Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
Disch, Jeremy S, Evindar, Ghotas, Chiu, Cynthia H, Blum, Charles A, Dai, Han, Jin, Lei, Schuman, Eli, Lind, Kenneth E, Belyanskaya, Svetlana L, Deng, Jianghe, Coppo, Frank, Aquilani, Leah, Graybill, Todd L, Cuozzo, John W, Lavu, Siva, Mao, Cheney, Vlasuk, George P, Perni, Robert B
Published in Journal of medicinal chemistry (09.05.2013)
Published in Journal of medicinal chemistry (09.05.2013)
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Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
Litovchick, Alexander, Dumelin, Christoph E., Habeshian, Sevan, Gikunju, Diana, Guié, Marie-Aude, Centrella, Paolo, Zhang, Ying, Sigel, Eric A., Cuozzo, John W., Keefe, Anthony D., Clark, Matthew A.
Published in Scientific reports (10.06.2015)
Published in Scientific reports (10.06.2015)
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Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists
Kollmann, Christopher S., Bai, Xiaopeng, Tsai, Ching-Hsuan, Yang, Hongfang, Lind, Kenneth E., Skinner, Steven R., Zhu, Zhengrong, Israel, David I., Cuozzo, John W., Morgan, Barry A., Yuki, Koichi, Xie, Can, Springer, Timothy A., Shimaoka, Motomu, Evindar, Ghotas
Published in Bioorganic & medicinal chemistry (01.04.2014)
Published in Bioorganic & medicinal chemistry (01.04.2014)
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Opportunities and challenges of Standard Model production cross section measurements in proton-proton collisions at √ s =8 TeV using CMS Open Data
Apyan, A., Cuozzo, W., Klute, M., Saito, Y., Schott, M., Sintayehu, B.
Published in Journal of instrumentation (14.01.2020)
Published in Journal of instrumentation (14.01.2020)
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Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry
Cuozzo, John W, Clark, Matthew A, Keefe, Anthony D, Kohlmann, Anna, Mulvihill, Mark, Ni, Haihong, Renzetti, Louis M, Resnicow, Daniel I, Ruebsam, Frank, Sigel, Eric A, Thomson, Heather A, Wang, Ce, Xie, Zhifeng, Zhang, Ying
Published in Journal of medicinal chemistry (23.07.2020)
Published in Journal of medicinal chemistry (23.07.2020)
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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding
McCloskey, Kevin, Sigel, Eric A, Kearnes, Steven, Xue, Ling, Tian, Xia, Moccia, Dennis, Gikunju, Diana, Bazzaz, Sana, Chan, Betty, Clark, Matthew A, Cuozzo, John W, Guié, Marie-Aude, Guilinger, John P, Huguet, Christelle, Hupp, Christopher D, Keefe, Anthony D, Mulhern, Christopher J, Zhang, Ying, Riley, Patrick
Published in Journal of medicinal chemistry (27.08.2020)
Published in Journal of medicinal chemistry (27.08.2020)
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Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target
Brown, Dean G., Brown, Giles A., Centrella, Paolo, Certel, Kaan, Cooke, Robert M., Cuozzo, John W., Dekker, Niek, Dumelin, Christoph E., Ferguson, Andrew, Fiez-Vandal, Cédric, Geschwindner, Stefan, Guié, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Schlenker, Oliver, Sigel, Eric A., Snijder, Arjan, Soutter, Holly T., Sundström, Linda, Troast, Dawn M., Wiggin, Giselle, Zhang, Jing, Zhang, Ying, Clark, Matthew A.
Published in SLAS discovery (01.06.2018)
Published in SLAS discovery (01.06.2018)
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Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling
Channavajhala, Padma L., Wu, Leeying, Cuozzo, John W., Hall, J. Perry, Liu, Wei, Lin, Lih-Ling, Zhang, Yuhua
Published in The Journal of biological chemistry (21.11.2003)
Published in The Journal of biological chemistry (21.11.2003)
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Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library
Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.
