Systematic Approach to Conformational Sampling for Assigning Absolute Configuration Using Vibrational Circular Dichroism
Sherer, Edward C., Lee, Claire H., Shpungin, Joseph, Cuff, James F., Da, Chenxiao, Ball, Richard, Bach, Richard, Crespo, Alejandro, Gong, Xiaoyi, Welch, Christopher J.
Published in Journal of medicinal chemistry (23.01.2014)
Published in Journal of medicinal chemistry (23.01.2014)
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Journal Article
Chemical genetic-based phenotypic screen reveals novel regulators of gluconeogenesis in human primary hepatocytes
Zou, Haixia, Liu, Qian, Meng, Li, Zhou, Jingye, Da, Chenxiao, Wu, Xikun, Jiang, Lichun, Shou, Jianyong, Hua, Haiqing
Published in Npj genomic medicine (15.08.2018)
Published in Npj genomic medicine (15.08.2018)
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Journal Article
How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site
Da, Chenxiao, Mooberry, Susan L, Gupton, John T, Kellogg, Glen E
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Journal Article
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology
Da, Chenxiao, Zhang, Dehui, Stashko, Michael, Vasileiadi, Eleana, Parker, Rebecca E, Minson, Katherine A, Huey, Madeline G, Huelse, Justus M, Hunter, Debra, Gilbert, Thomas S. K, Norris-Drouin, Jacqueline, Miley, Michael, Herring, Laura E, Graves, Lee M, DeRyckere, Deborah, Earp, H. Shelton, Graham, Douglas K, Frye, Stephen V, Wang, Xiaodong, Kireev, Dmitri
Published in Journal of the American Chemical Society (02.10.2019)
Published in Journal of the American Chemical Society (02.10.2019)
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Journal Article
Data-driven construction of anti-tumor agents with controlled polypharmacology
Da, Chenxiao, Zhang, Dehui, Stashko, Michael, Vasileiadi, Eleana, Parker, Rebecca, Minson, Katherine A., Huey, Madeline G., Huelse, Justus M., Hunter, Debra, Gilbert, Thomas S. K., Norris-Drouin, Jacqueline, Miley, Michael, Herring, Laura E., Graves, Lee M., DeRyckere, Deborah, Earp, H. Shelton, Graham, Douglas, Frye, Stephen V., Wang, Xiaodong, Kireev, Dmitri
Published in Journal of the American Chemical Society (20.09.2019)
Published in Journal of the American Chemical Society (20.09.2019)
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Journal Article
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design
Rohena, Cristina C, Telang, Nakul S, Da, Chenxiao, Risinger, April L, Sikorski, James A, Kellogg, Glen E, Gupton, John T, Mooberry, Susan L
Published in Molecular pharmacology (01.02.2016)
Published in Molecular pharmacology (01.02.2016)
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Journal Article
Pharmacophore modeling of human adenosine receptor A(₂A) antagonists
Xu, Zhejun, Cheng, Feixiong, Da, Chenxiao, Liu, Guixia, Tang, Yun
Published in Journal of molecular modeling (01.12.2010)
Published in Journal of molecular modeling (01.12.2010)
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Journal Article
Pharmacophore modeling of human adenosine receptor A2A antagonists
Xu, Zhejun, Cheng, Feixiong, Da, Chenxiao, Liu, Guixia, Tang, Yun
Published in Journal of molecular modeling (2010)
Published in Journal of molecular modeling (2010)
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Journal Article
Pyrrole-Based Antitubulin Agents: Two Distinct Binding Modalities Are Predicted for C-2 Analogues in the Colchicine Site
Da, Chenxiao, Telang, Nakul, Barelli, Peter, Jia, Xin, Gupton, John T, Mooberry, Susan L, Kellogg, Glen E
Published in ACS medicinal chemistry letters (12.01.2012)
Published in ACS medicinal chemistry letters (12.01.2012)
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Journal Article
Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site
Da, Chenxiao, Telang, Nakul, Hall, Kayleigh, Kluball, Emily, Barelli, Peter, Finzel, Kara, Jia, Xin, Gupton, John T, Mooberry, Susan L, Kellogg, Glen E
Published in MedChemComm (2013)
Published in MedChemComm (2013)
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Journal Article
Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine siteElectronic supplementary information (ESI) available: Experimental details for the synthesis and characterization of reported compounds, procedures for the assays and additional information on the computational methods utilized. See DOI: 10.1039/c2md20320k
Da, Chenxiao, Telang, Nakul, Hall, Kayleigh, Kluball, Emily, Barelli, Peter, Finzel, Kara, Jia, Xin, Gupton, John T, Mooberry, Susan L, Kellogg, Glen E
Year of Publication 30.01.2013
Year of Publication 30.01.2013
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Journal Article
Pharmacophore modeling of human adenosine receptor A₂A antagonists
Xu, Zhejun, Cheng, Feixiong, Da, Chenxiao, Liu, Guixia, Tang, Yun
Published in Molecular modeling annual (2010)
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Published in Molecular modeling annual (2010)
Journal Article
Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof
Sikorski, James A, Rohena, Cristina, Kellogg, Glen E, Telang, Nakul, Da, Chenxiao, Tripathi, Ashutosh, Gupton, John T, Mooberry, Susan L
Year of Publication 17.04.2018
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Year of Publication 17.04.2018
Patent
POLYSUBSTITUTED PYRROLES HAVING MICROTUBULE-DISRUPTING, CYTOTOXIC AND ANTITUMOR ACTIVITIES AND METHDS OF USE THEREOF
TELANG, NANKUL, SIKORSKI, JAMES, A, TRIPATHI, ASHUTOSH, ROHENA, CRISTINA, KELLOGG, GLEN, E, GUPTON, JOHN, T, MOOBERRY, SUSAN, L, DA, CHENXIAO
Year of Publication 19.03.2015
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Year of Publication 19.03.2015
Patent
Amino-substituted pyridone derivative, preparation method therefor and pharmaceutical use thereof
CHEN YONGGANG, LIU LIFENG, ONG ZHONG'AN, GUAN HUIPING, WANG HAILONG, JIANG TAO, ZHOU FUSHENG, TANG WANGQI, DA CHENXIAO, LI SHAOBO, WANG SHENGYUAN, XU FENG
Year of Publication 25.09.2020
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Year of Publication 25.09.2020
Patent
AMINO-SUBSTITUTED PYRIDONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
DA, Chenxiao, TONG, Zhong'an, WANG, Shengyuan, LIU, Lifeng, CHEN, Yonggang, ZHOU, Fusheng, XU, Feng, JIANG, Tao, TANG, Wangqi, LI, Shaobo, GUAN, Huiping, WANG, Hailong
Year of Publication 04.06.2020
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Year of Publication 04.06.2020
Patent