Alternatives to antibiotics—a pipeline portfolio review
Czaplewski, Lloyd, Dr, Bax, Richard, MD, Clokie, Martha, Prof, Dawson, Mike, PhD, Fairhead, Heather, PhD, Fischetti, Vincent A, Prof, Foster, Simon, Prof, Gilmore, Brendan F, Prof, Hancock, Robert E W, Prof, Harper, David, PhD, Henderson, Ian R, Prof, Hilpert, Kai, PhD, Jones, Brian V, PhD, Kadioglu, Aras, Prof, Knowles, David, PhD, Ólafsdóttir, Sigríður, PhD, Payne, David, PhD, Projan, Steve, PhD, Shaunak, Sunil, Prof, Silverman, Jared, PhD, Thomas, Christopher M, Prof, Trust, Trevor J, PhD, Warn, Peter, PhD, Rex, John H, MD
Published in The Lancet infectious diseases (01.02.2016)
Published in The Lancet infectious diseases (01.02.2016)
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Journal Article
Letter to the Editor concerning “Prospective study using anterior approach did not show association between Modic 1 changes and low-grade infection in lumbar spine” by Rigal J, Thelen T, Byrne F, Cogniet A, Boissière L, Aunoble S, Le Huec JC (Eur Spine J [2016]; 25(4):1000–5. doi: 10.1007/s00586-016-4396-5)
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Journal Article
Multiple effects of benzamide antibiotics on FtsZ function
Adams, David W., Wu, Ling Juan, Czaplewski, Lloyd G., Errington, Jeff
Published in Molecular microbiology (01.04.2011)
Published in Molecular microbiology (01.04.2011)
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Journal Article
Chronic low back pain, bacterial infection and treatment with antibiotics
Gilligan, Christopher J., Cohen, Steven P., Fischetti, Vincent A., Hirsch, Joshua A., Czaplewski, Lloyd G.
Published in The spine journal (01.06.2021)
Published in The spine journal (01.06.2021)
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Journal Article
Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity
Haydon, David J, Stokes, Neil R, Ure, Rebecca, Galbraith, Greta, Bennett, James M, Brown, David R, Baker, Patrick J, Barynin, Vladimir V, Rice, David W, Sedelnikova, Sveta E, Heal, Jonathan R, Sheridan, Joseph M, Aiwale, Sachin T, Chauhan, Pramod K, Srivastava, Anil, Taneja, Amit, Collins, Ian, Errington, Jeff, Czaplewski, Lloyd G
Published in Science (American Association for the Advancement of Science) (19.09.2008)
Published in Science (American Association for the Advancement of Science) (19.09.2008)
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Journal Article
An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy
STOKES, Neil R, BAKER, Nicola, MITCHELL, Jeffrey P, NAYAL, Narendra, YADAV, Anju, SRIVASTAVA, Anil, HAYDON, David J, BENNETT, James M, BERRY, Joanne, COLLINS, Ian, CZAPLEWSKI, Lloyd G, LOGAN, Alastair, MACDONALD, Rebecca, MACLEOD, Leanne, PEASLEY, Hilary
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
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Journal Article
Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity
Yule, Ian A., Czaplewski, Lloyd G., Pommier, Stephanie, Davies, David T., Narramore, Sarah K., Fishwick, Colin W.G.
Published in European journal of medicinal chemistry (30.10.2014)
Published in European journal of medicinal chemistry (30.10.2014)
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Journal Article
Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ
Stokes, Neil R., Baker, Nicola, Bennett, James M., Chauhan, Pramod K., Collins, Ian, Davies, David T., Gavade, Maruti, Kumar, Dushyant, Lancett, Paul, Macdonald, Rebecca, MacLeod, Leanne, Mahajan, Anu, Mitchell, Jeffrey P., Nayal, Narendra, Nayal, Yashodanand Nandan, Pitt, Gary R. W., Singh, Mahipal, Yadav, Anju, Srivastava, Anil, Czaplewski, Lloyd G., Haydon, David J.
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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Journal Article
Reply to a letter to the editor regarding the article, “Chronic low back pain, bacterial infection and treatment with antibiotics. Gilligan CJ, Cohen SP, Fischetti VA, Hirsch JA, Czaplewski LG. Spine J 2021 Feb 18;S1529-9430”
Gilligan, Christopher J., Cohen, Steven P., Fischetti, Vincent A., Hirsch, Joshua A., Czaplewski, Lloyd G.