Published in Chembiochem : a European journal of chemical biology (04.05.2017)
Published in Chembiochem : a European journal of chemical biology (04.05.2017)
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Discovery of Nanomolar DCAF1 Small Molecule Ligands
Li, Alice Shi Ming, Kimani, Serah, Wilson, Brian, Noureldin, Mahmoud, González-Álvarez, Héctor, Mamai, Ahmed, Hoffer, Laurent, Guilinger, John P., Zhang, Ying, von Rechenberg, Moritz, Disch, Jeremy S., Mulhern, Christopher J., Slakman, Belinda L., Cuozzo, John W., Dong, Aiping, Poda, Gennady, Mohammed, Mohammed, Saraon, Punit, Mittal, Manish, Modh, Pratik, Rathod, Vaibhavi, Patel, Bhashant, Ackloo, Suzanne, Santhakumar, Vijayaratnam, Szewczyk, Magdalena M, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Marcellus, Richard, Guié, Marie-Aude, Keefe, Anthony D., Brown, Peter J., Halabelian, Levon, Al-awar, Rima, Vedadi, Masoud
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening
Disch, Jeremy S, Duffy, Jennifer M, Lee, Esther C. Y, Gikunju, Diana, Chan, Betty, Levin, Benjamin, Monteiro, Michael I, Talcott, Sarah A, Lau, Anthony C, Zhou, Fei, Kozhushnyan, Anton, Westlund, Neil E, Mullins, Patrick B, Yu, Yan, von Rechenberg, Moritz, Zhang, Junyi, Arnautova, Yelena A, Liu, Yanbin, Zhang, Ying, McRiner, Andrew J, Keefe, Anthony D, Kohlmann, Anna, Clark, Matthew A, Cuozzo, John W, Huguet, Christelle, Arora, Shilpi
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Design, synthesis and selection of DNA-encoded small-molecule libraries
Morgan, Barry A, Clark, Matthew A, Acharya, Raksha A, Arico-Muendel, Christopher C, Belyanskaya, Svetlana L, Benjamin, Dennis R, Carlson, Neil R, Centrella, Paolo A, Chiu, Cynthia H, Creaser, Steffen P, Cuozzo, John W, Davie, Christopher P, Ding, Yun, Franklin, G Joseph, Franzen, Kurt D, Gefter, Malcolm L, Hale, Steven P, Hansen, Nils J V, Israel, David I, Jiang, Jinwei, Kavarana, Malcolm J, Kelley, Michael S, Kollmann, Christopher S, Li, Fan, Lind, Kenneth, Mataruse, Sibongile, Medeiros, Patricia F, Messer, Jeffrey A, Myers, Paul, O'Keefe, Heather, Oliff, Matthew C, Rise, Cecil E, Satz, Alexander L, Skinner, Steven R, Svendsen, Jennifer L, Tang, Lujia, van Vloten, Kurt, Wagner, Richard W, Yao, Gang, Zhao, Baoguang
Published in Nature Chemical Biology (01.09.2009)
Published in Nature Chemical Biology (01.09.2009)
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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning
Ahmad, Shabbir, Xu, Jin, Feng, Jianwen A., Hutchinson, Ashley, Zeng, Hong, Ghiabi, Pegah, Dong, Aiping, Centrella, Paolo A., Clark, Matthew A., Guié, Marie-Aude, Guilinger, John P., Keefe, Anthony D., Zhang, Ying, Cerruti, Thomas, Cuozzo, John W., von Rechenberg, Moritz, Bolotokova, Albina, Li, Yanjun, Loppnau, Peter, Seitova, Alma, Li, Yen-Yen, Santhakumar, Vijayaratnam, Brown, Peter J., Ackloo, Suzanne, Halabelian, Levon
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry
Guilinger, John P., Archna, Archna, Augustin, Martin, Bergmann, Andreas, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Däther, Maike, Guié, Marie-Aude, Habeshian, Sevan, Kiefersauer, Reiner, Krapp, Stephan, Lammens, Alfred, Lercher, Lukas, Liu, Julie, Liu, Yanbin, Maskos, Klaus, Mrosek, Michael, Pflügler, Klaus, Siegert, Markus, Thomson, Heather A., Tian, Xia, Zhang, Ying, Konz Makino, Debora L., Keefe, Anthony D.
Published in Bioorganic & medicinal chemistry (15.07.2021)
Published in Bioorganic & medicinal chemistry (15.07.2021)
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Development of Potent Mcl‑1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen
Hekking, Koen F. W., Maroto, Sergio, van Kekem, Kees, Haasjes, Frank S., Slootweg, Jack C., Oude Alink, Patrick G. B., Dirks, Ron, Sardana, Malvika, Bolster, Marjon G., Kuijpers, Brian, Smith, Dennis, Doodeman, Robin, Scheepstra, Marcel, Zech, Birgit, Mulvihill, Mark, Renzetti, Louis M., Babiss, Lee, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Guié, Marie-Aude, Sigel, Eric, Habeshian, Sevan, Hupp, Christopher D., Liu, Julie, Thomson, Heather A., Zhang, Ying, Keefe, Anthony D., Müller, Gerhard, Gremmen, Stijn
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa
Ryan, M. Dominic, Parkes, Alastair L, Corbett, David, Dickie, Anthony P, Southey, Michelle, Andersen, Ole A, Stein, Daniel B, Barbeau, Olivier R, Sanzone, Angelo, Thommes, Pia, Barker, John, Cain, Ricky, Compper, Christel, Dejob, Magali, Dorali, Alain, Etheridge, Donnya, Evans, Sian, Faulkner, Adele, Gadouleau, Elise, Gorman, Timothy, Haase, Denes, Holbrow-Wilshaw, Maisie, Krulle, Thomas, Li, Xianfu, Lumley, Christopher, Mertins, Barbara, Napier, Spencer, Odedra, Rajesh, Papadopoulos, Kostas, Roumpelakis, Vasileios, Spear, Kate, Trimby, Emily, Williams, Jennifer, Zahn, Michael, Keefe, Anthony D, Zhang, Ying, Soutter, Holly T, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Deng, Boer, Hunt, Avery, Sigel, Eric A, Troast, Dawn M, DeJonge, Boudewijn L. M
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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