High‐resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers
Dent, Barry M., Ogle, Laura F., O'Donnell, Rachel L., Hayes, Nicholas, Malik, Ujjal, Curtin, Nicola J., Boddy, Alan V., Plummer, E. Ruth, Edmondson, Richard J., Reeves, Helen L., May, Felicity E.B., Jamieson, David
Published in International journal of cancer (01.01.2016)
Published in International journal of cancer (01.01.2016)
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mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition
Massey, Andrew J., Stephens, Peter, Rawlinson, Rebecca, McGurk, Lauren, Plummer, Ruth, Curtin, Nicola J.
Published in Molecular oncology (01.01.2016)
Published in Molecular oncology (01.01.2016)
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Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
Tavecchio, Michele, Munck, Joanne M., Cano, Celine, Newell, David R., Curtin, Nicola J.
Published in Cancer chemotherapy and pharmacology (2012)
Published in Cancer chemotherapy and pharmacology (2012)
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Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer
Unterlass, Judith E, Baslé, Arnaud, Blackburn, Timothy J, Tucker, Julie, Cano, Céline, Noble, Martin E M, Curtin, Nicola J
Published in Oncotarget (02.03.2018)
Published in Oncotarget (02.03.2018)
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Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors
Kotsopoulos, Ioannis C, Kucukmetin, Ali, Mukhopadhyay, Asima, Lunec, John, Curtin, Nicola J
Published in International journal of gynecological cancer (01.05.2016)
Published in International journal of gynecological cancer (01.05.2016)
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6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance
ISSAEVA, Natalia, THOMAS, Huw D, CHATZAKOS, Vicky, MULLIGAN, Evan A, LUNDIN, Cecilia, GUBANOVA, Evgenia, KERSBERGEN, Ariena, HARRIS, Adrian L, SHARMA, Ricky A, ROTTENBERG, Sven, CURTIN, Nicola J, HELLEDAY, Thomas, DJURENOVIC, Tatjana, JASPERS, Janneke E, STOIMENOV, Ivaylo, KYLE, Suzanne, PEDLEY, Nicholas, GOTTIPATI, Ponnari, ZUR, Rafal, SLEETH, Kate
Published in Cancer research (Chicago, Ill.) (01.08.2010)
Published in Cancer research (Chicago, Ill.) (01.08.2010)
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Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells
King, David, Southgate, Harriet E D, Roetschke, Saskia, Gravells, Polly, Fields, Leona, Watson, Jessica B, Chen, Lindi, Chapman, Devon, Harrison, Daniel, Yeomanson, Daniel, Curtin, Nicola J, Tweddle, Deborah A, Bryant, Helen E
Published in Cancers (10.12.2021)
Published in Cancers (10.12.2021)
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Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)
Unterlass, Judith E, Wood, Robert J, Baslé, Arnaud, Tucker, Julie, Cano, Céline, Noble, Martin M E, Curtin, Nicola J
Published in Oncotarget (28.11.2017)
Published in Oncotarget (28.11.2017)
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The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice
Ali, Majid, Kamjoo, Marzieh, Thomas, Huw D, Kyle, Suzanne, Pavlovska, Ivanda, Babur, Muhammed, Telfer, Brian A, Curtin, Nicola J, Williams, Kaye J
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
VEUGER, Stephany J, CURTIN, Nicola J, RICHARDSON, Caroline J, SMITH, Graeme C. M, DURKACZ, Barbara W
Published in Cancer research (Chicago, Ill.) (15.09.2003)
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Published in Cancer research (Chicago, Ill.) (15.09.2003)
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1‑Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino‑4H‑chromen-4-ones Endowed with Dual DNA-PK/PI3‑K Inhibitory Activity
Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Menear, Keith A, Newell, David R, Richardson, Caroline J, Shea, K, Smith, Graeme C. M, Thommes, Pia, Ting, Attilla, Griffin, Roger J
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Journal Article
PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS
Almeida, Gilberto S., Bawn, Carlo M., Galler, Martin, Wilson, Ian, Thomas, Huw D., Kyle, Suzanne, Curtin, Nicola J., Newell, David R., Maxwell, Ross J.
Published in NMR in biomedicine (01.09.2017)
Published in NMR in biomedicine (01.09.2017)
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Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines
Clarke, Michelle J, Mulligan, Evan A, Grogan, Patrick T, Mladek, Ann C, Carlson, Brett L, Schroeder, Mark A, Curtin, Nicola J, Lou, Zhenkun, Decker, Paul A, Wu, Wenting, Plummer, E Ruth, Sarkaria, Jann N
Published in Molecular cancer therapeutics (01.02.2009)
Published in Molecular cancer therapeutics (01.02.2009)
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Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies
Gaymes, Terry J, Mohamedali, Azim M, Patterson, Miranda, Matto, Nazia, Smith, Alexander, Kulasekararaj, Austin, Chelliah, Rajani, Curtin, Nicola, Farzaneh, Farzin, Shall, Sydney, Mufti, Ghulam J
Published in Haematologica (Roma) (01.09.2013)
Published in Haematologica (Roma) (01.09.2013)
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The Novel Poly(ADP-Ribose) Polymerase Inhibitor, AG14361, Sensitizes Cells to Topoisomerase I Poisons by Increasing the Persistence of DNA Strand Breaks
Smith, Lisa M, Willmore, Elaine, Austin, Caroline A, Curtin, Nicola J
Published in Clinical cancer research (01.12.2005)
Published in Clinical cancer research (01.12.2005)
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PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia
Herriott, Ashleigh, Tudhope, Susan J, Junge, Gesa, Rodrigues, Natalie, Patterson, Miranda J, Woodhouse, Laura, Lunec, John, Hunter, Jill E, Mulligan, Evan A, Cole, Michael, Allinson, Lisa M, Wallis, Jonathan P, Marshall, Scott, Wang, Evelyn, Curtin, Nicola J, Willmore, Elaine
Published in Oncotarget (22.12.2015)
Published in Oncotarget (22.12.2015)
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Development of pharmacodynamic biomarkers for ATR inhibitors
Chen, Tao, Middleton, Fiona K., Falcon, Susanna, Reaper, Philip M., Pollard, John R., Curtin, Nicola J.
Published in Molecular oncology (01.02.2015)
Published in Molecular oncology (01.02.2015)
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Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach
Hardcastle, Ian R, Cockcroft, Xiaoling, Curtin, Nicola J, El-Murr, Marine Desage, Leahy, Justin J. J, Stockley, Martin, Golding, Bernard T, Rigoreau, Laurent, Richardson, Caroline, Smith, Graeme C. M, Griffin, Roger J
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
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Inhibition of Poly(ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma
DANIEL, Rachel A, ROZANSKA, Agata L, CURTIN, Nicola J, CLIFFORD, Steven C, THOMAS, Huw D, MULLIGAN, Evan A, DREW, Yvette, CASTELBUONO, Deborah J, HOSTOMSKY, Zdenek, PLUMMER, E. Ruth, BODDY, Alan V, TWEDDLE, Deborah A
Published in Clinical cancer research (15.02.2009)
Published in Clinical cancer research (15.02.2009)
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