Transient CHO expression platform for robust antibody production and its enhanced N‐glycan sialylation on therapeutic glycoproteins
Zhong, Xiaotian, Ma, Weijun, Meade, Caryl L., Tam, Amy S., Llewellyn, Eliza, Cornell, Richard, Cote, Kaffa, Scarcelli, John J., Marshall, Jeffrey K., Tzvetkova, Boriana, Figueroa, Bruno, DiNino, Dana, Sievers, Annette, Lee, Christopher, Guo, Jane, Mahan, Evan, Francis, Christopher, Lam, Khetemenee, D'Antona, Aaron M., Zollner, Richard, Zhu, Hongli L., Kriz, Ron, Somers, Will, Lin, Laura
Published in Biotechnology progress (01.01.2019)
Published in Biotechnology progress (01.01.2019)
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Journal Article
Membrane Assembly of the Cannabinoid Receptor 1: Impact of a Long N-Terminal Tail
Andersson, H, D'Antona, AM, Kendall, DA, Von Heijne, G, Chin, CN
Published in Molecular pharmacology (01.09.2003)
Published in Molecular pharmacology (01.09.2003)
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Journal Article
Tyrosine Sulfation at Antibody Light Chain CDR-1 Increases Binding Affinity and Neutralization Potency to Interleukine-4
D'Antona, Aaron M, Lee, Julie M, Zhang, Melvin, Friedman, Clarence, He, Tao, Mosyak, Lidia, Bennett, Eric, Lin, Laura, Silverman, Maddison, Cometa, Funi, Meade, Caryl, Hageman, Tyler, Sousa, Eric, Cohen, Justin, Marquette, Kimberly, Ferguson, Darren, Zhong, Xiaotian
Published in International journal of molecular sciences (01.02.2024)
Published in International journal of molecular sciences (01.02.2024)
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Journal Article
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
Apgar, James R, Tam, Amy S P, Sorm, Rhady, Moesta, Sybille, King, Amy C, Yang, Han, Kelleher, Kerry, Murphy, Denise, D'Antona, Aaron M, Yan, Guoying, Zhong, Xiaotian, Rodriguez, Linette, Ma, Weijun, Ferguson, Darren E, Carven, Gregory J, Bennett, Eric M, Lin, Laura
Published in PloS one (07.05.2020)
Published in PloS one (07.05.2020)
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Journal Article
Automated pH and conductivity conditioning using feedback control to support a two-step continuous purification process
Jackobek, Ryan, Herrick-Wagman, Sarah, Zhu, Lily, Francis, Christopher, Solbrand, Anita, Eriksson, Christer, Berg, Mikael, Go, Daniel, D'Antona, Aaron M
Published in Journal of Chromatography A (25.10.2020)
Published in Journal of Chromatography A (25.10.2020)
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Journal Article
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation
D'Antona, Aaron M., Ahn, Kwang H., Wang, Lei, Mierke, Dale F., Lucas-Lenard, Jean, Kendall, Debra A.
Published in Brain research (07.09.2006)
Published in Brain research (07.09.2006)
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Journal Article
New Opportunities in Glycan Engineering for Therapeutic Proteins
Zhong, Xiaotian, D'Antona, Aaron M, Scarcelli, John J, Rouse, Jason C
Published in Antibodies (Basel) (10.01.2022)
Published in Antibodies (Basel) (10.01.2022)
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Journal Article
Parallel loading and complete automation of a 3-step mAb purification process for multiple samples using a customized preparative chromatography instrument with networked pumps
Ferguson, Darren E., Mahan, Evan R., Ma, Weijun, Bitzas, Gabrielle, Zhong, Xiaotian, Zollner, Richard, D’Antona, Aaron M.
