VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells
Moore, Jonathan D, Staniszewska, Anna, Shaw, Terence, D'Alessandro, Jalanie, Davis, Ben, Surgenor, Alan, Baker, Lisa, Matassova, Natalia, Murray, James, Macias, Alba, Brough, Paul, Wood, Mike, Mahon, Patrick C
Published in Oncotarget (30.12.2014)
Published in Oncotarget (30.12.2014)
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Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase
Brough, Paul A, Baker, Lisa, Bedford, Simon, Brown, Kirsten, Chavda, Seema, Chell, Victoria, D’Alessandro, Jalanie, Davies, Nicholas G. M, Davis, Ben, Le Strat, Loic, Macias, Alba T, Maddox, Daniel, Mahon, Patrick C, Massey, Andrew J, Matassova, Natalia, McKenna, Sean, Meissner, Johannes W. G, Moore, Jonathan D, Murray, James B, Northfield, Christopher J, Parry, Charles, Parsons, Rachel, Roughley, Stephen D, Shaw, Terry, Simmonite, Heather, Stokes, Stephen, Surgenor, Allan, Stefaniak, Emma, Robertson, Alan, Wang, Yikang, Webb, Paul, Whitehead, Neil, Wood, Mike
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
Hart, Terance, Macias, Alba T., Benwell, Karen, Brooks, Teresa, D’Alessandro, Jalanie, Dokurno, Pawel, Francis, Geraint, Gibbons, Ben, Haymes, Timothy, Kennett, Guy, Lightowler, Sean, Mansell, Howard, Matassova, Natalia, Misra, Anil, Padfield, Anthony, Parsons, Rachel, Pratt, Robert, Robertson, Alan, Walls, Steven, Wong, Melanie, Roughley, Stephen
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity
Roughley, Stephen D., Browne, Helen, Macias, Alba T., Benwell, Karen, Brooks, Teresa, D’Alessandro, Jalanie, Daniels, Zoe, Dugdale, Sarah, Francis, Geraint, Gibbons, Ben, Hart, Terance, Haymes, Timothy, Kennett, Guy, Lightowler, Sean, Matassova, Natalia, Mansell, Howard, Merrett, Angela, Misra, Anil, Padfield, Anthony, Parsons, Rachel, Pratt, Robert, Robertson, Alan, Simmonite, Heather, Tan, Kiri, Walls, Steven B., Wong, Melanie
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Abstract B155: VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and demonstrates context-dependent cytotoxicity to cancer cells
Moore, Jonathan, Staniszewska, Anna, Shaw, Terence, D'Alessandro, Jalanie, Davis, Ben, Surgenor, Alan, Baker, Lisa, Massanova, Natalia, Murray, James, Macias, Alba, Brough, Paul, Wood, Mike, Mahon, Patrick C.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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