Substituent effects on aryltrifluoroborate solvolysis in water: implications for Suzuki-Miyaura coupling and the design of stable (18)F-labeled aryltrifluoroborates for use in PET imaging
Ting, Richard, Harwig, Curtis W, Lo, Justin, Li, Ying, Adam, Michael J, Ruth, Thomas J, Perrin, David M
Published in Journal of organic chemistry (20.06.2008)
Published in Journal of organic chemistry (20.06.2008)
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P32 - Comparative metabolism of 14C-AQX-1125 following oral administration to rats, dogs and humans
Barton, Eleanor, Cooke, Ray, Williams, Dylan, Tam, Patrick, Toews, Judy, Harwig, Curtis, Pettigrew, Jeremy, Scholl, Dorothea, Padania, Sapna, Mackenzie, Lloyd
Published in Drug metabolism and pharmacokinetics (2020)
Published in Drug metabolism and pharmacokinetics (2020)
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Novel Matrix Metalloproteinase Inhibitor [18F]Marimastat-Aryltrifluoroborate as a Probe for In vivo Positron Emission Tomography Imaging in Cancer
AUF DEM KELLER, Ulrich, BELLAC, Caroline L, RUTH, Thomas J, BENARD, François, PERRIN, David M, OVERALL, Christopher M, YING LI, YUANMEI LOU, LANGE, Philipp F, RICHARD TING, HARWIG, Curtis, KAPPELHOFF, Reinhild, DEDHAR, Shoukat, ADAM, Michael J
Published in Cancer research (Chicago, Ill.) (01.10.2010)
Published in Cancer research (Chicago, Ill.) (01.10.2010)
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P31 - Rates and routes of excretion of 14C-AQX-1125 following oral administration to rats, dogs and humans
Cooke, Ray, Bond, Philip, Barton, Eleanor, Shaw, Iain, Tam, Patrick, Toews, Judy, Harwig, Curtis, Pettigrew, Jeremy, Scholl, Dorothea, Padania, Sapna, Mackenzie, Lloyd
Published in Drug metabolism and pharmacokinetics (2020)
Published in Drug metabolism and pharmacokinetics (2020)
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Characterization of AQX‐1125, a small‐molecule SHIP1 activator
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Wu, Joyce, Ogden, Nancy, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Characterization of AQX‐1125, a small‐molecule SHIP1 activator
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Chernoff, David, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Journal Article
Substituent Effects on Aryltrifluoroborate Solvolysis in Water: Implications for Suzuki−Miyaura Coupling and the Design of Stable 18F-Labeled Aryltrifluoroborates for Use in PET Imaging
Ting, Richard, Harwig, Curtis W, Lo, Justin, Li, Ying, Adam, Michael J, Ruth, Thomas J, Perrin, David M
Published in Journal of organic chemistry (20.06.2008)
Published in Journal of organic chemistry (20.06.2008)
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Journal Article
Conversion of Enediynes into Quinones by Antibody Catalysis and in Aqueous Buffers: Implications for an Alternative Enediyne Therapeutic Mechanism
Jones, Lyn H, Harwig, Curtis W, Wentworth, Paul, Simeonov, Anton, Wentworth, Anita D, Py, Sandrine, Ashley, Jon A, Lerner, Richard A, Janda, Kim D
Published in Journal of the American Chemical Society (18.04.2001)
Published in Journal of the American Chemical Society (18.04.2001)
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MP39-13 AN OPEN-LABEL, TWO-PART, SEQUENTIAL DOSE STUDY ASSESSING THE ABSOLUTE BIOAVAILABILITY, MASS BALANCE, AND RECOVERY FOR [14C]-ROSIPTOR (AQX-1125) IN HEALTHY SUBJECTS
Tam, Patrick, Scholl, Dorothea, Toews, Judy, Harwig, Curtis, Mackenzie, Lloyd F
Published in The Journal of urology (01.04.2018)
Published in The Journal of urology (01.04.2018)
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Taxamycins: a new enediyne family constructed from versatile disilyl-substituted building blocks
Lu, Yee Fung, Harwig, Curtis W, Fallis, Alex G
Published in Journal of organic chemistry (01.07.1993)
Published in Journal of organic chemistry (01.07.1993)
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AQX‐1125, small molecule SHIP1 activator inhibits bleomycin‐induced pulmonary fibrosis
Cross, Jennifer, Stenton, Grant R, Harwig, Curtis, Szabo, Csaba, Genovese, Tiziana, Di Paola, Rosanna, Esposito, Emanuale, Cuzzocrea, Salvatore, Mackenzie, Lloyd F
Published in British journal of pharmacology (01.09.2017)
Published in British journal of pharmacology (01.09.2017)
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Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases
Li, Ying, Ting, Richard, Harwig, Curtis W., auf dem Keller, Ulrich, Bellac, Caroline L., Lange, Philipp F., Inkster, James A. H., Schaffer, Paul, Adam, Michael J., Ruth, Thomas J., Overall, Christopher M., Perrin, David M.
Published in MedChemComm (2011)
Published in MedChemComm (2011)
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Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells
Lemm, Elizabeth A, Valle-Argos, Beatriz, Smith, Lindsay D, Richter, Johanna, Gebreselassie, Yohannes, Carter, Matthew J, Karolova, Jana, Svaton, Michael, Helman, Karel, Weston-Bell, Nicola J, Karydis, Laura, Williamson, Chris T, Lenz, Georg, Pettigrew, Jeremy, Harwig, Curtis, Stevenson, Freda K, Cragg, Mark, Forconi, Francesco, Steele, Andrew J, Cross, Jennifer, Mackenzie, Lloyd, Klener, Pavel, Packham, Graham
Published in Clinical cancer research (01.04.2020)
Published in Clinical cancer research (01.04.2020)
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Toward [18F]-Labeled Aryltrifluoroborate Radiotracers: In Vivo Positron Emission Tomography Imaging of Stable Aryltrifluoroborate Clearance in Mice
Ting, Richard, Harwig, Curtis, auf dem Keller, Ulrich, McCormick, Siobhan, Austin, Pamela, Overall, Christopher M, Adam, Michael J, Ruth, Thomas J, Perrin, David M
Published in Journal of the American Chemical Society (10.09.2008)
Published in Journal of the American Chemical Society (10.09.2008)
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Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Wu, Joyce, Ogden, Nancy, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Taxamycin Studies: CrCl2/NiCl2-Mediated Cyclizations and Unusual SeO2 Oxidations
Harwig, Curtis W, Py, Sandrine, Fallis, Alex G
Published in Journal of organic chemistry (14.11.1997)
Published in Journal of organic chemistry (14.11.1997)
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Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Chernoff, David, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication
Skerlj, Renato T, Bridger, Gary J, Kaller, Al, McEachern, Ernest J, Crawford, Jason B, Zhou, Yuanxi, Atsma, Bem, Langille, Jonathon, Nan, Susan, Veale, Duane, Wilson, Trevor, Harwig, Curtis, Hatse, Sigrid, Princen, Katrien, De Clercq, Erik, Schols, Dominique
Published in Journal of medicinal chemistry (22.04.2010)
Published in Journal of medicinal chemistry (22.04.2010)
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