02.1993)
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Journal Article
The design and synthesis of a novel series of indole derived selective ET A antagonists
Rawson, David J, Dack, Kevin N, Dickinson, Roger P, James, Kim
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
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Journal Article
Thromboxane Modulating Agents. 3. 1 H -Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists
Dickinson, Roger P., Dack, Kevin N., Long, Clive J., Steele, John
Published in Journal of medicinal chemistry (01.10.1997)
Published in Journal of medicinal chemistry (01.10.1997)
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Journal Article
The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist
Rawson, David J., Dack, Kevin N., Dickinson, Roger P., James, Kim, Long, Clive, Walker, Don
Published in Medicinal chemistry research (01.01.2004)
Published in Medicinal chemistry research (01.01.2004)
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Journal Article
Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists
Dickinson, Roger P., Dack, Kevin N., Steele, John
Published in Bioorganic & medicinal chemistry letters (21.12.1995)
Published in Bioorganic & medicinal chemistry letters (21.12.1995)
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Journal Article
Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists
Dack, Kevin N., Dickinson, Roger P., Long, Clive J., Steele, John
Published in Bioorganic & medicinal chemistry letters (18.08.1998)
Published in Bioorganic & medicinal chemistry letters (18.08.1998)
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