Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
Primiano, Michael J, Lefker, Bruce A, Bowman, Michael R, Bree, Andrea G, Hubeau, Cedric, Bonin, Paul D, Mangan, Matthew, Dower, Ken, Monks, Brian G, Cushing, Leah, Wang, Stephen, Guzova, Julia, Jiao, Aiping, Lin, Lih-Ling, Latz, Eicke, Hepworth, David, Hall, J Perry
Published in The Journal of immunology (1950) (15.09.2016)
Published in The Journal of immunology (1950) (15.09.2016)
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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals
Aleo, Michael D, Shah, Falgun, He, Kan, Bonin, Paul D, Rodrigues, A. David
Published in Chemical research in toxicology (15.05.2017)
Published in Chemical research in toxicology (15.05.2017)
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PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis
Zheng, Wei, Warner, Roscoe, Ruggeri, Roger, Su, Chunyan, Cortes, Christian, Skoura, Athanasia, Ward, Jessica, Ahn, Kay, Kalgutkar, Amit, Sun, Dexue, Maurer, Tristan S, Bonin, Paul D, Okerberg, Carlin, Bobrowski, Walter, Kawabe, Thomas, Zhang, Yanwei, Coskran, Timothy, Bell, Sammy, Kapoor, Bhupesh, Johnson, Kent, Buckbinder, Leonard
Published in The Journal of pharmacology and experimental therapeutics (01.05.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2015)
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Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
Yu, Xiaodi, Plotnikova, Olga, Bonin, Paul D, Subashi, Timothy A, McLellan, Thomas J, Dumlao, Darren, Che, Ye, Dong, Yin Yao, Carpenter, Elisabeth P, West, Graham M, Qiu, Xiayang, Culp, Jeffrey S, Han, Seungil
Published in eLife (03.10.2019)
Published in eLife (03.10.2019)
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Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response
McClure, Kim F, Darout, Etzer, Guimarães, Cristiano R. W, DeNinno, Michael P, Mascitti, Vincent, Munchhof, Michael J, Robinson, Ralph P, Kohrt, Jeffrey, Harris, Anthony R, Moore, Dianna E, Li, Bryan, Samp, Lacey, Lefker, Bruce A, Futatsugi, Kentaro, Kung, Daniel, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Salter, Eben, Hornby, Sam, Kalgutkar, Amit S, Chen, Yue
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Oxidative Metabolism of a Quinoxaline Derivative by Xanthine Oxidase in Rodent Plasma
Sharma, Raman, Eng, Heather, Walker, Gregory S, Barreiro, Gabriela, Stepan, Antonia F, McClure, Kim F, Wolford, Angela, Bonin, Paul D, Cornelius, Peter, Kalgutkar, Amit S
Published in Chemical research in toxicology (19.12.2011)
Published in Chemical research in toxicology (19.12.2011)
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Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump
Aleo, Michael D., Luo, Yi, Swiss, Rachel, Bonin, Paul D., Potter, David M., Will, Yvonne
Published in Hepatology (Baltimore, Md.) (01.09.2014)
Published in Hepatology (Baltimore, Md.) (01.09.2014)
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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis
Aleo, Michael D., Aubrecht, Jiri, D. Bonin, Paul, Burt, Deborah A., Colangelo, Jennifer, Luo, Lina, Schomaker, Shelli, Swiss, Rachel, Kirby, Simon, C. Rigdon, Greg, Dua, Pinky
Published in Pharmacology research & perspectives (01.02.2019)
Published in Pharmacology research & perspectives (01.02.2019)
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Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists
Humphries, Paul S., Benbow, John W., Bonin, Paul D., Boyer, David, Doran, Shawn D., Frisbie, Richard K., Piotrowski, David W., Balan, Gayatri, Bechle, Bruce M., Conn, Edward L., Dirico, Kenneth J., Oliver, Robert M., Soeller, Walter C., Southers, James A., Yang, Xiaojing
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor
