Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer
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Published in Molecular cancer therapeutics (01.05.2018)
Published in Molecular cancer therapeutics (01.05.2018)
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Optimization of a Novel Binding Motif to (E)‑3-(3,5-Difluoro-4-((1R,3R)‑2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro‑1H‑pyrido[3,4‑b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist
De Savi, Chris, Bradbury, Robert H, Rabow, Alfred A, Norman, Richard A, de Almeida, Camila, Andrews, David M, Ballard, Peter, Buttar, David, Callis, Rowena J, Currie, Gordon S, Curwen, Jon O, Davies, Chris D, Donald, Craig S, Feron, Lyman J. L, Gingell, Helen, Glossop, Steven C, Hayter, Barry R, Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G, MacFaul, Philip, Moss, Thomas A, Pearson, Stuart E, Tonge, Michael, Walker, Graeme E, Weir, Hazel M, Wilson, Zena
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib
Rolf, Michael G., Curwen, Jon O., Veldman‐Jones, Margaret, Eberlein, Cath, Wang, Jianyan, Harmer, Alex, Hellawell, Caroline J., Braddock, Martin
Published in Pharmacology research & perspectives (01.10.2015)
Published in Pharmacology research & perspectives (01.10.2015)
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Inhibition of Vascular Endothelial Growth Factor-A Signaling Induces Hypertension: Examining the Effect of Cediranib (Recentin; AZD2171) Treatment on Blood Pressure in Rat and the Use of Concomitant Antihypertensive Therapy
Curwen, Jon O, Musgrove, Helen L, Kendrew, Jane, Richmond, Graham H P, Ogilvie, Donald J, Wedge, Stephen R
Published in Clinical cancer research (15.05.2008)
Published in Clinical cancer research (15.05.2008)
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Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
Hennequin, Laurent F, Thomas, Andrew P, Johnstone, Craig, Stokes, Elaine S. E, Plé, Patrick A, Lohmann, Jean-Jacques M, Ogilvie, Donald J, Dukes, Mike, Wedge, Steve R, Curwen, Jon O, Kendrew, Jane, Lambert-van der Brempt, Christine
Published in Journal of medicinal chemistry (30.12.1999)
Published in Journal of medicinal chemistry (30.12.1999)
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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Weir, Hazel M, Bradbury, Robert H, Lawson, Mandy, Rabow, Alfred A, Buttar, David, Callis, Rowena J, Curwen, Jon O, de Almeida, Camila, Ballard, Peter, Hulse, Michael, Donald, Craig S, Feron, Lyman J L, Karoutchi, Galith, MacFaul, Philip, Moss, Thomas, Norman, Richard A, Pearson, Stuart E, Tonge, Michael, Davies, Gareth, Walker, Graeme E, Wilson, Zena, Rowlinson, Rachel, Powell, Steve, Sadler, Claire, Richmond, Graham, Ladd, Brendon, Pazolli, Ermira, Mazzola, Anne Marie, D'Cruz, Celina, De Savi, Chris
Published in Cancer research (Chicago, Ill.) (01.06.2016)
Published in Cancer research (Chicago, Ill.) (01.06.2016)
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Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)
Degorce, Sébastien L, Boyd, Scott, Curwen, Jon O, Ducray, Richard, Halsall, Christopher T, Jones, Clifford D, Lach, Franck, Lenz, Eva M, Pass, Martin, Pass, Sarah, Trigwell, Catherine
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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AZD2171 : A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
WEDGE, Stephen R, KENDREW, Jane, CHESTER, Rosemary, JACKSON, Janet A, BOFFEY, Sarah J, KILBURN, Lyndsey L, BARNETT, Sharon, RICHMOND, Graham H. P, WADSWORTH, Peter F, WALKER, Mike, BIGLEY, Alison L, TAYLOR, Sian T, HENNEQUIN, Laurent F, COOPER, Lee, BECK, Sarah, JÜRGENSMEIER, Juliane M, OGILVIE, Donald J, VALENTINE, Paula J, BARRY, Simon T, BRAVE, Sandra R, SMITH, Neil R, JAMES, Neil H, DUKES, Michael, CURWEN, Jon O
Published in Cancer research (Chicago, Ill.) (15.05.2005)
Published in Cancer research (Chicago, Ill.) (15.05.2005)
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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors
Hennequin, Laurent F, Stokes, Elaine S. E, Thomas, Andrew P, Johnstone, Craig, Plé, Patrick A, Ogilvie, Donald J, Dukes, Michael, Wedge, Stephen R, Kendrew, Jane, Curwen, Jon O
Published in Journal of medicinal chemistry (14.03.2002)
Published in Journal of medicinal chemistry (14.03.2002)
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ZD4190 : An orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy
WEDGE, S. R, OGILVIE, D. J, WADSWORTH, P. F, DUKES, M, KENDREW, J, CURWEN, J. O, HENNEQUIN, L. F, THOMAS, A. P, STOKES, E. S. E, CURRY, B, RICHMOND, G. H. P
Published in Cancer research (Chicago, Ill.) (15.02.2000)
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Published in Cancer research (Chicago, Ill.) (15.02.2000)
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Effect of Pretreatment With Atenolol and Nifedipine on ZD6126-Induced Cardiac Toxicity in Rats
Gould, Sarah, Westwood, F. Russell, Curwen, Jon O., Ashton, Susan E., Roberts, David W., Lovick, Susan C., Ryan, Anderson J.
Published in JNCI : Journal of the National Cancer Institute (21.11.2007)
Published in JNCI : Journal of the National Cancer Institute (21.11.2007)
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Optimization of a Novel Binding Motif to ( E )-3-(3,5-Difluoro-4-((1 R ,3 R )-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1 H -pyrido[3,4- b ]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist
De Savi, Chris, Bradbury, Robert H., Rabow, Alfred A., Norman, Richard A., de Almeida, Camila, Andrews, David M., Ballard, Peter, Buttar, David, Callis, Rowena J., Currie, Gordon S., Curwen, Jon O., Davies, Chris D., Donald, Craig S., Feron, Lyman J. L., Gingell, Helen, Glossop, Steven C., Hayter, Barry R., Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G., MacFaul, Philip, Moss, Thomas A., Pearson, Stuart E., Tonge, Michael, Walker, Graeme E., Weir, Hazel M., Wilson, Zena
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Journal Article
Effect of Pretreatment With Atenolol and Nifedipine on ZD6126-lnduced Cardiac Toxicity in Rats
GOULD, Sarah, WESTWOOD, F. Russell, CURWEN, Jon O, ASHTON, Susan E, ROBERTS, David W, LOVICK, Susan C, RYAN, Anderson J
Published in JNCI : Journal of the National Cancer Institute (2007)
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Published in JNCI : Journal of the National Cancer Institute (2007)
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Therapeutic treatment
BOYLE FRANCIS T, CURWEN JON O, HUGHES ANDREW M, TAYLOR SIAN T, HANCOX URSULA J, TONGE DAVID W, GALLAGHER NEIL J, JOHNSTONE DONNA
Year of Publication 08.06.2006
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Year of Publication 08.06.2006
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