Published in The spine journal (01.07.2021)
Published in The spine journal (01.07.2021)
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Journal Article
Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement
Chopra, Ian, Prof, Schofield, Christopher, Prof, Everett, Martin, PhD, O'Neill, Alex, PhD, Miller, Keith, PhD, Wilcox, Mark, Prof, Frère, Jean-Marie, Prof, Dawson, Mike, PhD, Czaplewski, Lloyd, PhD, Urleb, Uros, PhD, Courvalin, Patrice, Prof
Published in The Lancet infectious diseases (01.02.2008)
Published in The Lancet infectious diseases (01.02.2008)
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Journal Article
Conference Proceeding
Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration
Hagger, Graham, Guest, Sarah, Birchall, Stephen, Bradley, Alys, Brindley, Charlie, Corbett, David, Cummings, Paul J, Freire, Cristina, Harris, James, Wise, Andrew, Wood, Melanie, Czaplewski, Lloyd G
Published in JOR-spine (01.12.2024)
Published in JOR-spine (01.12.2024)
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Journal Article
Biological Evaluation of Benzothiazole Ethyl Urea Inhibitors of Bacterial Type II Topoisomerases
STOKES, Neil R, THOMAIDES-BREARS, Helena B, LUNNISS, Christopher J, PEASLEY, Hilary, POMMIER, Stéphanie, PRICE, Daniel, SMEE, Carol, HAYDON, David J, BARKER, Stephanie, BENNETT, James M, BERRY, Joanne, COLLINS, Ian, CZAPLEWSKI, Lloyd G, GAMBLE, Vicki, LANCETT, Paul, LOGAN, Alastair
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Journal Article
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ
Czaplewski, Lloyd G., Collins, Ian, Boyd, E. Andrew, Brown, David, East, Stephen P., Gardiner, Mihaly, Fletcher, Rowena, Haydon, David J., Henstock, Vincent, Ingram, Peter, Jones, Clare, Noula, Caterina, Kennison, Leanne, Rockley, Chris, Rose, Valerie, Thomaides-Brears, Helena B., Ure, Rebecca, Whittaker, Mark, Stokes, Neil R.
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Journal Article
Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors
Axford, Lorraine C., Agarwal, Piyush K., Anderson, Kelly H., Andrau, Laura N., Atherall, John, Barker, Stephanie, Bennett, James M., Blair, Michael, Collins, Ian, Czaplewski, Lloyd G., Davies, David T., Gannon, Carlie T., Kumar, Dushyant, Lancett, Paul, Logan, Alastair, Lunniss, Christopher J., Mitchell, Dale R., Offermann, Daniel A., Palmer, James T., Palmer, Nicholas, Pitt, Gary R.W., Pommier, Stéphanie, Price, Daniel, Narasinga Rao, B., Saxena, Rashmi, Shukla, Tarun, Singh, Amit K., Singh, Mahipal, Srivastava, Anil, Steele, Christopher, Stokes, Neil R., Thomaides-Brears, Helena B., Tyndall, Edward M., Watson, David, Haydon, David J.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening Assay
Stokes, Neil R., Sievers, Jörg, Barker, Stephanie, Bennett, James M., Brown, David R., Collins, Ian, Errington, Veronica M., Foulger, David, Hall, Michelle, Halsey, Rowena, Johnson, Hazel, Rose, Valerie, Thomaides, Helena B., Haydon, David J., Czaplewski, Lloyd G., Errington, Jeff
Published in The Journal of biological chemistry (02.12.2005)
Published in The Journal of biological chemistry (02.12.2005)
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Journal Article
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
East, Stephen P., White, Clara Bantry, Barker, Oliver, Barker, Stephanie, Bennett, James, Brown, David, Boyd, E. Andrew, Brennan, Christopher, Chowdhury, Chandana, Collins, Ian, Convers-Reignier, Emmanuelle, Dymock, Brian W., Fletcher, Rowena, Haydon, David J., Gardiner, Mihaly, Hatcher, Stuart, Ingram, Peter, Lancett, Paul, Mortenson, Paul, Papadopoulos, Konstantinos, Smee, Carol, Thomaides-Brears, Helena B., Tye, Heather, Workman, James, Czaplewski, Lloyd G.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Essential Bacterial Functions Encoded by Gene Pairs
THOMAIDES, Helena B, DAVISON, Ella J, BURSTON, Lisa, JOHNSON, Hazel, BROWN, David R, HUNT, Alison C, ERRINGTON, Jeffery, CZAPLEWSKI, Lloyd
Published in Journal of Bacteriology (01.01.2007)
Published in Journal of Bacteriology (01.01.2007)
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Journal Article
Discovery and development of new antibacterial drugs: learning from experience?
Jackson, Nicole, Czaplewski, Lloyd, Piddock, Laura J V
Published in Journal of antimicrobial chemotherapy (01.06.2018)
Published in Journal of antimicrobial chemotherapy (01.06.2018)
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Journal Article
The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity
Trkola, A, Gordon, C, Matthews, J, Maxwell, E, Ketas, T, Czaplewski, L, Proudfoot, A E, Moore, J P
Published in Journal of Virology (01.08.1999)
Published in Journal of Virology (01.08.1999)
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