sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2019)
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Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate
Castro, Joel, Harrington, Andrea M, Hughes, Patrick A, Martin, Christopher M, Ge, Pei, Shea, Courtney M, Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B, MacDougall, James E, Lavins, Bernard J, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Johnston, Jeffrey M, Currie, Mark G, Blackshaw, L. Ashley, Brierley, Stuart M
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2013)
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Two Randomized Trials of Linaclotide for Chronic Constipation
Lembo, Anthony J, Schneier, Harvey A, Shiff, Steven J, Kurtz, Caroline B, MacDougall, James E, Jia, Xinwei D, Shao, James Z, Lavins, Bernard J, Currie, Mark G, Fitch, Donald A, Jeglinski, Brenda I, Eng, Paul, Fox, Susan M, Johnston, Jeffrey M
Published in The New England journal of medicine (11.08.2011)
Published in The New England journal of medicine (11.08.2011)
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Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
Schoenfeld, Philip, Lacy, Brian E, Chey, William D, Lembo, Anthony J, Kurtz, Caroline B, Reasner, David S, Bochenek, Wieslaw, Tripp, Kenneth, Currie, Mark G, Fox, Susan M, Blakesley, Rick E, OʼDea, Christopher R, Omniewski, Nicholas D, Hall, Michael L
Published in The American journal of gastroenterology (01.01.2018)
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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
Busby, Robert W., Bryant, Alexander P., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Mahajan-Miklos, Shalina, Pierce, Christine M., Solinga, Robert M., Sun, Li Jing, Tobin, Jenny V., Kurtz, Caroline B., Currie, Mark G.
Published in European journal of pharmacology (15.12.2010)
Published in European journal of pharmacology (15.12.2010)
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The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system
Correia, Susana S, Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G, Tobin, Jenny V, Schwartzkopf, Chad D, Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R, Currie, Mark G, Hadcock, John R, Winrow, Christopher J, Jones, Juli E
Published in Journal of neuroinflammation (18.09.2021)
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Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial
Lacy, Brian E, Schey, Ron, Shiff, Steven J, Lavins, Bernard J, Fox, Susan M, Jia, Xinwei D, Blakesley, Rick E, Hao, Xinming, Cronin, Jacquelyn A, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M, Lembo, Anthony J
Published in PloS one (29.07.2015)
Published in PloS one (29.07.2015)
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The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases
Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.
Published in Frontiers in pharmacology (24.05.2021)
Published in Frontiers in pharmacology (24.05.2021)
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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in Frontiers in pharmacology (08.04.2020)
Published in Frontiers in pharmacology (08.04.2020)
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A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
Hansel, Trevor T, Kharitonov, Sergei A, Donnelly, Louise E, Erin, Edward M, Currie, Mark G, Moore, William M, Manning, Pamela T, Recker, David P, Barnes, Peter J
Published in The FASEB journal (01.07.2003)
Published in The FASEB journal (01.07.2003)
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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats
Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.
Published in Pharmacology research & perspectives (01.04.2020)
Published in Pharmacology research & perspectives (01.04.2020)
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FAAH inhibitor URB597 shows anti-hyperalgesic action and increases brain and intestinal tissues fatty acid amides in a model of CRF 1 agonist mediated visceral hypersensitivity in male rats
Larauche, Muriel, Mulak, Agata, Ha, Chrysanthy, Million, Mulugeta, Arnett, Stacy, Germano, Peter, Pearson, James P, Currie, Mark G, Taché, Yvette
Published in Neurogastroenterology and motility (30.09.2024)
Published in Neurogastroenterology and motility (30.09.2024)
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FAAH inhibitor URB597 shows anti-hyperalgesic action and increases brain and intestinal tissues fatty acid amides in a model of CRF1 agonist mediated visceral hypersensitivity in male rats
Larauche, Muriel, Mulak, Agata, Ha, Chrysanthy, Million, Mulugeta, Arnett, Stacy, Germano, Peter, Pearson, James P, Currie, Mark G, Taché, Yvette
Published in Neurogastroenterology and motility (30.09.2024)
Published in Neurogastroenterology and motility (30.09.2024)
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Differential Bile Acid Detection in Refractory GERD Patient Saliva Using a Simple and Sensitive Liquid Chromatography Tandem Mass Spectrometry Approach
Perez, Nisha, Chambert, Kimberly, Ribadeneira, Maria, Currie, Mark G, Chen, Yan, Kessler, Marco M
Published in Journal of clinical gastroenterology (01.03.2022)
Published in Journal of clinical gastroenterology (01.03.2022)
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Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure
Shea, Courtney M, Price, Gavrielle M, Liu, Guang, Sarno, Renee, Buys, Emmanuel S, Currie, Mark G, Masferrer, Jaime L
Published in American journal of physiology. Renal physiology (01.01.2020)
Published in American journal of physiology. Renal physiology (01.01.2020)
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Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety
CHEY, William D, LEMBO, Anthony J, BAIRD, Mollie J, SCHNEIER, Harvey A, JOHNSTON, Jeffrey M, LAVINS, Bernard J, SHIFF, Steven J, KURTZ, Caroline B, CURRIE, Mark G, MACDOUGALL, James E, JIA, Xinwei D, SHAO, James Z, FITCH, Donald A
Published in The American journal of gastroenterology (01.11.2012)
Published in The American journal of gastroenterology (01.11.2012)
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A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation
RAO, Satish, LEMBO, Anthony J, FOX, Susan M, SCHNEIER, Harvey A, KURTZ, Caroline B, JOHNSTON, Jeffrey M, SHIFF, Steven J, LAVINS, Bernard J, CURRIE, Mark G, JIA, Xinwei D, SHI, Kelvin, MACDOUGALL, James E, SHAO, James Z, ENG, Paul
Published in The American journal of gastroenterology (01.11.2012)
Published in The American journal of gastroenterology (01.11.2012)
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