Mascitti, Vincent, Stevens, Benjamin D., Choi, Chulho, McClure, Kim F., Guimarães, Cristiano R.W., Farley, Kathleen A., Munchhof, Michael J., Robinson, Ralph P., Futatsugi, Kentaro, Lavergne, Sophie Y., Lefker, Bruce A., Cornelius, Peter, Bonin, Paul D., Kalgutkar, Amit S., Sharma, Raman, Chen, Yue
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Discovery of 2‑(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)‑yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases
Ruggeri, Roger B, Buckbinder, Leonard, Bagley, Scott W, Carpino, Philip A, Conn, Edward L, Dowling, Matthew S, Fernando, Dilinie P, Jiao, Wenhua, Kung, Daniel W, Orr, Suvi T. M, Qi, Yingmei, Rocke, Benjamin N, Smith, Aaron, Warmus, Joseph S, Zhang, Yan, Bowles, Daniel, Widlicka, Daniel W, Eng, Heather, Ryder, Tim, Sharma, Raman, Wolford, Angela, Okerberg, Carlin, Walters, Karen, Maurer, Tristan S, Zhang, Yanwei, Bonin, Paul D, Spath, Samantha N, Xing, Gang, Hepworth, David, Ahn, Kay, Kalgutkar, Amit S
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals
Aleo, Michael D, Shah, Falgun, He, Kan, Bonin, Paul D, Rodrigues, A. David
Published in Chemical research in toxicology (19.06.2017)
Published in Chemical research in toxicology (19.06.2017)
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Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities
Chekler, Eugene L. Piatnitski, Pellegrino, Jessica A., Lanz, Thomas A., Denny, R. Aldrin, Flick, Andrew C., Coe, Jotham, Langille, Jonathan, Basak, Arindrajit, Liu, Shenping, Stock, Ingrid A., Sahasrabudhe, Parag, Bonin, Paul D., Lee, Kevin, Pletcher, Mathew T., Jones, Lyn H.
Published in Chemistry & biology (17.12.2015)
Published in Chemistry & biology (17.12.2015)
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Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119
Darout, Etzer, Robinson, Ralph P, McClure, Kim F, Corbett, Matthew, Li, Bryan, Shavnya, Andrei, Andrews, Melissa P, Jones, Christopher S, Li, Qifang, Minich, Martha L, Mascitti, Vincent, Guimarães, Cristiano R. W, Munchhof, Michael J, Bahnck, Kevin B, Cai, Cuiman, Price, David A, Liras, Spiros, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Bagdasarian, Victoria, Sobota, Colleen P, Hornby, Sam, Masterson, Victoria M, Joseph, Reena M, Kalgutkar, Amit S, Chen, Yue
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
Futatsugi, Kentaro, Mascitti, Vincent, Guimarães, Cristiano R.W., Morishita, Nao, Cai, Cuiman, DeNinno, Michael P., Gao, Hua, Hamilton, Michael D., Hank, Richard, Harris, Anthony R., Kung, Daniel W., Lavergne, Sophie Y., Lefker, Bruce A., Lopaze, Michael G., McClure, Kim F., Munchhof, Michael J., Preville, Cathy, Robinson, Ralph P., Wright, Stephen W., Bonin, Paul D., Cornelius, Peter, Chen, Yue, Kalgutkar, Amit S.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Correction: Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins
Wu, Jiang, Shin, Julia, Williams, Cara M. M, Geoghegan, Kieran F, Wright, Stephen W, Limburg, David C, Sahasrabudhe, Parag, Bonin, Paul D, Lefker, Bruce A, Ramsey, Simeon J
Published in MedChemComm (05.01.2015)
Published in MedChemComm (05.01.2015)
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Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis
Mott, John E., Shaw, Bailin A., Smith, James F., Bonin, Paul D., Romero, Donna L., Marotti, Keith R., Miller, Alita A.
Published in Journal of antimicrobial chemotherapy (01.10.2008)
Published in Journal of antimicrobial chemotherapy (01.10.2008)
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Expression, Purification, and Characterization of Peptidyl-tRNA Hydrolase from Staphylococcus aureus
Bonin, Paul D., Choi, Gil H., Trepod, Catherine M., Mott, John E., Lyle, Stephen B., Cialdella, Joyce I., Sarver, Ronald W., Marshall, Vincent P., Erickson, Laurence A.
Published in Protein expression and purification (01.02.2002)
Published in Protein expression and purification (01.02.2002)
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