Transient interdomain interactions in free USP14 shape its conformational ensemble
Salomonsson, Johannes, Wallner, Björn, Sjöstrand, Linda, D'Arcy, Pádraig, Sunnerhagen, Maria, Ahlner, Alexandra
Published in Protein science (01.05.2024)
Published in Protein science (01.05.2024)
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Journal Article
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Zhang, Xiaonan, Fryknäs, Mårten, Hernlund, Emma, Fayad, Walid, De Milito, Angelo, Olofsson, Maria Hägg, Gogvadze, Vladimir, Dang, Long, Påhlman, Sven, Schughart, Leoni A. Kunz, Rickardson, Linda, D′Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf, Linder, Stig
Published in Nature communications (2014)
Published in Nature communications (2014)
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Journal Article
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
Mofers, Arjan, Perego, Paola, Selvaraju, Karthik, Gatti, Laura, Gullbo, Joachim, Linder, Stig, D'Arcy, Padraig
Published in PloS one (22.10.2019)
Published in PloS one (22.10.2019)
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Journal Article
Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells
Colombo, Diego, Gatti, Laura, Sjöstrand, Linda, Carenini, Nives, Costantino, Matteo, Corna, Elisabetta, Arrighetti, Noemi, Zuccolo, Marco, De Cesare, Michelandrea, Linder, Stig, D'Arcy, Pádraig, Perego, Paola
Published in Biochemical pharmacology (01.03.2022)
Published in Biochemical pharmacology (01.03.2022)
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Journal Article
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
Selvaraju, Karthik, Mofers, Arjan, Pellegrini, Paola, Salomonsson, Johannes, Ahlner, Alexandra, Morad, Vivian, Hillert, Ellin-Kristina, Espinosa, Belen, Arnér, Elias S. J., Jensen, Lasse, Malmström, Jonas, Turkina, Maria V., D’Arcy, Padraig, Walters, Michael A., Sunnerhagen, Maria, Linder, Stig
Published in Scientific reports (08.07.2019)
Published in Scientific reports (08.07.2019)
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Journal Article
Iron chelators target both proliferating and quiescent cancer cells
Fryknäs, Mårten, Zhang, Xiaonan, Bremberg, Ulf, Senkowski, Wojciech, Olofsson, Maria Hägg, Brandt, Peter, Persson, Ingmar, D’Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Schughart, Leoni Kunz, Linder, Stig, Larsson, Rolf
Published in Scientific reports (07.12.2016)
Published in Scientific reports (07.12.2016)
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Journal Article
Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation
Hillert, Ellin-Kristina, Brnjic, Slavica, Zhang, Xiaonan, Mazurkiewicz, Magdalena, Saei, Amir Ata, Mofers, Arjan, Selvaraju, Karthik, Zubarev, Roman, Linder, Stig, D'Arcy, Padraig
Published in Cancer letters (28.04.2019)
Published in Cancer letters (28.04.2019)
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Journal Article
Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation
Zhu, Geyunjian H., Azharuddin, Mohammad, Pramanik, Bapan, Roberg, Karin, Biswas, Sujoy Kumar, D’arcy, Padraig, Lu, Meng, Kaur, Apanpreet, Chen, Alexander, Dhara, Ashis Kumar, Chivu, Alexandru, Zhuang, Yunhui, Baker, Andrew, Liu, Xiewen, Fairen-Jimenez, David, Mazumder, Bismoy, Chen, Rongjun, Kaminski, Clemens F., Kaminski Schierle, Gabriele S., Hinkula, Jorma, Slater, Nigel K. H., Patra, Hirak K.
Published in ACS applied materials & interfaces (12.04.2023)
Published in ACS applied materials & interfaces (12.04.2023)
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Journal Article
Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress
Brnjic, Slavica, Mazurkiewicz, Magdalena, Fryknäs, Mårten, Sun, Chao, Zhang, Xiaonan, Larsson, Rolf, D'Arcy, Pádraig, Linder, Stig
Published in Antioxidants & redox signaling (10.12.2014)
Published in Antioxidants & redox signaling (10.12.2014)
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Journal Article
Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system
Sarhan, Dhifaf, D'Arcy, Padraig, Lundqvist, Andreas
Published in International journal of molecular sciences (14.10.2014)
Published in International journal of molecular sciences (14.10.2014)
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Journal Article
Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics
Girgis, Adel S, D'Arcy, Padraig, Aboshouk, Dalia R, Bekheit, Mohamed S
Published in RSC advances (2022)
Published in RSC advances (2022)
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Journal Article
A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini, Paola, Serviss, Jason T, Lundbäck, Thomas, Bancaro, Nicolo, Mazurkiewicz, Magdalena, Kolosenko, Iryna, Yu, Di, Haraldsson, Martin, D'Arcy, Padraig, Linder, Stig, De Milito, Angelo
Published in Cancer cell international (25.09.2018)
Published in Cancer cell international (25.09.2018)
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Journal Article
The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis
Corno, Cristina, D'Arcy, Padraig, Bagnoli, Marina, Paolini, Biagio, Costantino, Matteo, Carenini, Nives, Corna, Elisabetta, Alberti, Paola, Mezzanzanica, Delia, Colombo, Diego, Linder, Stig, Arrighetti, Noemi, Perego, Paola
Published in Frontiers in cell and developmental biology (2022)
Published in Frontiers in cell and developmental biology (2022)
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Journal Article
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells
Sarhan, Dhifaf, Wennerberg, Erik, D’Arcy, Padraig, Gurajada, Deepthy, Linder, Stig, Lundqvist, Andreas
Published in Cancer Immunology, Immunotherapy (01.08.2013)
Published in Cancer Immunology, Immunotherapy (01.08.2013)
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Journal Article
Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
Selvaraju, Karthik, Mofers, Arjan, Pellegrini, Paola, Salomonsson, Johannes, Ahlner, Alexandra, Morad, Vivian, Hillert, Ellin-Kristina, Espinosa, Belen, Arnér, Elias S. J., Jensen, Lasse, Malmström, Jonas, Turkina, Maria V., D’Arcy, Padraig, Walters, Michael A., Sunnerhagen, Maria, Linder, Stig
Published in Scientific reports (20.11.2019)
Published in Scientific reports (20.11.2019)
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Journal Article
MYC is downregulated by a mitochondrial checkpoint mechanism
Zhang, Xiaonan, Mofers, Arjan, Hydbring, Per, Olofsson, Maria Hägg, Guo, Jing, Linder, Stig, D'Arcy, Padraig
Published in Oncotarget (2017)
Published in Oncotarget (2017)
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Journal Article
The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death
Wang, Xin, Stafford, William, Mazurkiewicz, Magdalena, Fryknäs, Mårten, Brjnic, Slavica, Zhang, Xiaonan, Gullbo, Joachim, Larsson, Rolf, Arnér, Elias S J, D'Arcy, Padraig, Linder, Stig
Published in Molecular pharmacology (2014)
Published in Molecular pharmacology (2014)
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Journal Article
Activated monocytes augment TRAIL‐mediated cytotoxicity by human NK cells through release of IFN‐γ
Sarhan, Dhifaf, D'Arcy, Padraig, Wennerberg, Erik, Lidén, Majken, Hu, Jin, Winqvist, Ola, Rolny, Charlotte, Lundqvist, Andreas
Published in European journal of immunology (01.01.2013)
Published in European journal of immunology (01.01.2013)
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Journal Article