Published in Journal of Chromatography A (23.03.2018)
Published in Journal of Chromatography A (23.03.2018)
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Journal Article
Assembly of an Activated Rhodopsin–Transducin Complex in Nanoscale Lipid Bilayers
D’Antona, Aaron M, Xie, Guifu, Sligar, Stephen G, Oprian, Daniel D
Published in Biochemistry (Easton) (14.01.2014)
Published in Biochemistry (Easton) (14.01.2014)
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Journal Article
Exploring Parametric and Mechanistic Differences between Expi293FTM and ExpiCHO-STM Cells for Transient Antibody Production Optimization
Zhou, Jing, Yan, Guoying Grace, Cluckey, David, Meade, Caryl, Ruth, Margaret, Sorm, Rhady, Tam, Amy S., Lim, Sean, Petridis, Constantine, Lin, Laura, D’Antona, Aaron M., Zhong, Xiaotian
Published in Antibodies (Basel) (10.08.2023)
Published in Antibodies (Basel) (10.08.2023)
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Journal Article
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors
Root, Adam R, Guntas, Gurkan, Katragadda, Madan, Apgar, James R, Narula, Jatin, Chang, Chew Shun, Hanscom, Sara, McKenna, Matthew, Wade, Jason, Meade, Caryl, Ma, Weijun, Guo, Yongjing, Liu, Yan, Duan, Weili, Hendershot, Claire, King, Amy C, Zhang, Yan, Sousa, Eric, Tam, Amy, Benard, Susan, Yang, Han, Kelleher, Kerry, Jin, Fang, Piche-Nicholas, Nicole, Keating, Sinead E, Narciandi, Fernando, Lawrence-Henderson, Rosemary, Arai, Maya, Stochaj, Wayne R, Svenson, Kristine, Mosyak, Lidia, Lam, Khetemcnee, Francis, Christopher, Marquette, Kimberly, Wroblewska, Liliana, Zhu, H Lily, Sheehan, Alfredo Darmanin, LaVallie, Edward R, D'Antona, Aaron M, Betts, Alison, King, Lindsay, Rosfjord, Edward, Cunningham, Orla, Lin, Laura, Sapra, Puja, Tchistiakova, Lioudmila, Mathur, Divya, Bloom, Laird
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Exploring Parametric and Mechanistic Differences between Expi293F[sup.TM] and ExpiCHO-S[sup.TM] Cells for Transient Antibody Production Optimization
Zhou, Jing, Yan, Guoying Grace, Cluckey, David, Meade, Caryl, Ruth, Margaret, Sorm, Rhady, Tam, Amy S, Lim, Sean, Petridis, Constantine, Lin, Laura, D’Antona, Aaron M, Zhong, Xiaotian
Published in Antibodies (Basel) (01.09.2023)
Published in Antibodies (Basel) (01.09.2023)
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Journal Article
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer
Root, Adam, Cao, Wei, Li, Bilian, LaPan, Peter, Meade, Caryl, Sanford, Jocelyn, Jin, Macy, O’Sullivan, Cliona, Cummins, Emma, Lambert, Matthew, Sheehan, Alfredo, Ma, Weijun, Gatto, Scott, Kerns, Kelvin, Lam, Khetemenee, D’Antona, Aaron, Zhu, Lily, Brady, William, Benard, Susan, King, Amy, He, Tao, Racie, Lisa, Arai, Maya, Barrett, Dianah, Stochaj, Wayne, LaVallie, Edward, Apgar, James, Svenson, Kristine, Mosyak, Lidia, Yang, Yinhua, Chichili, Gurunadh, Liu, Liqin, Li, Hua, Burke, Steve, Johnson, Syd, Alderson, Ralph, Finlay, William, Lin, Laura, Olland, Stéphane, Somers, William, Bonvini, Ezio, Gerber, Hans-Peter, May, Chad, Moore, Paul, Tchistiakova, Lioudmila, Bloom, Laird
Published in Antibodies (Basel) (04.03.2016)
Published in Antibodies (Basel) (04.03.2016)
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Journal Article
Preparation of an Activated Rhodopsin/Transducin Complex Using a Constitutively Active Mutant of Rhodopsin
Xie, Guifu, D’Antona, Aaron M, Edwards, Patricia C, Fransen, Maikel, Standfuss, Jorg, Schertler, Gebhard F. X, Oprian, Daniel D
Published in Biochemistry (Easton) (29.11.2011)
Published in Biochemistry (Easton) (29.11.2011)
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Journal Article
Large-Scale Transient Production in ExpiCHO-S™ with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection
Zhong, Xiaotian, Schwab, Ashley, Ma, Weijun, Meade, Caryl L, Zhou, Jing, D'Antona, Aaron M, Somers, Will, Lin, Laura
Published in Methods in molecular biology (Clifton, N.J.) (2022)
Published in Methods in molecular biology (Clifton, N.J.) (2022)
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Journal Article
Impacts of fast production of afucosylated antibodies and Fc mutants in ExpiCHO-S™ for enhancing FcγRIIIa binding and NK cell activation
Zhong, Xiaotian, Schenk, Jennifer, Sakorafas, Paul, Chamberland, John, Tam, Amy, Thomas, L. Michael, Yan, Grace, D’ Antona, Aaron M., Lin, Laura, Nocula-Lugowska, Malgorzata, Zhang, Yan, Sousa, Eric, Cohen, Justin, Gu, Ling, Abel, Molica, Donahue, Jacob, Lim, Sean, Meade, Caryl, Zhou, Jing, Riegel, Logan, Birch, Alex, Fennell, Brian J., Franklin, Edward, Gomes, Jose M., Tzvetkova, Boriana, Scarcelli, John J.
Published in Journal of biotechnology (10.12.2022)
Published in Journal of biotechnology (10.12.2022)
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Journal Article
Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies
Zhong, Xiaotian, Yan, Guoying Grace, Chaturvedi, Apurva, Li, Xiuling, Gao, Yijie, Girgenrath, Mahasweta, Corcoran, Chris J, Diblasio-Smith, Liz, LaVallie, Edward R, de Rham, Teresse, Zhou, Jing, Abel, Molica, Riegel, Logan, Lim, Sean K H, Bloom, Laird, Lin, Laura, D'Antona, Aaron M
Published in Antibodies (Basel) (07.10.2024)
Published in Antibodies (Basel) (07.10.2024)
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